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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SH3BP5

Summary for SH3BP5

Gene information	Gene symbol	SH3BP5
	Ensembl ID	ENSG00000131370
	Entrez ID	9467
	Gene name	SH3 domain binding protein 5
	Synonyms	Sab
	Gene type	protein_coding
	UniProtAcc	O60239

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Dataset with differentially expressed gene: SH3BP5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.31747	1.51e-06
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.303896	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.31538	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.320084	1.39e-17
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.460071	1.91e-02
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	B cells	0.306034	2.81e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.340532	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.580377	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.276595	2.20e-28
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	Malignant cells	-0.377967	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.832022	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.277409	0.00e+00

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Expression of SH3BP5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SH3BP5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SH3BP5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SH3BP5	hsa-miR-12133	99.2991	NM_001018009
SH3BP5	hsa-miR-1271-5p	99.2557	NM_001018009
SH3BP5	hsa-miR-96-5p	99.2367	NM_001018009
SH3BP5	hsa-miR-3692-3p	94.8723	NM_001018009
SH3BP5	hsa-miR-3944-5p	94.3642	NM_001018009
SH3BP5	hsa-miR-4660	93.6241	NM_001018009
SH3BP5	hsa-miR-4709-3p	92.2904	NM_001018009
SH3BP5	hsa-miR-568	92.1389	NM_001018009
SH3BP5	hsa-miR-7977	91.0654	NM_004844
SH3BP5	hsa-miR-12122	90.5711	NM_001018009
SH3BP5	hsa-miR-3688-3p	89.8936	NM_004844
SH3BP5	hsa-miR-580-5p	89.5303	NM_004844
SH3BP5	hsa-miR-4642	89.3058	NM_001018009
SH3BP5	hsa-miR-2115-5p	87.7507	NM_001018009
SH3BP5	hsa-miR-182-5p	87.1216	NM_001018009
SH3BP5	hsa-miR-6508-5p	86.3442	NM_004844
SH3BP5	hsa-miR-6863	85.4788	NM_004844
SH3BP5	hsa-miR-2278	84.7715	NM_001018009
SH3BP5	hsa-miR-10399-5p	84.7009	NM_001018009
SH3BP5	hsa-miR-6504-3p	84.7009	NM_001018009
SH3BP5	hsa-miR-20a-5p	83.9604	NM_001018009
SH3BP5	hsa-miR-106b-5p	83.9604	NM_001018009
SH3BP5	hsa-miR-3127-3p	83.5053	NM_004844
SH3BP5	hsa-miR-519d-3p	83.3357	NM_001018009
SH3BP5	hsa-miR-93-5p	83.3357	NM_001018009
SH3BP5	hsa-miR-106a-5p	83.3357	NM_001018009
SH3BP5	hsa-miR-526b-3p	83.3357	NM_001018009
SH3BP5	hsa-miR-20b-5p	83.3357	NM_001018009
SH3BP5	hsa-miR-17-5p	83.3357	NM_001018009
SH3BP5	hsa-miR-4796-3p	83.3301	NM_004844
SH3BP5	hsa-miR-8067	82.6074	NM_004844
SH3BP5	hsa-miR-5680	82.5041	NM_001018009
SH3BP5	hsa-miR-5692a	82.3399	NM_004844
SH3BP5	hsa-miR-6756-3p	80.9719	NM_004844
SH3BP5	hsa-miR-5696	80.176	NM_004844

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Motifs and transcription factors (TFs) regulating SH3BP5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SH3BP5	transfac_pro__M04948	HNF4G (directAnnotation).
SH3BP5	hdpi__MAGED4	MAGED4 (directAnnotation).
SH3BP5	metacluster_117.2	GATA3; GATA3; GATA3; GATA5; GATA5; GATA5; GATA5; GATA6; GATA6 (directAnnotation).
SH3BP5	transfac_pro__M03803	SOX17 (directAnnotation).
SH3BP5	transfac_pro__M06642	ZSCAN10 (directAnnotation).
SH3BP5	transfac_pro__M06671	ZNF285 (directAnnotation).
SH3BP5	taipale_tf_pairs__MYBL1_TBX21_AGGTGTGNCSGTTR_CAP_repr	MYBL1; TBX21 (directAnnotation).
SH3BP5	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
SH3BP5	transfac_pro__M06282	ZSCAN10 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."