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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SEC63

Summary for SEC63

Gene information	Gene symbol	SEC63
	Ensembl ID	ENSG00000025796
	Entrez ID	11231
	Gene name	SEC63 homolog, protein translocation regulator
	Synonyms	DNAJC23\|ERdj2\|PRO2507\|SEC63L
	Gene type	protein_coding
	UniProtAcc	Q9UGP8

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Dataset with differentially expressed gene: SEC63

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.356024	1.74e-26
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	1.04559	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.340711	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.271202	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.458755	1.21e-38

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Expression of SEC63 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SEC63

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SEC63

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SEC63	hsa-miR-4687-5p	99.1389	NM_007214
SEC63	hsa-let-7c-3p	97.9769	NM_007214
SEC63	hsa-miR-33a-3p	97.6595	NM_007214
SEC63	hsa-miR-3613-3p	96.5469	NM_007214
SEC63	hsa-miR-338-5p	96.4985	NM_007214
SEC63	hsa-miR-129-1-3p	96.0553	NM_007214
SEC63	hsa-miR-6779-3p	96.0553	NM_007214
SEC63	hsa-miR-129-2-3p	96.0553	NM_007214
SEC63	hsa-miR-501-3p	95.829	NM_007214
SEC63	hsa-miR-502-3p	95.829	NM_007214
SEC63	hsa-miR-8485	95.5416	NM_007214
SEC63	hsa-miR-3121-3p	95.0822	NM_007214
SEC63	hsa-miR-4499	94.6448	NM_007214
SEC63	hsa-miR-3187-5p	94.5187	NM_007214
SEC63	hsa-miR-6860	94.5187	NM_007214
SEC63	hsa-miR-612	94.5187	NM_007214
SEC63	hsa-miR-548c-3p	94.2715	NM_007214
SEC63	hsa-miR-1285-3p	93.64	NM_007214
SEC63	hsa-miR-5189-5p	93.64	NM_007214
SEC63	hsa-miR-3651	92.6036	NM_007214
SEC63	hsa-miR-12135	92.25	NM_007214
SEC63	hsa-miR-186-5p	92.1846	NM_007214
SEC63	hsa-miR-12124	91.5682	NM_007214
SEC63	hsa-miR-656-3p	91.3766	NM_007214
SEC63	hsa-miR-373-5p	89.6644	NM_007214
SEC63	hsa-miR-371b-5p	89.6644	NM_007214
SEC63	hsa-miR-616-5p	89.6644	NM_007214
SEC63	hsa-miR-12127	88.9532	NM_007214
SEC63	hsa-miR-12129	88.3431	NM_007214
SEC63	hsa-miR-4638-3p	86.6916	NM_007214
SEC63	hsa-miR-3177-5p	86.3555	NM_007214
SEC63	hsa-miR-452-5p	86.0854	NM_007214
SEC63	hsa-miR-4676-3p	86.0854	NM_007214
SEC63	hsa-miR-892c-3p	86.0854	NM_007214
SEC63	hsa-miR-302a-5p	86.0217	NM_007214
SEC63	hsa-miR-1255a	85.9379	NM_007214
SEC63	hsa-miR-1255b-5p	85.9379	NM_007214
SEC63	hsa-miR-510-3p	85.2766	NM_007214
SEC63	hsa-miR-5692a	85.0709	NM_007214
SEC63	hsa-miR-3125	84.7112	NM_007214
SEC63	hsa-miR-5697	84.5974	NM_007214
SEC63	hsa-miR-3646	84.486	NM_007214
SEC63	hsa-miR-206	84.3722	NM_007214
SEC63	hsa-miR-1-3p	84.3722	NM_007214
SEC63	hsa-miR-493-5p	83.9592	NM_007214
SEC63	hsa-miR-6890-3p	83.4926	NM_007214
SEC63	hsa-miR-151a-3p	83.1112	NM_007214
SEC63	hsa-miR-4328	83.0757	NM_007214
SEC63	hsa-miR-6832-3p	83.0458	NM_007214
SEC63	hsa-miR-1289	82.8225	NM_007214

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Motifs and transcription factors (TFs) regulating SEC63

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SEC63	tfdimers__MD00151	CHURC1 (directAnnotation).
SEC63	tfdimers__MD00391	KLF4 (directAnnotation).
SEC63	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
SEC63	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SEC63	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
SEC63	cisbp__M00968	MTF2 (directAnnotation).
SEC63	transfac_pro__M01973	PLAG1 (directAnnotation).
SEC63	transfac_pro__M12697	ZNF142 (directAnnotation).
SEC63	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
SEC63	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SEC63	jaspar__MA0748.2	YY2 (directAnnotation).
SEC63	transfac_pro__M01303	SP1 (directAnnotation).
SEC63	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SEC63	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
SEC63	metacluster_3.14	WT1; WT1 (directAnnotation).
SEC63	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SEC63	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
SEC63	transfac_public__M00491	PATZ1 (directAnnotation).
SEC63	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SEC63	transfac_pro__M07397	ZNF148 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."