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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SERBP1

Summary for SERBP1

Gene information	Gene symbol	SERBP1
	Ensembl ID	ENSG00000142864
	Entrez ID	26135
	Gene name	SERPINE1 mRNA binding protein 1
	Synonyms	CGI-55\|CHD3IP\|DKFZP564M2423\|HABP4L\|PAI-RBP1\|PAIRBP1
	Gene type	protein_coding
	UniProtAcc	Q8NC51

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Dataset with differentially expressed gene: SERBP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.336017	4.24e-39
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.252283	2.40e-39
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.265585	7.03e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.250556	2.85e-03
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.573438	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	0.286694	1.07e-02
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.608281	1.03e-20
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.369135	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.382688	5.81e-10
GSE161195	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	DARA-KRD (daratumumab + carfilzomib + lenalidomide + dexamethasone)	post	Malignant cells	0.303662	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.334427	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.55744	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.514286	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.260238	1.84e-21
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.302343	5.07e-04
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.14038	1.55e-06
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.301204	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.431284	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.274592	7.83e-17
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.695541	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.464939	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.383065	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	1.04856	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-1.10817	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-1.19282	0.00e+00

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Expression of SERBP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SERBP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SERBP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SERBP1	hsa-miR-5093	99.67	NM_001018067
SERBP1	hsa-miR-8485	99.2829	NM_001018067
SERBP1	hsa-miR-548ap-3p	97.5028	NM_001018067
SERBP1	hsa-miR-548t-3p	97.5028	NM_001018067
SERBP1	hsa-miR-548aa	97.5028	NM_001018067
SERBP1	hsa-miR-3163	97.0292	NM_001018067
SERBP1	hsa-miR-4799-5p	95.8635	NM_001018069
SERBP1	hsa-miR-548c-3p	95.4299	NM_001018069
SERBP1	hsa-miR-4282	94.9038	NM_001018067
SERBP1	hsa-miR-7151-5p	94.6627	NM_001018069
SERBP1	hsa-miR-4790-3p	94.6409	NM_001018067
SERBP1	hsa-miR-3682-5p	94.4094	NM_001018069
SERBP1	hsa-miR-1228-3p	93.2815	NM_001018069
SERBP1	hsa-miR-3613-3p	92.4897	NM_001018069
SERBP1	hsa-miR-1297	91.0431	NM_001018067
SERBP1	hsa-miR-548d-3p	90.0392	NM_001018069
SERBP1	hsa-miR-548ac	89.4449	NM_001018069
SERBP1	hsa-miR-548bb-3p	89.4449	NM_001018069
SERBP1	hsa-miR-548h-3p	89.4449	NM_001018069
SERBP1	hsa-miR-548z	89.4449	NM_001018069
SERBP1	hsa-miR-6838-5p	88.862	NM_001018067
SERBP1	hsa-miR-15a-5p	88.862	NM_001018067
SERBP1	hsa-miR-497-5p	88.862	NM_001018067
SERBP1	hsa-miR-16-5p	88.862	NM_001018067
SERBP1	hsa-miR-195-5p	88.862	NM_001018067
SERBP1	hsa-miR-15b-5p	88.862	NM_001018067
SERBP1	hsa-miR-424-5p	88.862	NM_001018067
SERBP1	hsa-miR-26b-5p	86.9019	NM_001018067
SERBP1	hsa-miR-26a-5p	86.9019	NM_001018067
SERBP1	hsa-miR-4695-5p	86.852	NM_001018067
SERBP1	hsa-miR-5011-5p	86.1691	NM_001018069
SERBP1	hsa-miR-548bc	86.1235	NM_001018067
SERBP1	hsa-miR-548f-3p	86.1235	NM_001018067
SERBP1	hsa-miR-548a-3p	86.0891	NM_001018067
SERBP1	hsa-miR-548n	86.0781	NM_001018067
SERBP1	hsa-miR-500a-5p	85.4734	NM_001018069
SERBP1	hsa-miR-548aj-5p	85.0519	NM_001018067
SERBP1	hsa-miR-548g-5p	85.0519	NM_001018067
SERBP1	hsa-miR-548f-5p	85.0519	NM_001018067
SERBP1	hsa-miR-548x-5p	85.0519	NM_001018067
SERBP1	hsa-miR-454-3p	84.7629	NM_001018069
SERBP1	hsa-miR-548az-3p	84.1326	NM_001018067
SERBP1	hsa-miR-12124	84.0872	NM_001018067
SERBP1	hsa-miR-5682	83.9206	NM_001018067
SERBP1	hsa-miR-12136	83.8757	NM_001018067
SERBP1	hsa-miR-12120	83.8435	NM_001018067
SERBP1	hsa-miR-1257	83.8194	NM_001018067
SERBP1	hsa-miR-548ar-3p	83.6935	NM_001018067
SERBP1	hsa-miR-146a-3p	83.6842	NM_001018069
SERBP1	hsa-miR-4308	82.9952	NM_001018069

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Motifs and transcription factors (TFs) regulating SERBP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SERBP1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
SERBP1	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
SERBP1	metacluster_141.9	TAF1; YY1; YY1 (directAnnotation).
SERBP1	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
SERBP1	metacluster_144.10	ZNF100 (directAnnotation).
SERBP1	transfac_pro__M04918	EGR1 (directAnnotation).
SERBP1	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
SERBP1	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
SERBP1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
SERBP1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
SERBP1	cisbp__M00788	ZFY (inferredBy_Orthology).
SERBP1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
SERBP1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SERBP1	hdpi__ELF2	ELF2 (directAnnotation).
SERBP1	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
SERBP1	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
SERBP1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
SERBP1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
SERBP1	cisbp__M08198	ELF1 (directAnnotation).
SERBP1	homer__NCCACGTG_c-Myc	MYC (directAnnotation).
SERBP1	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
SERBP1	transfac_pro__M06032	ZNF727 (directAnnotation).
SERBP1	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
SERBP1	taipale_tf_pairs__ERF_TBX21_TMACACCGGAAG_CAP	ERF; TBX21 (directAnnotation).
SERBP1	metacluster_141.2	E2F2; E2F3 (directAnnotation).
SERBP1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
SERBP1	transfac_pro__M00492	STAT1 (directAnnotation).
SERBP1	metacluster_141.4	GLIS2 (directAnnotation).
SERBP1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
SERBP1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SERBP1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
SERBP1	swissregulon__hs__GLIS2	GLIS2 (directAnnotation).
SERBP1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
SERBP1	transfac_pro__M01253	CNOT3 (directAnnotation).
SERBP1	jaspar__MA1122.1	TFDP1 (directAnnotation).
SERBP1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
SERBP1	cisbp__M00968	MTF2 (directAnnotation).
SERBP1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SERBP1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SERBP1	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
SERBP1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
SERBP1	swissregulon__hs__ELF2	ELF2 (directAnnotation).
SERBP1	swissregulon__hs__ELK1	ELK1 (directAnnotation).
SERBP1	metacluster_183.4	ETS1 (inferredBy_Orthology).
SERBP1	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
SERBP1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SERBP1	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
SERBP1	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
SERBP1	hocomoco__KAISO_HUMAN.H11MO.2.A	ZBTB33 (directAnnotation).
SERBP1	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."