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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SELPLG

Summary for SELPLG

Gene information	Gene symbol	SELPLG
	Ensembl ID	ENSG00000110876
	Entrez ID	6404
	Gene name	selectin P ligand
	Synonyms	CD162\|PSGL-1
	Gene type	protein_coding
	UniProtAcc	Q14242

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Dataset with differentially expressed gene: SELPLG

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.310897	7.57e-44
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.29382	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.694536	2.26e-08
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.316347	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.389962	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD8+ T cells	0.276258	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.318317	3.48e-11
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	NK cells	-0.305652	1.84e-40
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD8+ T cells	0.266611	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.576571	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.365005	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.538371	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD4+ T cells	-0.339416	4.93e-06

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Expression of SELPLG in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SELPLG

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
SELPLG	CD4+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	CD4+ T cells	Mono/Macro	GSE111014	pre	sensitive
SELPLG	CD4+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	CD4+ T cells	NK cells	GSE111014	pre	sensitive
SELPLG	CD4+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	CD8+ T cells	CD4+ T cells	GSE111014	pre	sensitive
SELPLG	CD4+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	Mono/Macro	CD4+ T cells	GSE111014	pre	sensitive
SELPLG	CD4+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	NK cells	CD4+ T cells	GSE111014	pre	sensitive
SELPLG	CD4+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	CD4+ T cells	CD4+ T cells	GSE111014	pre	sensitive
SELPLG	CD4+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	CD4+ T cells	CD8+ T cells	GSE111014	pre	sensitive
SELPLG	CD4+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	CD4+ T cells	Malignant cells	GSE111014	pre	sensitive
SELPLG	NK cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	NK cells	B cells	GSE169246_PacBlood	post	resistant
SELPLG	NK cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	NK cells	CD4+ T cells	GSE169246_PacBlood	post	resistant
SELPLG	NK cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	NK cells	Mono/Macro	GSE169246_PacBlood	post	resistant
SELPLG	NK cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	NK cells	Progenitors	GSE169246_PacBlood	post	resistant
SELPLG	NK cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	NK cells	cDCs	GSE169246_PacBlood	post	resistant
SELPLG	NK cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	NK cells	pDCs	GSE169246_PacBlood	post	resistant
SELPLG	NK cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	pDCs	NK cells	GSE169246_PacBlood	post	resistant
SELPLG	CD8+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	CD8+ T cells	B cells	GSE169246_PacBlood	post	resistant
SELPLG	CD8+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	CD8+ T cells	CD4+ T cells	GSE169246_PacBlood	post	resistant
SELPLG	CD8+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	CD8+ T cells	Mono/Macro	GSE169246_PacBlood	post	resistant
SELPLG	CD8+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	CD8+ T cells	Progenitors	GSE169246_PacBlood	post	resistant
SELPLG	CD8+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	CD8+ T cells	pDCs	GSE169246_PacBlood	post	resistant
SELPLG	CD8+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	pDCs	CD8+ T cells	GSE169246_PacBlood	post	resistant
SELPLG	NK cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	NK cells	B cells	GSE169246_PacBlood	post	sensitive
SELPLG	NK cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	NK cells	CD4+ T cells	GSE169246_PacBlood	post	sensitive
SELPLG	NK cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	NK cells	Progenitors	GSE169246_PacBlood	post	sensitive
SELPLG	NK cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	NK cells	pDCs	GSE169246_PacBlood	post	sensitive
SELPLG	NK cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	pDCs	NK cells	GSE169246_PacBlood	post	sensitive
SELPLG	CD8+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	CD8+ T cells	B cells	GSE169246_PacBlood	post	sensitive
SELPLG	CD8+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	CD8+ T cells	CD4+ T cells	GSE169246_PacBlood	post	sensitive
SELPLG	CD8+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	CD8+ T cells	pDCs	GSE169246_PacBlood	post	sensitive
SELPLG	CD8+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	pDCs	CD8+ T cells	GSE169246_PacBlood	post	sensitive
SELPLG	CD8+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	CD8+ T cells	B cells	GSE169246_PacBlood	pre	resistant
SELPLG	CD8+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	CD8+ T cells	CD4+ T cells	GSE169246_PacBlood	pre	resistant
SELPLG	CD8+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	CD8+ T cells	Progenitors	GSE169246_PacBlood	pre	resistant
SELPLG	CD8+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	CD8+ T cells	pDCs	GSE169246_PacBlood	pre	resistant
SELPLG	CD8+ T cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	pDCs	CD8+ T cells	GSE169246_PacBlood	pre	resistant
SELPLG	NK cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	NK cells	B cells	GSE169246_PacBlood	pre	resistant
SELPLG	NK cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	NK cells	CD4+ T cells	GSE169246_PacBlood	pre	resistant
SELPLG	NK cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	NK cells	Progenitors	GSE169246_PacBlood	pre	resistant
SELPLG	NK cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	NK cells	pDCs	GSE169246_PacBlood	pre	resistant
SELPLG	NK cells	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	pDCs	NK cells	GSE169246_PacBlood	pre	resistant
SELPLG	pDCs	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	CD4+ T cells	pDCs	GSE169246_PacBlood	pre	resistant
SELPLG	pDCs	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	CD8+ T cells	pDCs	GSE169246_PacBlood	pre	resistant
SELPLG	pDCs	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	Mono/Macro	pDCs	GSE169246_PacBlood	pre	resistant
SELPLG	pDCs	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	NK cells	pDCs	GSE169246_PacBlood	pre	resistant
SELPLG	pDCs	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	Plasma cells	pDCs	GSE169246_PacBlood	pre	resistant
SELPLG	pDCs	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	cDCs	pDCs	GSE169246_PacBlood	pre	resistant
SELPLG	pDCs	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	pDCs	B cells	GSE169246_PacBlood	pre	resistant
SELPLG	pDCs	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	pDCs	CD4+ T cells	GSE169246_PacBlood	pre	resistant
SELPLG	pDCs	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	pDCs	CD8+ T cells	GSE169246_PacBlood	pre	resistant
SELPLG	pDCs	CPI-SS0D479FBB7	SELPLG_SELL	SELPLG	SELL	False	pDCs	Mono/Macro	GSE169246_PacBlood	pre	resistant

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SELPLG

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SELPLG	hsa-miR-6884-3p	83.2041	NM_001206609
SELPLG	hsa-miR-766-5p	82.5422	NM_001206609
SELPLG	hsa-miR-186-3p	82.3937	NM_001206609

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Motifs and transcription factors (TFs) regulating SELPLG

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SELPLG	jaspar__MA1955.1	FOXO1 (directAnnotation).
SELPLG	taipale_tf_pairs__FOXO1_ETV4_RWMAACAGGAARNN_CAP	ETV4; FOXO1 (directAnnotation).
SELPLG	jaspar__MA1946.1	FOXI1 (directAnnotation).
SELPLG	tfdimers__MD00221	FOXG1; FOXO1; GABPA (directAnnotation).
SELPLG	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SELPLG	"Neihulizumab"	DB16698	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."