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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SLC25A4

Summary for SLC25A4

Gene information	Gene symbol	SLC25A4
	Ensembl ID	ENSG00000151729
	Entrez ID	291
	Gene name	solute carrier family 25 member 4
	Synonyms	AAC1\|ANT1\|PEO2\|PEO3\|T1
	Gene type	protein_coding
	UniProtAcc	P12235

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Dataset with differentially expressed gene: SLC25A4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.83993	6.97e-06
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.350491	3.55e-12
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.665052	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.617185	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.259223	9.33e-09
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.370128	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.26512	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.522847	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.375286	0.00e+00

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Expression of SLC25A4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC25A4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLC25A4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC25A4	hsa-miR-95-5p	93.9815	NM_001151
SLC25A4	hsa-miR-3126-3p	92.9795	NM_001151
SLC25A4	hsa-miR-4662a-3p	92.8885	NM_001151
SLC25A4	hsa-miR-497-3p	91.3697	NM_001151
SLC25A4	hsa-miR-7110-5p	90.0111	NM_001151
SLC25A4	hsa-miR-6842-5p	90.0111	NM_001151
SLC25A4	hsa-miR-586	88.6082	NM_001151
SLC25A4	hsa-miR-7162-3p	86.9082	NM_001151
SLC25A4	hsa-miR-6752-5p	86.8191	NM_001151
SLC25A4	hsa-miR-302a-5p	84.5089	NM_001151
SLC25A4	hsa-miR-4799-3p	84.3	NM_001151
SLC25A4	hsa-miR-5588-5p	84.3	NM_001151
SLC25A4	hsa-miR-4720-5p	84.3	NM_001151
SLC25A4	hsa-miR-4291	83.5598	NM_001151
SLC25A4	hsa-miR-1912-5p	82.8606	NM_001151
SLC25A4	hsa-miR-556-3p	81.9681	NM_001151
SLC25A4	hsa-let-7c-3p	80.4575	NM_001151
SLC25A4	hsa-miR-582-5p	80.2279	NM_001151

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Motifs and transcription factors (TFs) regulating SLC25A4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC25A4	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SLC25A4	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SLC25A4	cisbp__M00788	ZFY (inferredBy_Orthology).
SLC25A4	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SLC25A4	metacluster_175.1	ZNF283 (directAnnotation).
SLC25A4	hdpi__ZNF304	ZNF304 (directAnnotation).
SLC25A4	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SLC25A4	transfac_pro__M01199	TRIM28 (directAnnotation).
SLC25A4	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SLC25A4	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SLC25A4	transfac_pro__M03806	ZBTB7C (directAnnotation).
SLC25A4	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SLC25A4	metacluster_165.3	HOMEZ; HOMEZ; HOMEZ (directAnnotation).
SLC25A4	hocomoco__KAISO_HUMAN.H11MO.2.A	ZBTB33 (directAnnotation).
SLC25A4	transfac_pro__M06181	ZNF165 (directAnnotation).
SLC25A4	metacluster_141.2	E2F2; E2F3 (directAnnotation).
SLC25A4	transfac_pro__M04748	GABPA (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SLC25A4	"ATP"	DB00171	small molecule
SLC25A4	"Carboxyatractyloside"	DB02426	small molecule
SLC25A4	"Clodronic acid"	DB00720	small molecule
SLC25A4	"Di-Stearoyl-3-Sn-Phosphatidylcholine"	DB04178	small molecule
SLC25A4	"Etidronic acid"	DB01077	small molecule
SLC25A4	"Tetrastearoyl cardiolipin"	DB03429	small molecule
SLC25A4	"[3-(Dodecanoylamino)Propyl](Hydroxy)Dimethylammonium"	DB01736	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."