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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: RUNX1

Summary for RUNX1

Gene information	Gene symbol	RUNX1
	Ensembl ID	ENSG00000159216
	Entrez ID	861
	Gene name	RUNX family transcription factor 1
	Synonyms	AML1\|AMLCR1\|CBFA2\|PEBP2A2
	Gene type	protein_coding
	UniProtAcc	Q01196

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Dataset with differentially expressed gene: RUNX1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.275254	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.379632	5.56e-30
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.990119	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.561842	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.283078	3.84e-17
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.594693	0.00e+00

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Expression of RUNX1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RUNX1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RUNX1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RUNX1	hsa-miR-548ah-5p	97.7105	NM_001001890
RUNX1	hsa-miR-3609	97.7105	NM_001001890
RUNX1	hsa-miR-12119	97.5416	NM_001122607
RUNX1	hsa-miR-190a-3p	97.2746	NM_001001890
RUNX1	hsa-miR-5011-5p	97.2128	NM_001001890
RUNX1	hsa-miR-3613-3p	97.1889	NM_001001890
RUNX1	hsa-miR-12136	97.1341	NM_001001890
RUNX1	hsa-miR-30b-5p	96.7497	NM_001001890
RUNX1	hsa-miR-30c-5p	96.7497	NM_001001890
RUNX1	hsa-miR-30d-5p	96.7497	NM_001001890
RUNX1	hsa-miR-30a-5p	96.7497	NM_001001890
RUNX1	hsa-miR-30e-5p	96.7497	NM_001001890
RUNX1	hsa-miR-27b-3p	96.7425	NM_001001890
RUNX1	hsa-miR-27a-3p	96.7425	NM_001001890
RUNX1	hsa-miR-9985	96.7425	NM_001001890
RUNX1	hsa-miR-5692a	96.5527	NM_001001890
RUNX1	hsa-miR-8485	96.5111	NM_001001890
RUNX1	hsa-miR-450b-5p	95.4131	NM_001001890
RUNX1	hsa-miR-9983-3p	94.4881	NM_001001890
RUNX1	hsa-miR-3163	94.4025	NM_001001890
RUNX1	hsa-miR-199b-3p	93.7888	NM_001001890
RUNX1	hsa-miR-3129-5p	93.7888	NM_001001890
RUNX1	hsa-miR-199a-3p	93.7888	NM_001001890
RUNX1	hsa-miR-129-5p	93.2526	NM_001001890
RUNX1	hsa-miR-4466	92.9676	NM_001001890
RUNX1	hsa-miR-675-5p	92.9676	NM_001001890
RUNX1	hsa-miR-548c-3p	92.7915	NM_001001890
RUNX1	hsa-miR-6507-3p	92.6068	NM_001001890
RUNX1	hsa-miR-144-3p	91.4672	NM_001001890
RUNX1	hsa-miR-3606-5p	91.4322	NM_001122607
RUNX1	hsa-miR-507	91.0365	NM_001001890
RUNX1	hsa-miR-6505-5p	90.5943	NM_001001890
RUNX1	hsa-miR-34a-3p	89.7182	NM_001001890
RUNX1	hsa-miR-18b-5p	89.0257	NM_001001890
RUNX1	hsa-miR-18a-5p	89.0257	NM_001001890
RUNX1	hsa-miR-557	88.1043	NM_001001890
RUNX1	hsa-miR-4735-3p	87.8099	NM_001001890
RUNX1	hsa-miR-3605-5p	87.6877	NM_001122607
RUNX1	hsa-miR-4646-3p	87.6019	NM_001122607
RUNX1	hsa-miR-1255a	86.988	NM_001122607
RUNX1	hsa-miR-1255b-5p	86.988	NM_001122607
RUNX1	hsa-miR-571	85.2514	NM_001001890
RUNX1	hsa-miR-222-5p	85.1163	NM_001001890
RUNX1	hsa-miR-513a-5p	84.2541	NM_001001890
RUNX1	hsa-miR-6834-3p	83.4263	NM_001001890
RUNX1	hsa-miR-30d-3p	82.4836	NM_001001890
RUNX1	hsa-miR-30a-3p	82.4836	NM_001001890
RUNX1	hsa-miR-30e-3p	82.4836	NM_001001890
RUNX1	hsa-miR-6850-5p	81.0831	NM_001001890
RUNX1	hsa-miR-5582-3p	81.0786	NM_001001890

