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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SIK3

Summary for SIK3

Gene information	Gene symbol	SIK3
	Ensembl ID	ENSG00000160584
	Entrez ID	23387
	Gene name	SIK family kinase 3
	Synonyms	FLJ12240\|KIAA0999\|L19\|QSK
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SIK3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.274687	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.281223	0.00e+00

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Expression of SIK3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SIK3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SIK3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SIK3	hsa-miR-5011-5p	100	NM_025164
SIK3	hsa-miR-190a-3p	100	NM_001281748
SIK3	hsa-miR-656-3p	99.9984	NM_025164
SIK3	hsa-miR-5692c	99.889	NM_025164
SIK3	hsa-miR-5692b	99.889	NM_025164
SIK3	hsa-miR-1277-5p	99.8547	NM_025164
SIK3	hsa-miR-4753-3p	97.9593	NM_025164
SIK3	hsa-miR-4773	96.2514	NM_001281748
SIK3	hsa-miR-564	95.8476	NM_001281748
SIK3	hsa-miR-4262	95.4134	NM_001281748
SIK3	hsa-miR-6809-3p	95.1436	NM_025164
SIK3	hsa-miR-181c-5p	94.5815	NM_001281748
SIK3	hsa-miR-181d-5p	94.5815	NM_001281748
SIK3	hsa-miR-181b-5p	94.5815	NM_001281748
SIK3	hsa-miR-181a-5p	94.5815	NM_001281748
SIK3	hsa-miR-330-3p	92.4049	NM_001281748
SIK3	hsa-miR-500a-5p	90.9161	NM_025164
SIK3	hsa-miR-29b-2-5p	90.8692	NM_001281748
SIK3	hsa-miR-1252-3p	90.7361	NM_025164
SIK3	hsa-miR-6069	88.1998	NM_001281748
SIK3	hsa-miR-130a-5p	87.2872	NM_025164
SIK3	hsa-miR-4709-3p	86.7743	NM_025164
SIK3	hsa-miR-3144-5p	84.4218	NM_001281748
SIK3	hsa-miR-4718	82.6774	NM_001281748
SIK3	hsa-miR-4318	81.4048	NM_001281748
SIK3	hsa-miR-539-5p	81.3479	NM_025164
SIK3	hsa-miR-6077	81.1973	NM_025164
SIK3	hsa-miR-3908	81.0291	NM_001281748
SIK3	hsa-miR-96-5p	80.2469	NM_001281748

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Motifs and transcription factors (TFs) regulating SIK3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SIK3	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
SIK3	metacluster_143.13	ZBTB7A (directAnnotation).
SIK3	tfdimers__MD00552	USF2; ZBTB14 (directAnnotation).
SIK3	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
SIK3	transfac_pro__M07387	ZBTB7A (directAnnotation).
SIK3	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
SIK3	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
SIK3	metacluster_144.13	HIC1; HIC1 (directAnnotation).
SIK3	transfac_pro__M00514	ATF4 (directAnnotation).
SIK3	transfac_pro__M00665	SP3 (directAnnotation).
SIK3	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SIK3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SIK3	transfac_pro__M02898	SMAD3 (directAnnotation).
SIK3	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
SIK3	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
SIK3	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SIK3	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
SIK3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SIK3	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
SIK3	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
SIK3	transfac_pro__M07329	SP7 (directAnnotation).
SIK3	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
SIK3	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SIK3	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
SIK3	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
SIK3	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
SIK3	transfac_pro__M01861	ATF1 (directAnnotation).
SIK3	taipale_cyt_meth__JUND_NRTGACGCATN_eDBD_repr	JUND (directAnnotation).
SIK3	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
SIK3	transfac_pro__M00801	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM (directAnnotation). ATF7-NPFF (inferredBy_Orthology).
SIK3	metacluster_111.4	ATF1; ATF1; ATF1; ATF1; ATF1; ATF1; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF5; ATF6; ATF6B; ATF7; ATF7; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB3; CREB3L4; CREB3L4; CREB5; CREB5; CREB5; CREM; CREM; CREM; CREM; CREM; FOSB; FOSL1; FOSL1; FOSL2; JDP2; JDP2; JDP2; JUN; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; XBP1; XBP1; XBP1; ZNF629 (directAnnotation). ATF1; ATF1; ATF1; ATF2; ATF2; ATF3; ATF6; ATF6B; ATF7; ATF7; ATF7; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; BATF; BATF2; BATF3; CREB1; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREM; FOS; FOSB; FOSL1; FOSL2; JDP2; JDP2 (inferredBy_Orthology).
SIK3	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
SIK3	metacluster_111.5	E4F1; E4F1 (directAnnotation).
SIK3	metacluster_148.1	ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6; ATF6B; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB3; CREB3; CREB5; CREB5; CREB5; CREM; CREM; FOS; FOS; FOSB; FOSB; FOSB; FOSL1; JDP2; JDP2; JUN; JUN; JUN; JUNB; JUND; MAF; MAF; MAFA; MAFA; MAFF; MAFF; MAFF; MAFF; MAFG; MAFG; ZBTB21 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM; JDP2; JUN; JUNB; JUND; MAFB (inferredBy_Orthology).
SIK3	hdpi__NRL	NRL (directAnnotation).
SIK3	transfac_pro__M08803	CREM (directAnnotation).
SIK3	hdpi__PDLIM5	PDLIM5 (directAnnotation).
SIK3	transfac_public__M00039	CREB1 (directAnnotation).
SIK3	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
SIK3	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
SIK3	hdpi__OTUD4	OTUD4 (directAnnotation).
SIK3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SIK3	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SIK3	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."