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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SENP6

Summary for SENP6

Gene information	Gene symbol	SENP6
	Ensembl ID	ENSG00000112701
	Entrez ID	26054
	Gene name	SUMO specific peptidase 6
	Synonyms	KIAA0797\|SUSP1
	Gene type	protein_coding
	UniProtAcc	Q9GZR1

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Dataset with differentially expressed gene: SENP6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.282706	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.276566	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.262975	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.279883	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.26565	8.08e-14

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Expression of SENP6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SENP6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SENP6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SENP6	hsa-miR-5692a	99.445	NM_001100409
SENP6	hsa-miR-664b-3p	97.3273	NM_001100409
SENP6	hsa-miR-579-3p	97.3273	NM_001100409
SENP6	hsa-miR-153-5p	94.8602	NM_001100409
SENP6	hsa-miR-5010-3p	94.7733	NM_001100409
SENP6	hsa-miR-4276	93.9305	NM_001100409
SENP6	hsa-miR-6719-3p	93.6464	NM_001100409
SENP6	hsa-miR-6878-3p	93.5059	NM_001100409
SENP6	hsa-miR-3682-3p	92.1582	NM_001100409
SENP6	hsa-miR-7-1-3p	90.8976	NM_001100409
SENP6	hsa-miR-7-2-3p	90.8976	NM_001100409
SENP6	hsa-miR-1275	90.7855	NM_001100409
SENP6	hsa-miR-4665-5p	90.7855	NM_001100409
SENP6	hsa-miR-186-5p	90.4807	NM_001100409
SENP6	hsa-miR-4672	89.7858	NM_001100409
SENP6	hsa-miR-4773	89.3689	NM_001100409
SENP6	hsa-miR-3059-5p	89.0632	NM_001100409
SENP6	hsa-miR-425-5p	88.9482	NM_001100409
SENP6	hsa-miR-4691-5p	88.7461	NM_001100409
SENP6	hsa-miR-6792-3p	88.7461	NM_001100409
SENP6	hsa-miR-6749-3p	88.7461	NM_001100409
SENP6	hsa-miR-5688	87.7453	NM_001100409
SENP6	hsa-miR-5680	87.5161	NM_001100409
SENP6	hsa-miR-556-3p	87.0889	NM_001100409
SENP6	hsa-miR-137-3p	86.922	NM_001100409
SENP6	hsa-miR-495-3p	86.2043	NM_001100409
SENP6	hsa-miR-655-3p	85.8235	NM_001100409
SENP6	hsa-miR-374c-5p	85.8235	NM_001100409
SENP6	hsa-miR-548aa	85.3506	NM_001100409
SENP6	hsa-miR-548ap-3p	85.3506	NM_001100409
SENP6	hsa-miR-548t-3p	85.3506	NM_001100409
SENP6	hsa-miR-4277	84.9388	NM_001100409
SENP6	hsa-miR-8067	84.1736	NM_001304792
SENP6	hsa-miR-6508-5p	84.1736	NM_001304792
SENP6	hsa-miR-337-3p	84.1723	NM_001100409
SENP6	hsa-miR-340-5p	83.6723	NM_001100409
SENP6	hsa-miR-190a-3p	83.3969	NM_001100409
SENP6	hsa-miR-4328	83.305	NM_001100409
SENP6	hsa-miR-23a-3p	82.6478	NM_001100409
SENP6	hsa-miR-23c	82.6478	NM_001100409
SENP6	hsa-miR-23b-3p	82.6478	NM_001100409
SENP6	hsa-miR-1266-3p	82.2237	NM_001100409
SENP6	hsa-miR-625-5p	82.0559	NM_001100409
SENP6	hsa-miR-4744	82.0099	NM_001100409
SENP6	hsa-miR-5696	81.982	NM_001100409
SENP6	hsa-miR-670-3p	81.4776	NM_001100409
SENP6	hsa-miR-4729	80.9187	NM_001100409
SENP6	hsa-miR-335-3p	80.259	NM_001100409

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Motifs and transcription factors (TFs) regulating SENP6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SENP6	transfac_pro__M12697	ZNF142 (directAnnotation).
SENP6	transfac_pro__M00716	ZBTB14 (directAnnotation).
SENP6	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
SENP6	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
SENP6	transfac_pro__M04893	TAF1 (directAnnotation).
SENP6	transfac_pro__M01253	CNOT3 (directAnnotation).
SENP6	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
SENP6	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
SENP6	transfac_pro__M04916	TAF1 (directAnnotation).
SENP6	hdpi__RARA	RARA (directAnnotation).
SENP6	jaspar__MA1650.1	ZBTB14 (directAnnotation).
SENP6	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SENP6	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
SENP6	cisbp__M08228	PAX5 (directAnnotation).
SENP6	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
SENP6	transfac_pro__M00938	E2F1 (directAnnotation).
SENP6	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
SENP6	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
SENP6	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SENP6	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
SENP6	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
SENP6	metacluster_24.3	DIDO1; HINFP; ILF3; ZBTB21; ZFX; ZFX; ZNF283; ZNF37A; ZNF501; ZNF614 (directAnnotation). ZFY; ZFY (inferredBy_Orthology).
SENP6	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SENP6	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
SENP6	transfac_pro__M03846	SMAD5 (directAnnotation).
SENP6	metacluster_45.4	E2F2 (directAnnotation).
SENP6	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
SENP6	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
SENP6	cisbp__M00343	PAX6 (directAnnotation).
SENP6	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
SENP6	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
SENP6	transfac_pro__M12694	ZFP14 (directAnnotation).
SENP6	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
SENP6	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
SENP6	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
SENP6	swissregulon__hs__CHD1	CHD1 (directAnnotation).
SENP6	swissregulon__hs__KLF6	KLF6 (directAnnotation).
SENP6	transfac_pro__M02898	SMAD3 (directAnnotation).
SENP6	transfac_pro__M07387	ZBTB7A (directAnnotation).
SENP6	kznf__ZNF2_Imbeault2017_RP_ChIP-seq	ZNF2 (directAnnotation).
SENP6	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
SENP6	hdpi__TIMELESS	TIMELESS (directAnnotation).
SENP6	transfac_pro__M09837	ZNF449 (directAnnotation).
SENP6	transfac_pro__M00430	E2F1 (directAnnotation).
SENP6	kznf__ZNF311_Imbeault2017_RP_ChIP-seq	ZNF311 (directAnnotation).
SENP6	tfdimers__MD00364	WT1 (directAnnotation).
SENP6	hdpi__GTF3C2	GTF3C2 (directAnnotation).
SENP6	jaspar__MA1721.1	ZNF93 (directAnnotation).
SENP6	transfac_pro__M08005	TCFL5 (inferredBy_Orthology).
SENP6	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."