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Motifs and transcription factors (TFs) regulating RUNX1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RUNX1	tfdimers__MD00269	CRX; PBX1 (directAnnotation).
RUNX1	metacluster_22.13	MAFK (inferredBy_Orthology).
RUNX1	metacluster_74.5	HNF1B (directAnnotation).
RUNX1	transfac_pro__M06181	ZNF165 (directAnnotation).
RUNX1	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
RUNX1	metacluster_22.32	NFE2L2 (directAnnotation).
RUNX1	metacluster_26.4	CDC5L; CDC5L; CDC5L; ZNF580; ZNF580 (directAnnotation).
RUNX1	transfac_pro__M06854	ZNF600 (directAnnotation).
RUNX1	tfdimers__MD00223	SOX9; TEAD1 (directAnnotation).
RUNX1	transfac_pro__M05898	ZSCAN4 (directAnnotation).
RUNX1	transfac_pro__M04948	HNF4G (directAnnotation).
RUNX1	metacluster_168.13	ZNF287; ZNF324; ZNF324B (directAnnotation). ZNF287 (inferredBy_Orthology).
RUNX1	cisbp__M00262	ARX (directAnnotation).
RUNX1	homer__TWGTCTGV_Smad3	SMAD3 (inferredBy_Orthology).
RUNX1	transfac_pro__M06131	ZNF10 (directAnnotation).
RUNX1	transfac_pro__M01665	IRF8 (directAnnotation).
RUNX1	transfac_pro__M01266	ELF1 (directAnnotation).
RUNX1	taipale_tf_pairs__GCM2_SOX15_ATRCGGGYNNNNNYWTTGTNN_CAP_repr	GCM2; SOX15 (directAnnotation).
RUNX1	metacluster_31.3	ZSCAN20; ZSCAN29 (directAnnotation).
RUNX1	metacluster_131.2	ZNF257 (directAnnotation).
RUNX1	hdpi__CBFB	CBFB (directAnnotation).
RUNX1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
RUNX1	hdpi__NRL	NRL (directAnnotation).
RUNX1	transfac_pro__M07310	SP5 (directAnnotation).
RUNX1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
RUNX1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
RUNX1	tfdimers__MD00483	ZBTB14 (directAnnotation).
RUNX1	transfac_pro__M02089	E2F3 (directAnnotation).
RUNX1	transfac_pro__M07317	CTBP1 (directAnnotation).
RUNX1	transfac_pro__M00716	ZBTB14 (directAnnotation).
RUNX1	transfac_pro__M03806	ZBTB7C (directAnnotation).
RUNX1	transfac_pro__M04893	TAF1 (directAnnotation).
RUNX1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
RUNX1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
RUNX1	jaspar__MA1650.1	ZBTB14 (directAnnotation).
RUNX1	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
RUNX1	hdpi__ZNF304	ZNF304 (directAnnotation).
RUNX1	cisbp__M08228	PAX5 (directAnnotation).
RUNX1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
RUNX1	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RUNX1	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
RUNX1	cisbp__M00788	ZFY (inferredBy_Orthology).
RUNX1	metacluster_24.3	DIDO1; HINFP; ILF3; ZBTB21; ZFX; ZFX; ZNF283; ZNF37A; ZNF501; ZNF614 (directAnnotation). ZFY; ZFY (inferredBy_Orthology).
RUNX1	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
RUNX1	transfac_pro__M03846	SMAD5 (directAnnotation).
RUNX1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RUNX1	metacluster_175.1	ZNF283 (directAnnotation).
RUNX1	cisbp__M00343	PAX6 (directAnnotation).
RUNX1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RUNX1	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
RUNX1	metacluster_8.3	up	Mono/Macro	GSE169246_PacAteTissue	pre

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."