Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SEL1L3

Summary for SEL1L3

Gene information	Gene symbol	SEL1L3
	Ensembl ID	ENSG00000091490
	Entrez ID	23231
	Gene name	SEL1L family member 3
	Synonyms	KIAA0746
	Gene type	protein_coding
	UniProtAcc	Q68CR1

Top

Dataset with differentially expressed gene: SEL1L3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.309827	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	-0.385423	3.11e-05
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	pDCs	0.680614	4.27e-02
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.305992	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.441497	2.18e-09
GSE161195	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	DARA-KRD (daratumumab + carfilzomib + lenalidomide + dexamethasone)	post	Malignant cells	-0.422204	0.00e+00
GSE161195	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	DARA-KRD (daratumumab + carfilzomib + lenalidomide + dexamethasone)	pre	Malignant cells	-0.436943	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.300655	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	B cells	0.955956	2.80e-02
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.382525	9.03e-28
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.670735	0.00e+00

Top

Expression of SEL1L3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to SEL1L3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating SEL1L3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SEL1L3	hsa-miR-8485	95.6195	NM_001297592
SEL1L3	hsa-miR-454-3p	95.1398	NM_001297592
SEL1L3	hsa-miR-4495	95.1366	NM_001297592
SEL1L3	hsa-miR-301b-3p	94.141	NM_001297592
SEL1L3	hsa-miR-301a-3p	94.141	NM_001297592
SEL1L3	hsa-miR-130b-3p	94.141	NM_001297592
SEL1L3	hsa-miR-3666	94.141	NM_001297592
SEL1L3	hsa-miR-4295	94.141	NM_001297592
SEL1L3	hsa-miR-130a-3p	94.141	NM_001297592
SEL1L3	hsa-miR-4524b-5p	93.9723	NM_001297592
SEL1L3	hsa-miR-4524a-5p	93.9723	NM_001297592
SEL1L3	hsa-miR-26a-2-3p	93.3564	NM_001297592
SEL1L3	hsa-miR-26a-1-3p	93.3564	NM_001297592
SEL1L3	hsa-miR-15a-5p	92.7506	NM_001297592
SEL1L3	hsa-miR-195-5p	92.7506	NM_001297592
SEL1L3	hsa-miR-16-5p	92.7506	NM_001297592
SEL1L3	hsa-miR-15b-5p	92.7506	NM_001297592
SEL1L3	hsa-miR-4699-3p	92.5985	NM_001297592
SEL1L3	hsa-miR-26b-3p	90.6011	NM_001297592
SEL1L3	hsa-miR-6757-5p	90.0981	NM_001297592
SEL1L3	hsa-miR-424-5p	89.8275	NM_001297592
SEL1L3	hsa-miR-6838-5p	89.8275	NM_001297592
SEL1L3	hsa-miR-497-5p	89.8275	NM_001297592
SEL1L3	hsa-miR-568	89.4991	NM_001297592
SEL1L3	hsa-miR-4775	87.8196	NM_001297592
SEL1L3	hsa-miR-4306	87.7508	NM_001297592
SEL1L3	hsa-miR-5692a	85.3831	NM_001297592
SEL1L3	hsa-miR-7110-3p	85.1679	NM_001297592
SEL1L3	hsa-miR-4644	83.9483	NM_001297592
SEL1L3	hsa-miR-185-5p	83.9483	NM_001297592
SEL1L3	hsa-miR-590-3p	80.7499	NM_001297592
SEL1L3	hsa-miR-518a-5p	80.1543	NM_001297592
SEL1L3	hsa-miR-527	80.1543	NM_001297592

Page: 1

Top

Motifs and transcription factors (TFs) regulating SEL1L3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SEL1L3	transfac_pro__M05521	ZNF398 (directAnnotation).
SEL1L3	tfdimers__MD00190	ARID3A; WT1 (directAnnotation).
SEL1L3	kznf__ZNF582_Imbeault2017_OM_MEME	ZNF582 (directAnnotation).
SEL1L3	transfac_pro__M05852	ZNF689 (directAnnotation).
SEL1L3	transfac_pro__M06907	ZFP3 (inferredBy_Orthology).
SEL1L3	hdpi__SSX3	SSX3 (directAnnotation).
SEL1L3	tfdimers__MD00052	GFI1; GFI1B; YY1 (directAnnotation).
SEL1L3	transfac_pro__M08187	ABL1 (directAnnotation).
SEL1L3	transfac_pro__M07310	SP5 (directAnnotation).
SEL1L3	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
SEL1L3	metacluster_155.11	SPZ1 (directAnnotation).
SEL1L3	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
SEL1L3	tfdimers__MD00066	ELF1 (directAnnotation).
SEL1L3	jaspar__MA1935.1	FOXI1 (directAnnotation).
SEL1L3	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
SEL1L3	homer__YCTTTGTTCC_Sox4	SOX4 (inferredBy_Orthology).
SEL1L3	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
SEL1L3	jaspar__MA1952.1	FOXJ2 (directAnnotation).
SEL1L3	transfac_pro__M12556	ETV4 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."