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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SMAD2

Summary for SMAD2

Gene information	Gene symbol	SMAD2
	Ensembl ID	ENSG00000175387
	Entrez ID	4087
	Gene name	SMAD family member 2
	Synonyms	JV18-1\|MADH2\|MADR2
	Gene type	protein_coding
	UniProtAcc	Q15796

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Dataset with differentially expressed gene: SMAD2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.337248	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.312453	8.30e-43
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.47283	0.00e+00

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Expression of SMAD2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SMAD2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SMAD2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SMAD2	hsa-miR-5011-5p	99.9945	NM_001003652
SMAD2	hsa-miR-190a-3p	99.9469	NM_001003652
SMAD2	hsa-miR-656-3p	99.7016	NM_001003652
SMAD2	hsa-miR-1264	99.2506	NM_001003652
SMAD2	hsa-miR-7159-5p	98.9859	NM_001003652
SMAD2	hsa-miR-4719	98.814	NM_001003652
SMAD2	hsa-miR-3613-3p	97.9599	NM_001003652
SMAD2	hsa-miR-340-5p	97.3781	NM_001003652
SMAD2	hsa-miR-95-5p	97.0879	NM_001003652
SMAD2	hsa-miR-551b-5p	97.0706	NM_001003652
SMAD2	hsa-miR-3148	96.803	NM_001003652
SMAD2	hsa-miR-8485	96.6391	NM_001003652
SMAD2	hsa-miR-4422	96.5601	NM_001003652
SMAD2	hsa-miR-624-3p	95.7595	NM_001003652
SMAD2	hsa-miR-4496	95.471	NM_001003652
SMAD2	hsa-miR-3714	95.1415	NM_001003652
SMAD2	hsa-miR-4272	94.2067	NM_001003652
SMAD2	hsa-miR-6868-3p	93.6888	NM_001003652
SMAD2	hsa-miR-4799-5p	93.5129	NM_001003652
SMAD2	hsa-miR-3913-5p	92.8633	NM_001003652
SMAD2	hsa-miR-223-5p	92.3482	NM_001003652
SMAD2	hsa-miR-155-5p	91.9563	NM_001003652
SMAD2	hsa-miR-3122	91.7175	NM_001003652
SMAD2	hsa-miR-5590-3p	91.1427	NM_001003652
SMAD2	hsa-miR-142-5p	91.1427	NM_001003652
SMAD2	hsa-miR-590-3p	91.1228	NM_001003652
SMAD2	hsa-miR-3121-3p	91.0954	NM_001003652
SMAD2	hsa-miR-3184-3p	91.0487	NM_001003652
SMAD2	hsa-miR-5002-5p	90.4721	NM_001003652
SMAD2	hsa-miR-607	90.1664	NM_001003652
SMAD2	hsa-miR-498-3p	90.1204	NM_001003652
SMAD2	hsa-miR-5692a	89.0646	NM_001003652
SMAD2	hsa-miR-5004-5p	89.005	NM_001003652
SMAD2	hsa-miR-12124	88.9881	NM_001003652
SMAD2	hsa-miR-520d-5p	88.8649	NM_001003652
SMAD2	hsa-miR-524-5p	88.8649	NM_001003652
SMAD2	hsa-miR-6511a-5p	88.7763	NM_001003652
SMAD2	hsa-miR-1910-3p	88.6692	NM_001003652
SMAD2	hsa-miR-6878-5p	88.2029	NM_001003652
SMAD2	hsa-miR-3679-3p	87.6654	NM_001003652
SMAD2	hsa-miR-1237-3p	87.6511	NM_001003652
SMAD2	hsa-miR-6134	87.2715	NM_001003652
SMAD2	hsa-miR-302a-5p	86.9761	NM_001003652
SMAD2	hsa-miR-520e-5p	86.949	NM_001003652
SMAD2	hsa-miR-4761-5p	86.8242	NM_001003652
SMAD2	hsa-miR-374a-5p	86.672	NM_001003652
SMAD2	hsa-miR-1302	86.6539	NM_001003652
SMAD2	hsa-miR-208a-5p	85.8279	NM_001003652
SMAD2	hsa-miR-208b-5p	85.8279	NM_001003652
SMAD2	hsa-miR-374b-3p	85.7661	NM_001003652

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Motifs and transcription factors (TFs) regulating SMAD2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SMAD2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
SMAD2	transfac_pro__M07436	WT1 (directAnnotation).
SMAD2	transfac_pro__M02281	SP1 (directAnnotation).
SMAD2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
SMAD2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SMAD2	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
SMAD2	transfac_pro__M02898	SMAD3 (directAnnotation).
SMAD2	transfac_public__M00491	PATZ1 (directAnnotation).
SMAD2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
SMAD2	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
SMAD2	metacluster_135.11	NR2C2 (directAnnotation).
SMAD2	tfdimers__MD00038	TFAP2C (directAnnotation).
SMAD2	cisbp__M00968	MTF2 (directAnnotation).
SMAD2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SMAD2	cisbp__M00341	PAX6 (directAnnotation).
SMAD2	metacluster_198.3	ZFP64 (directAnnotation).
SMAD2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SMAD2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SMAD2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SMAD2	cisbp__M00788	ZFY (inferredBy_Orthology).
SMAD2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SMAD2	metacluster_175.1	ZNF283 (directAnnotation).
SMAD2	hdpi__ZNF304	ZNF304 (directAnnotation).
SMAD2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SMAD2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SMAD2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SMAD2	transfac_pro__M01199	TRIM28 (directAnnotation).
SMAD2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SMAD2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SMAD2	transfac_pro__M03806	ZBTB7C (directAnnotation).
SMAD2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SMAD2	"Dexfosfoserine"	DB04522	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."