Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE140440 | DU145 and PCÂ cell lines | Cell line | Prostate cancer | Prostate cancer | Chemotherapy | docetaxel | NA | Malignant cells | 0.588906 | 1.46e-02 |
GSE169246_PacBlood | patients | Peripheral blood mononuclear cells | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | post | Plasma cells | -0.276832 | 6.50e-04 |
GSE169246_PacBlood | patients | Peripheral blood mononuclear cells | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | pDCs | 0.434554 | 4.52e-03 |
GSE169246_PacBlood | patients | Peripheral blood mononuclear cells | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | B cells | 0.318816 | 1.10e-42 |
GSE169246_PacBlood | patients | Peripheral blood mononuclear cells | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | CD4+ T cells | 0.404025 | 0.00e+00 |
GSE169246_PacBlood | patients | Peripheral blood mononuclear cells | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | NK cells | 0.311384 | 0.00e+00 |
GSE169246_PacBlood | patients | Peripheral blood mononuclear cells | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | cDCs | 0.3345 | 8.00e-06 |
GSE169246_PacTissue | patients | Tumor tissue | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | CD8+ T cells | 0.250165 | 7.15e-44 |
GSE169246_PacTissue | patients | Tumor tissue | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | CD4+ T cells | 0.289882 | 7.32e-36 |
GSE207422_Sin | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | B cells | 0.331217 | 2.34e-04 |
GSE189460 | patients | Bone marrow aspirate | Multiple myeloma | Multiple myeloma (MM) | Targeted therapy | bortezomib + melphalan + prednisolone | pre | Malignant cells | 0.463563 | 0.00e+00 |
GSE139386 | H3122 cell line | Cell line | Lung cancer | EML4-ALK fusion-positive non-small cell lung cancer (NSCLC) | Targeted therapy | ceritinib | NA | Malignant cells | 0.345104 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | Malignant cells | 0.288211 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | CD8+ T cells | -0.329481 | 4.08e-40 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | NK cells | -0.582659 | 0.00e+00 |
GSE104987 | MCF7 cell line | Cell line | Breast cancer | ER+ breast cancer | Targeted therapy | KDM5-C70 | NA | Malignant cells | 0.277304 | 2.14e-15 |
Gene symbol | motif | TF_highConf |
SLC38A1 | metacluster_135.10 | MBD2; MBD2; MECP2; MECP2 (directAnnotation). |
SLC38A1 | metacluster_126.3 | LIN28B; LIN28B (directAnnotation). |
SLC38A1 | metacluster_55.3 | E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology). |
SLC38A1 | dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1 | ZSCAN30 (directAnnotation). |
SLC38A1 | metacluster_141.5 | NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology). |
SLC38A1 | transfac_pro__M01199 | TRIM28 (directAnnotation). |
SLC38A1 | hdpi__ELF2 | ELF2 (directAnnotation). |
SLC38A1 | kznf__ZNF571_Imbeault2017_OM_RCADE | ZNF571 (directAnnotation). |
SLC38A1 | taipale_tf_pairs__ETS2_RCCGGAAGTG_HT | ETS2 (directAnnotation). |
SLC38A1 | jaspar__MA1483.2 | ELF2 (directAnnotation). |
SLC38A1 | transfac_pro__M04826 | EP300 (directAnnotation). |
SLC38A1 | metacluster_191.2 | ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology). |
SLC38A1 | metacluster_191.3 | EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology). |
SLC38A1 | swissregulon__hs__ELF2 | ELF2 (directAnnotation). |
SLC38A1 | metacluster_166.4 | BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology). |
SLC38A1 | hdpi__TP73 | TP73 (directAnnotation). |
SLC38A1 | cisbp__M08198 | ELF1 (directAnnotation). |
SLC38A1 | metacluster_55.5 | ZNF541 (directAnnotation). |
SLC38A1 | transfac_pro__M04950 | EGR1 (directAnnotation). |
SLC38A1 | transfac_pro__M06032 | ZNF727 (directAnnotation). |
SLC38A1 | metacluster_141.2 | E2F2; E2F3 (directAnnotation). |
SLC38A1 | cisbp__M02645 | ETS1 (directAnnotation). |
SLC38A1 | taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP | ETV1; TEAD4 (directAnnotation). |
SLC38A1 | hocomoco__TYY2_HUMAN.H11MO.0.D | YY2 (directAnnotation). |
SLC38A1 | transfac_pro__M06687 | ZNF334 (directAnnotation). |
SLC38A1 | flyfactorsurvey__Sug_F3-5-2_SOLEXA_5 | GLIS2 (inferredBy_Orthology). |
SLC38A1 | taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNGGCGCSN_CAP_repr | E2F3; TBX21 (directAnnotation). |
SLC38A1 | transfac_pro__M06267 | ZNF805 (directAnnotation). |
SLC38A1 | metacluster_141.9 | TAF1; YY1; YY1 (directAnnotation). |
SLC38A1 | hdpi__EBF1 | EBF1 (directAnnotation). |
SLC38A1 | metacluster_183.4 | ETS1 (inferredBy_Orthology). |
SLC38A1 | hdpi__NRL | NRL (directAnnotation). |
SLC38A1 | flyfactorsurvey__Mad_FlyReg_FBgn0011648 | SMAD9 (inferredBy_Orthology). |
SLC38A1 | cisbp__M00341 | PAX6 (directAnnotation). |
SLC38A1 | cisbp__M00968 | MTF2 (directAnnotation). |
SLC38A1 | hdpi__FEZF2 | FEZF2 (directAnnotation). |
SLC38A1 | transfac_pro__M07310 | SP5 (directAnnotation). |
SLC38A1 | metacluster_67.2 | ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology). |
SLC38A1 | metacluster_61.1 | DEAF1; DEAF1 (directAnnotation). |
SLC38A1 | swissregulon__hs__ZBTB14 | ZBTB14 (directAnnotation). |
SLC38A1 | kznf__ZNF548_Imbeault2017_RP_RCADE | ZNF548 (directAnnotation). |
SLC38A1 | hdpi__HTATIP2 | HTATIP2 (directAnnotation). |
SLC38A1 | transfac_pro__M01240 | GTF2IRD1 (directAnnotation). |
SLC38A1 | idmmpmm__Mad | SMAD9 (inferredBy_Orthology). |
SLC38A1 | transfac_pro__M02089 | E2F3 (directAnnotation). |
SLC38A1 | cisbp__M07938 | E2F1 (directAnnotation). |
SLC38A1 | transfac_pro__M02933 | ZBTB14 (inferredBy_Orthology). |
SLC38A1 | transfac_pro__M04817 | ZBTB33 (directAnnotation). |
SLC38A1 | taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP | ETV5; HES7 (directAnnotation). |
SLC38A1 | tfdimers__MD00483 | ZBTB14 (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |