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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SFXN1

Summary for SFXN1

Gene information	Gene symbol	SFXN1
	Ensembl ID	ENSG00000164466
	Entrez ID	94081
	Gene name	sideroflexin 1
	Synonyms	FLJ12876\|SLC56A1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SFXN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	0.315893	1.36e-02
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.508911	1.04e-39
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.295279	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.498455	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.335846	4.76e-40
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.26172	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.292455	6.09e-15
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.369921	1.25e-14
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.327872	4.10e-14
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.405596	0.00e+00

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Expression of SFXN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SFXN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SFXN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SFXN1	hsa-miR-429	93.6494	NM_001322981
SFXN1	hsa-miR-1297	93.4693	NM_001322981
SFXN1	hsa-miR-6866-3p	93.3543	NM_001322981
SFXN1	hsa-miR-188-5p	93.2212	NM_001322981
SFXN1	hsa-miR-200c-3p	92.6073	NM_001322981
SFXN1	hsa-miR-200b-3p	92.6073	NM_001322981
SFXN1	hsa-miR-3689b-5p	92.4006	NM_001322983
SFXN1	hsa-miR-3689f	92.4006	NM_001322983
SFXN1	hsa-miR-3689e	92.4006	NM_001322983
SFXN1	hsa-miR-3689a-5p	92.4006	NM_001322983
SFXN1	hsa-miR-548e-5p	92.2198	NM_001322981
SFXN1	hsa-miR-26b-5p	91.7708	NM_001322981
SFXN1	hsa-miR-26a-5p	91.7708	NM_001322981
SFXN1	hsa-miR-4465	89.7167	NM_001322981
SFXN1	hsa-miR-215-3p	89.138	NM_001322982
SFXN1	hsa-miR-203b-3p	88.9451	NM_001322982
SFXN1	hsa-miR-340-5p	88.6816	NM_001322982
SFXN1	hsa-miR-558	88.3358	NM_001322982
SFXN1	hsa-miR-3613-3p	87.64	NM_001322982
SFXN1	hsa-miR-4325	87.5281	NM_001322981
SFXN1	hsa-miR-3919	85.227	NM_001322982
SFXN1	hsa-miR-646	84.7294	NM_001322981
SFXN1	hsa-miR-6505-5p	84.6095	NM_001322983
SFXN1	hsa-miR-5680	84.5659	NM_001322981
SFXN1	hsa-miR-335-3p	84.3475	NM_001322982
SFXN1	hsa-miR-4427	83.1358	NM_001322981
SFXN1	hsa-miR-92a-3p	82.898	NM_001322981
SFXN1	hsa-miR-32-5p	82.898	NM_001322981
SFXN1	hsa-miR-92b-3p	82.898	NM_001322981
SFXN1	hsa-miR-96-3p	81.7463	NM_001322982
SFXN1	hsa-miR-4495	81.6153	NM_001322981
SFXN1	hsa-miR-938	81.5731	NM_001322982
SFXN1	hsa-miR-4680-3p	81.5007	NM_001322981
SFXN1	hsa-miR-4677-5p	81.3147	NM_001322981
SFXN1	hsa-miR-4682	80.7795	NM_001322982
SFXN1	hsa-miR-6088	80.6904	NM_001322982
SFXN1	hsa-miR-143-3p	80.5275	NM_001322982
SFXN1	hsa-miR-4770	80.5275	NM_001322982
SFXN1	hsa-miR-6832-3p	80.4756	NM_001322982

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Motifs and transcription factors (TFs) regulating SFXN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SFXN1	transfac_pro__M00938	E2F1 (directAnnotation).
SFXN1	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
SFXN1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
SFXN1	cisbp__M00968	MTF2 (directAnnotation).
SFXN1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SFXN1	hdpi__HTATIP2	HTATIP2 (directAnnotation).
SFXN1	jaspar__MA1721.1	ZNF93 (directAnnotation).
SFXN1	transfac_pro__M04916	TAF1 (directAnnotation).
SFXN1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SFXN1	transfac_pro__M07310	SP5 (directAnnotation).
SFXN1	hdpi__ZNF304	ZNF304 (directAnnotation).
SFXN1	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
SFXN1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
SFXN1	metacluster_141.4	GLIS2 (directAnnotation).
SFXN1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
SFXN1	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
SFXN1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
SFXN1	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
SFXN1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
SFXN1	swissregulon__hs__ELF2	ELF2 (directAnnotation).
SFXN1	cisbp__M02645	ETS1 (directAnnotation).
SFXN1	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
SFXN1	jaspar__MA1708.1	ETV7 (directAnnotation).
SFXN1	metacluster_183.4	ETS1 (inferredBy_Orthology).
SFXN1	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
SFXN1	swissregulon__hs__ETV6	ETV6 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."