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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RNF24

Summary for RNF24

Gene information	Gene symbol	RNF24
	Ensembl ID	ENSG00000101236
	Entrez ID	11237
	Gene name	ring finger protein 24
	Synonyms	G1L
	Gene type	protein_coding
	UniProtAcc	Q9Y225

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Dataset with differentially expressed gene: RNF24

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.62422	1.12e-05
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.281779	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.363971	3.08e-36

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Expression of RNF24 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RNF24

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RNF24

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RNF24	hsa-miR-4728-5p	98.1627	NM_001134337
RNF24	hsa-miR-6785-5p	96.6028	NM_001134337
RNF24	hsa-miR-6883-5p	94.848	NM_001134337
RNF24	hsa-miR-149-3p	94.848	NM_001134337
RNF24	hsa-let-7a-3p	94.4006	NM_001134337
RNF24	hsa-let-7b-3p	94.4006	NM_001134337
RNF24	hsa-miR-98-3p	94.4006	NM_001134337
RNF24	hsa-let-7f-1-3p	94.4006	NM_001134337
RNF24	hsa-miR-6071	93.2532	NM_001321749
RNF24	hsa-miR-4766-3p	92.9521	NM_001134337
RNF24	hsa-miR-4703-5p	91.0518	NM_001321749
RNF24	hsa-miR-6508-5p	90.7851	NM_001134337
RNF24	hsa-miR-937-5p	90.558	NM_001321749
RNF24	hsa-miR-2467-5p	89.78	NM_001321749
RNF24	hsa-miR-660-3p	88.5063	NM_001321749
RNF24	hsa-miR-3613-3p	87.8302	NM_001134337
RNF24	hsa-miR-8067	87.4586	NM_001134337
RNF24	hsa-miR-548p	86.0689	NM_001134337
RNF24	hsa-miR-8081	85.0455	NM_001321749
RNF24	hsa-miR-4764-5p	84.9926	NM_001321749
RNF24	hsa-miR-4275	84.9373	NM_001134337
RNF24	hsa-miR-4441	84.3745	NM_001321749
RNF24	hsa-miR-3942-5p	84.0555	NM_001321749
RNF24	hsa-miR-3908	83.582	NM_001321749
RNF24	hsa-miR-1273h-5p	83.1211	NM_001134337
RNF24	hsa-miR-1285-3p	81.9556	NM_001321749
RNF24	hsa-miR-6513-5p	81.9037	NM_001321749
RNF24	hsa-miR-323b-5p	81.7281	NM_001321749
RNF24	hsa-miR-410-5p	81.7281	NM_001321749
RNF24	hsa-miR-494-5p	81.7281	NM_001321749
RNF24	hsa-miR-665	81.2904	NM_001321749
RNF24	hsa-miR-4282	81.2847	NM_001321749
RNF24	hsa-miR-3975	80.8779	NM_001321749
RNF24	hsa-miR-4251	80.6385	NM_001321749
RNF24	hsa-miR-6780a-5p	80.1446	NM_001134337

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Motifs and transcription factors (TFs) regulating RNF24

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RNF24	transfac_pro__M03876	ZBTB33 (directAnnotation).
RNF24	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RNF24	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
RNF24	metacluster_135.11	NR2C2 (directAnnotation).
RNF24	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RNF24	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RNF24	cisbp__M00968	MTF2 (directAnnotation).
RNF24	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RNF24	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RNF24	cisbp__M00341	PAX6 (directAnnotation).
RNF24	metacluster_198.3	ZFP64 (directAnnotation).
RNF24	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RNF24	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RNF24	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RNF24	cisbp__M00788	ZFY (inferredBy_Orthology).
RNF24	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RNF24	metacluster_175.1	ZNF283 (directAnnotation).
RNF24	hdpi__ZNF304	ZNF304 (directAnnotation).
RNF24	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RNF24	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RNF24	transfac_pro__M01199	TRIM28 (directAnnotation).
RNF24	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RNF24	metacluster_151.2	ZNF23 (directAnnotation).
RNF24	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RNF24	transfac_pro__M03806	ZBTB7C (directAnnotation).
RNF24	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."