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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RSF1

Summary for RSF1

Gene information	Gene symbol	RSF1
	Ensembl ID	ENSG00000048649
	Entrez ID	51773
	Gene name	remodeling and spacing factor 1
	Synonyms	HBXAP\|p325\|RSF-1\|XAP8
	Gene type	protein_coding
	UniProtAcc	Q96T23

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Dataset with differentially expressed gene: RSF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.336055	5.66e-15
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.287378	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	0.365772	8.99e-08
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.28852	9.66e-19
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.346927	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.579989	3.78e-44
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.259438	0.00e+00

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Expression of RSF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RSF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
RSF1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating RSF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RSF1	hsa-miR-374a-5p	96.5797	NM_016578
RSF1	hsa-miR-1277-5p	96.2435	NM_016578
RSF1	hsa-miR-5692b	96.1501	NM_016578
RSF1	hsa-miR-5692c	96.1501	NM_016578
RSF1	hsa-miR-374b-5p	94.9789	NM_016578
RSF1	hsa-miR-4659a-3p	94.3423	NM_016578
RSF1	hsa-miR-4659b-3p	94.3423	NM_016578
RSF1	hsa-miR-4517	93.0955	NM_016578
RSF1	hsa-miR-4762-5p	92.5236	NM_016578
RSF1	hsa-miR-3934-3p	92.5043	NM_016578
RSF1	hsa-miR-4659b-5p	92.4276	NM_016578
RSF1	hsa-miR-4659a-5p	92.4276	NM_016578
RSF1	hsa-miR-585-5p	92.2278	NM_016578
RSF1	hsa-miR-1245b-3p	91.1532	NM_016578
RSF1	hsa-miR-6773-5p	90.9779	NM_016578
RSF1	hsa-miR-6728-3p	90.2412	NM_016578
RSF1	hsa-miR-3148	89.715	NM_016578
RSF1	hsa-miR-3120-3p	89.6164	NM_016578
RSF1	hsa-miR-6724-5p	89.2459	NM_016578
RSF1	hsa-miR-5590-3p	89.0292	NM_016578
RSF1	hsa-miR-142-5p	89.0292	NM_016578
RSF1	hsa-miR-3942-3p	88.7299	NM_016578
RSF1	hsa-miR-653-5p	88.6742	NM_016578
RSF1	hsa-miR-5011-5p	87.9667	NM_016578
RSF1	hsa-miR-586	87.6799	NM_016578
RSF1	hsa-miR-194-5p	86.7714	NM_016578
RSF1	hsa-miR-20b-3p	86.5388	NM_016578
RSF1	hsa-let-7a-3p	86.1856	NM_016578
RSF1	hsa-let-7f-1-3p	86.1856	NM_016578
RSF1	hsa-let-7b-3p	86.1856	NM_016578
RSF1	hsa-miR-98-3p	86.1856	NM_016578
RSF1	hsa-miR-8087	85.7796	NM_016578
RSF1	hsa-miR-548u	85.2334	NM_016578
RSF1	hsa-miR-7161-5p	85.2334	NM_016578
RSF1	hsa-miR-5587-5p	84.9573	NM_016578
RSF1	hsa-miR-1272	84.7178	NM_016578
RSF1	hsa-miR-1322	84.7178	NM_016578
RSF1	hsa-miR-369-3p	83.4019	NM_016578
RSF1	hsa-miR-619-3p	82.5548	NM_016578
RSF1	hsa-miR-190a-3p	82.4245	NM_016578
RSF1	hsa-miR-4719	82.3614	NM_016578
RSF1	hsa-miR-4778-5p	82.2657	NM_016578
RSF1	hsa-miR-373-3p	81.8489	NM_016578
RSF1	hsa-miR-520a-3p	81.8489	NM_016578
RSF1	hsa-miR-520b-3p	81.8489	NM_016578
RSF1	hsa-miR-302c-3p	81.8489	NM_016578
RSF1	hsa-miR-302b-3p	81.8489	NM_016578
RSF1	hsa-miR-372-3p	81.8489	NM_016578
RSF1	hsa-miR-302e	81.8489	NM_016578
RSF1	hsa-miR-302a-3p	81.8489	NM_016578

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Motifs and transcription factors (TFs) regulating RSF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RSF1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RSF1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RSF1	cisbp__M00341	PAX6 (directAnnotation).
RSF1	metacluster_198.3	ZFP64 (directAnnotation).
RSF1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RSF1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RSF1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RSF1	cisbp__M00788	ZFY (inferredBy_Orthology).
RSF1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RSF1	hdpi__ZNF304	ZNF304 (directAnnotation).
RSF1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RSF1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RSF1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RSF1	transfac_pro__M01199	TRIM28 (directAnnotation).
RSF1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RSF1	metacluster_151.2	ZNF23 (directAnnotation).
RSF1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RSF1	transfac_pro__M03806	ZBTB7C (directAnnotation).
RSF1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RSF1	hdpi__TP73	TP73 (directAnnotation).
RSF1	cisbp__M02645	ETS1 (directAnnotation).
RSF1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RSF1	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
RSF1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
RSF1	jaspar__MA0748.2	YY2 (directAnnotation).
RSF1	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
RSF1	metacluster_182.10	ZFX (directAnnotation).
RSF1	transfac_pro__M00492	STAT1 (directAnnotation).
RSF1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
RSF1	cisbp__M00249	WT1 (directAnnotation).
RSF1	transfac_pro__M01122	ZNF219 (directAnnotation).
RSF1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
RSF1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
RSF1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
RSF1	swissregulon__hs__GLIS2	GLIS2 (directAnnotation).
RSF1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
RSF1	taipale_tf_pairs__GCM1_ERG_RTRYGGGCGGAARKN_CAP	ERG; GCM1 (directAnnotation).
RSF1	metacluster_84.2	RARA (directAnnotation).
RSF1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
RSF1	transfac_pro__M01253	CNOT3 (directAnnotation).
RSF1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
RSF1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RSF1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RSF1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
RSF1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWGNNNNNTCCGGNN_CAP	GCM1; SPDEF (directAnnotation).
RSF1	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
RSF1	tfdimers__MD00391	KLF4 (directAnnotation).
RSF1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
RSF1	tfdimers__MD00441	OVOL2; RELA (directAnnotation).
RSF1	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."