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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SH3GLB1

Summary for SH3GLB1

Gene information	Gene symbol	SH3GLB1
	Ensembl ID	ENSG00000097033
	Entrez ID	51100
	Gene name	SH3 domain containing GRB2 like, endophilin B1
	Synonyms	Bif-1\|CGI-61\|KIAA0491\|PPP1R70
	Gene type	protein_coding
	UniProtAcc	Q9Y371

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Dataset with differentially expressed gene: SH3GLB1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.11481	6.37e-13
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.28289	1.70e-19
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.255472	5.02e-25
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.359578	2.80e-45
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.376354	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.425031	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.275074	0.00e+00

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Expression of SH3GLB1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SH3GLB1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SH3GLB1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SH3GLB1	hsa-miR-3143	98.1928	NM_001206651
SH3GLB1	hsa-miR-891a-3p	97.2456	NM_001206651
SH3GLB1	hsa-miR-4762-3p	95.8006	NM_016009
SH3GLB1	hsa-miR-570-3p	95.462	NM_001206651
SH3GLB1	hsa-miR-513c-3p	94.3925	NM_016009
SH3GLB1	hsa-miR-513a-3p	94.3925	NM_016009
SH3GLB1	hsa-miR-936	94.3735	NM_001206651
SH3GLB1	hsa-miR-4803	94.2993	NM_016009
SH3GLB1	hsa-miR-3919	94.1739	NM_016009
SH3GLB1	hsa-miR-5682	94.1452	NM_001206651
SH3GLB1	hsa-miR-222-5p	93.9968	NM_016009
SH3GLB1	hsa-miR-2467-5p	93.9577	NM_016009
SH3GLB1	hsa-miR-3686	91.8342	NM_016009
SH3GLB1	hsa-miR-4677-5p	91.2214	NM_016009
SH3GLB1	hsa-miR-3606-3p	91.1128	NM_016009
SH3GLB1	hsa-miR-767-5p	91.0616	NM_001206651
SH3GLB1	hsa-miR-548ao-5p	90.419	NM_016009
SH3GLB1	hsa-miR-548ax	90.419	NM_016009
SH3GLB1	hsa-miR-30e-3p	90.2459	NM_016009
SH3GLB1	hsa-miR-30d-3p	90.2459	NM_016009
SH3GLB1	hsa-miR-30a-3p	90.2459	NM_016009
SH3GLB1	hsa-miR-4424	90.0543	NM_016009
SH3GLB1	hsa-miR-29a-5p	89.9984	NM_001206651
SH3GLB1	hsa-miR-4311	89.799	NM_016009
SH3GLB1	hsa-miR-4778-5p	89.0989	NM_016009
SH3GLB1	hsa-miR-590-3p	88.6567	NM_001206651
SH3GLB1	hsa-miR-2116-5p	87.846	NM_016009
SH3GLB1	hsa-miR-95-5p	87.822	NM_001206651
SH3GLB1	hsa-miR-12136	87.6066	NM_001206651
SH3GLB1	hsa-miR-548aj-3p	86.7407	NM_016009
SH3GLB1	hsa-miR-548x-3p	86.7407	NM_016009
SH3GLB1	hsa-miR-29c-3p	86.6886	NM_001206651
SH3GLB1	hsa-miR-29a-3p	86.6886	NM_001206651
SH3GLB1	hsa-miR-29b-3p	86.6886	NM_001206651
SH3GLB1	hsa-miR-199a-3p	86.4737	NM_016009
SH3GLB1	hsa-miR-199b-3p	86.4737	NM_016009
SH3GLB1	hsa-miR-3129-5p	86.4737	NM_016009
SH3GLB1	hsa-miR-5681b	86.0692	NM_016009
SH3GLB1	hsa-miR-3606-5p	85.9769	NM_001206651
SH3GLB1	hsa-miR-335-3p	84.922	NM_016009
SH3GLB1	hsa-miR-4261	84.7843	NM_016009
SH3GLB1	hsa-miR-548ao-3p	84.7014	NM_016009
SH3GLB1	hsa-miR-7-5p	84.3299	NM_016009
SH3GLB1	hsa-miR-302c-5p	84.2853	NM_001206651
SH3GLB1	hsa-miR-374a-3p	84.2738	NM_016009
SH3GLB1	hsa-miR-3688-5p	84.2738	NM_001206651
SH3GLB1	hsa-miR-548am-3p	84.2248	NM_016009
SH3GLB1	hsa-miR-548aq-3p	84.2248	NM_016009
SH3GLB1	hsa-miR-548j-3p	84.2248	NM_016009
SH3GLB1	hsa-miR-548ah-3p	84.2248	NM_016009

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Motifs and transcription factors (TFs) regulating SH3GLB1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SH3GLB1	transfac_pro__M02898	SMAD3 (directAnnotation).
SH3GLB1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SH3GLB1	metacluster_191.5	SPDEF (inferredBy_Orthology).
SH3GLB1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
SH3GLB1	hdpi__TIMELESS	TIMELESS (directAnnotation).
SH3GLB1	cisbp__M00249	WT1 (directAnnotation).
SH3GLB1	transfac_pro__M00430	E2F1 (directAnnotation).
SH3GLB1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
SH3GLB1	hdpi__ZNF304	ZNF304 (directAnnotation).
SH3GLB1	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
SH3GLB1	transfac_pro__M00938	E2F1 (directAnnotation).
SH3GLB1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
SH3GLB1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
SH3GLB1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SH3GLB1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
SH3GLB1	jaspar__MA1721.1	ZNF93 (directAnnotation).
SH3GLB1	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
SH3GLB1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
SH3GLB1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
SH3GLB1	transfac_pro__M01199	TRIM28 (directAnnotation).
SH3GLB1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
SH3GLB1	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
SH3GLB1	transfac_pro__M01253	CNOT3 (directAnnotation).
SH3GLB1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
SH3GLB1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
SH3GLB1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
SH3GLB1	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
SH3GLB1	cisbp__M00968	MTF2 (directAnnotation).
SH3GLB1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SH3GLB1	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
SH3GLB1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
SH3GLB1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
SH3GLB1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
SH3GLB1	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
SH3GLB1	transfac_pro__M07310	SP5 (directAnnotation).
SH3GLB1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
SH3GLB1	transfac_pro__M04817	ZBTB33 (directAnnotation).
SH3GLB1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
SH3GLB1	transfac_pro__M12697	ZNF142 (directAnnotation).
SH3GLB1	metacluster_175.1	ZNF283 (directAnnotation).
SH3GLB1	tfdimers__MD00364	WT1 (directAnnotation).
SH3GLB1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
SH3GLB1	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
SH3GLB1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
SH3GLB1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SH3GLB1	transfac_pro__M04916	TAF1 (directAnnotation).
SH3GLB1	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
SH3GLB1	transfac_pro__M01973	PLAG1 (directAnnotation).
SH3GLB1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
SH3GLB1	tfdimers__MD00483	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."