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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SIAH2

Summary for SIAH2

Gene information	Gene symbol	SIAH2
	Ensembl ID	ENSG00000181788
	Entrez ID	6478
	Gene name	siah E3 ubiquitin protein ligase 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	O43255

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Dataset with differentially expressed gene: SIAH2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.334237	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.492052	3.67e-19
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.367985	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	1.03823	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.250199	2.11e-07
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.468882	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.277077	1.50e-20

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Expression of SIAH2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SIAH2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
SIAH2	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating SIAH2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SIAH2	hsa-miR-548aj-3p	94.3185	NM_005067
SIAH2	hsa-miR-548x-3p	94.3185	NM_005067
SIAH2	hsa-miR-7153-5p	92.7605	NM_005067
SIAH2	hsa-miR-146a-5p	92.7605	NM_005067
SIAH2	hsa-miR-146b-5p	92.7605	NM_005067
SIAH2	hsa-miR-548aq-3p	92.5795	NM_005067
SIAH2	hsa-miR-548ah-3p	92.5795	NM_005067
SIAH2	hsa-miR-548am-3p	92.5795	NM_005067
SIAH2	hsa-miR-548ae-3p	92.5795	NM_005067
SIAH2	hsa-miR-548j-3p	92.5795	NM_005067
SIAH2	hsa-miR-548bb-3p	92.1463	NM_005067
SIAH2	hsa-miR-548h-3p	92.1463	NM_005067
SIAH2	hsa-miR-548d-3p	92.1463	NM_005067
SIAH2	hsa-miR-548z	92.1463	NM_005067
SIAH2	hsa-miR-548ac	92.1463	NM_005067
SIAH2	hsa-miR-6835-3p	90.8086	NM_005067
SIAH2	hsa-miR-188-3p	90.1402	NM_005067
SIAH2	hsa-miR-451b	90.1279	NM_005067
SIAH2	hsa-miR-3617-5p	89.0212	NM_005067
SIAH2	hsa-miR-641	89.0212	NM_005067
SIAH2	hsa-miR-671-5p	86.989	NM_005067
SIAH2	hsa-miR-1275	84.6677	NM_005067
SIAH2	hsa-miR-6764-5p	81.4711	NM_005067
SIAH2	hsa-miR-371a-5p	80.4032	NM_005067

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Motifs and transcription factors (TFs) regulating SIAH2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SIAH2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
SIAH2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
SIAH2	transfac_pro__M00716	ZBTB14 (directAnnotation).
SIAH2	transfac_pro__M07310	SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."