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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SCAF11

Summary for SCAF11

Gene information	Gene symbol	SCAF11
	Ensembl ID	ENSG00000139218
	Entrez ID	9169
	Gene name	SR-related CTD associated factor 11
	Synonyms	CASP11\|SFRS2IP\|SIP1\|SRRP129\|SRSF2IP
	Gene type	protein_coding
	UniProtAcc	Q99590

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Dataset with differentially expressed gene: SCAF11

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.285388	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.30113	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.276093	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.285206	5.95e-30
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.253949	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.20757	1.90e-10
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.399277	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.258594	3.35e-07
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.330723	0.00e+00

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Expression of SCAF11 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SCAF11

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SCAF11

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SCAF11	hsa-miR-576-5p	98.6459	NM_004719
SCAF11	hsa-miR-590-3p	98.1415	NM_004719
SCAF11	hsa-miR-5692a	97.3151	NM_004719
SCAF11	hsa-miR-1323	96.5958	NM_004719
SCAF11	hsa-miR-30d-3p	96.384	NM_004719
SCAF11	hsa-miR-30a-3p	96.384	NM_004719
SCAF11	hsa-miR-30e-3p	96.384	NM_004719
SCAF11	hsa-miR-548o-3p	95.8491	NM_004719
SCAF11	hsa-miR-4325	94.9713	NM_004719
SCAF11	hsa-miR-548aw	93.9433	NM_004719
SCAF11	hsa-miR-1825	93.3203	NM_004719
SCAF11	hsa-miR-7159-5p	93.0219	NM_004719
SCAF11	hsa-miR-6835-3p	92.3332	NM_004719
SCAF11	hsa-miR-4705	91.8058	NM_004719
SCAF11	hsa-miR-27a-3p	91.6043	NM_004719
SCAF11	hsa-miR-27b-3p	91.6043	NM_004719
SCAF11	hsa-miR-9985	91.6043	NM_004719
SCAF11	hsa-miR-1305	91.5051	NM_004719
SCAF11	hsa-miR-4482-3p	91.1418	NM_004719
SCAF11	hsa-miR-616-5p	91.0473	NM_004719
SCAF11	hsa-miR-371b-5p	91.0473	NM_004719
SCAF11	hsa-miR-373-5p	91.0473	NM_004719
SCAF11	hsa-miR-548g-5p	90.9729	NM_004719
SCAF11	hsa-miR-548x-5p	90.9729	NM_004719
SCAF11	hsa-miR-548f-5p	90.9729	NM_004719
SCAF11	hsa-miR-548aj-5p	90.9729	NM_004719
SCAF11	hsa-miR-5582-5p	90.6229	NM_004719
SCAF11	hsa-miR-1468-3p	90.4577	NM_004719
SCAF11	hsa-miR-12123	89.2037	NM_004719
SCAF11	hsa-miR-25-3p	88.5816	NM_004719
SCAF11	hsa-miR-92b-3p	88.5816	NM_004719
SCAF11	hsa-miR-92a-3p	88.5816	NM_004719
SCAF11	hsa-miR-363-3p	88.5816	NM_004719
SCAF11	hsa-miR-32-5p	88.5816	NM_004719
SCAF11	hsa-miR-367-3p	88.5816	NM_004719
SCAF11	hsa-miR-522-3p	88.5786	NM_004719
SCAF11	hsa-miR-224-3p	88.5786	NM_004719
SCAF11	hsa-miR-4766-5p	88.5381	NM_004719
SCAF11	hsa-miR-7159-3p	88.439	NM_004719
SCAF11	hsa-miR-655-3p	87.3156	NM_004719
SCAF11	hsa-miR-494-3p	86.7676	NM_004719
SCAF11	hsa-miR-676-5p	86.511	NM_004719
SCAF11	hsa-miR-4803	86.3475	NM_004719
SCAF11	hsa-miR-5002-5p	86.2742	NM_004719
SCAF11	hsa-miR-603	86.0136	NM_004719
SCAF11	hsa-miR-218-5p	85.7719	NM_004719
SCAF11	hsa-miR-374c-5p	85.5029	NM_004719
SCAF11	hsa-miR-374a-3p	85.0754	NM_004719
SCAF11	hsa-miR-892c-5p	84.8761	NM_004719
SCAF11	hsa-miR-206	84.433	NM_004719

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Motifs and transcription factors (TFs) regulating SCAF11

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SCAF11	jaspar__MA1721.1	ZNF93 (directAnnotation).
SCAF11	transfac_pro__M04916	TAF1 (directAnnotation).
SCAF11	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SCAF11	jaspar__MA1122.1	TFDP1 (directAnnotation).
SCAF11	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
SCAF11	transfac_pro__M07310	SP5 (directAnnotation).
SCAF11	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
SCAF11	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
SCAF11	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SCAF11	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
SCAF11	cisbp__M00249	WT1 (directAnnotation).
SCAF11	hdpi__ZNF304	ZNF304 (directAnnotation).
SCAF11	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
SCAF11	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
SCAF11	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
SCAF11	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
SCAF11	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
SCAF11	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
SCAF11	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
SCAF11	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
SCAF11	jaspar__MA1935.1	FOXI1 (directAnnotation).
SCAF11	metacluster_166.5	ERG; ETV2; FLI1 (directAnnotation).
SCAF11	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
SCAF11	swissregulon__hs__ETV6	ETV6 (directAnnotation).
SCAF11	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
SCAF11	jaspar__MA1708.1	ETV7 (directAnnotation).
SCAF11	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
SCAF11	metacluster_183.4	ETS1 (inferredBy_Orthology).
SCAF11	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
SCAF11	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SCAF11	transfac_pro__M01122	ZNF219 (directAnnotation).
SCAF11	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SCAF11	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
SCAF11	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
SCAF11	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
SCAF11	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
SCAF11	taipale_tf_pairs__GCM1_ERG_RTRYGGGCGGAARKN_CAP	ERG; GCM1 (directAnnotation).
SCAF11	metacluster_84.2	RARA (directAnnotation).
SCAF11	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
SCAF11	transfac_pro__M01253	CNOT3 (directAnnotation).
SCAF11	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
SCAF11	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
SCAF11	swissregulon__hs__CHD1	CHD1 (directAnnotation).
SCAF11	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
SCAF11	cisbp__M00341	PAX6 (directAnnotation).
SCAF11	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
SCAF11	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
SCAF11	tfdimers__MD00151	CHURC1 (directAnnotation).
SCAF11	tfdimers__MD00391	KLF4 (directAnnotation).
SCAF11	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."