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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RNF19A

Summary for RNF19A

Gene information	Gene symbol	RNF19A
	Ensembl ID	ENSG00000034677
	Entrez ID	25897
	Gene name	ring finger protein 19A, RBR E3 ubiquitin protein ligase
	Synonyms	DKFZp566B1346\|dorfin\|RNF19
	Gene type	protein_coding
	UniProtAcc	Q9NV58

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Dataset with differentially expressed gene: RNF19A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.28253	2.26e-19
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.280552	1.42e-30
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.260322	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.363314	4.34e-02
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.518463	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.296278	6.00e-17
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.342995	1.17e-14
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	NK cells	-0.285402	1.28e-02
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	-0.331239	5.76e-25
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD4+ T cells	-0.322688	7.84e-38
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.927073	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.876325	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.418163	1.81e-15
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.334807	4.96e-09
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.311288	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.342519	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.410372	5.35e-43
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.327536	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.254341	7.58e-18
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	0.434916	4.45e-05
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.765117	8.27e-44

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Expression of RNF19A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RNF19A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RNF19A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RNF19A	hsa-miR-20a-3p	99.0498	NM_001280539
RNF19A	hsa-miR-1184	98.7161	NM_001280539
RNF19A	hsa-miR-1253	96.0785	NM_001280539
RNF19A	hsa-miR-767-5p	95.2948	NM_001280539
RNF19A	hsa-miR-7152-5p	95.1779	NM_015435
RNF19A	hsa-miR-138-2-3p	95.0792	NM_015435
RNF19A	hsa-miR-8485	94.7579	NM_015435
RNF19A	hsa-miR-558	94.5702	NM_001280539
RNF19A	hsa-miR-95-5p	94.2678	NM_015435
RNF19A	hsa-miR-140-5p	93.6439	NM_001280539
RNF19A	hsa-miR-29c-3p	93.0413	NM_001280539
RNF19A	hsa-miR-29b-3p	93.0413	NM_001280539
RNF19A	hsa-miR-29a-3p	93.0413	NM_001280539
RNF19A	hsa-miR-4729	92.2064	NM_001280539
RNF19A	hsa-miR-655-5p	92.1568	NM_001280539
RNF19A	hsa-miR-5682	91.9259	NM_001280539
RNF19A	hsa-miR-200b-3p	91.4757	NM_001280539
RNF19A	hsa-miR-429	91.4757	NM_001280539
RNF19A	hsa-miR-200c-3p	91.4757	NM_001280539
RNF19A	hsa-miR-10527-5p	91.4677	NM_015435
RNF19A	hsa-miR-8084	91.303	NM_001280539
RNF19A	hsa-miR-9851-3p	91.2604	NM_001280539
RNF19A	hsa-miR-593-5p	91.2604	NM_001280539
RNF19A	hsa-miR-4460	90.5218	NM_001280539
RNF19A	hsa-miR-548f-5p	89.5731	NM_015435
RNF19A	hsa-miR-548aj-5p	89.5731	NM_015435
RNF19A	hsa-miR-548x-5p	89.5731	NM_015435
RNF19A	hsa-miR-548g-5p	89.5731	NM_015435
RNF19A	hsa-miR-7162-3p	89.454	NM_001280539
RNF19A	hsa-miR-133a-5p	89.2479	NM_001280539
RNF19A	hsa-miR-7157-5p	89.232	NM_015435
RNF19A	hsa-miR-548p	88.6888	NM_001280539
RNF19A	hsa-miR-7159-3p	88.4301	NM_015435
RNF19A	hsa-miR-3614-3p	88.2204	NM_001280539
RNF19A	hsa-miR-548ar-3p	88.0199	NM_015435
RNF19A	hsa-miR-4482-3p	87.2844	NM_015435
RNF19A	hsa-miR-29b-2-5p	86.7116	NM_001280539
RNF19A	hsa-miR-603	86.6343	NM_015435
RNF19A	hsa-miR-4310	86.6143	NM_015435
RNF19A	hsa-miR-2681-5p	85.9348	NM_015435
RNF19A	hsa-miR-10394-5p	85.8951	NM_001280539
RNF19A	hsa-miR-1205	85.8951	NM_001280539
RNF19A	hsa-miR-3121-3p	85.6741	NM_015435
RNF19A	hsa-miR-7-1-3p	85.6494	NM_001280539
RNF19A	hsa-miR-7-2-3p	85.6494	NM_001280539
RNF19A	hsa-miR-548x-3p	85.6251	NM_001280539
RNF19A	hsa-miR-548aj-3p	85.6251	NM_001280539
RNF19A	hsa-miR-548az-3p	85.2359	NM_015435
RNF19A	hsa-miR-548a-3p	85.2359	NM_015435
RNF19A	hsa-miR-548e-3p	85.2359	NM_015435

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Motifs and transcription factors (TFs) regulating RNF19A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RNF19A	transfac_pro__M00807	EGR1; EGR2; EGR3 (directAnnotation).
RNF19A	transfac_pro__M01104	OVOL2 (directAnnotation).
RNF19A	transfac_pro__M00986	CHURC1 (directAnnotation).
RNF19A	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
RNF19A	transfac_pro__M07310	SP5 (directAnnotation).
RNF19A	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RNF19A	transfac_pro__M03876	ZBTB33 (directAnnotation).
RNF19A	metacluster_135.11	NR2C2 (directAnnotation).
RNF19A	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RNF19A	tfdimers__MD00038	TFAP2C (directAnnotation).
RNF19A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RNF19A	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RNF19A	metacluster_198.3	ZFP64 (directAnnotation).
RNF19A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RNF19A	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RNF19A	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RNF19A	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RNF19A	cisbp__M00788	ZFY (inferredBy_Orthology).
RNF19A	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RNF19A	metacluster_175.1	ZNF283 (directAnnotation).
RNF19A	hdpi__ZNF304	ZNF304 (directAnnotation).
RNF19A	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RNF19A	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RNF19A	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RNF19A	transfac_pro__M01199	TRIM28 (directAnnotation).
RNF19A	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RNF19A	metacluster_151.2	ZNF23 (directAnnotation).
RNF19A	transfac_pro__M03806	ZBTB7C (directAnnotation).
RNF19A	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
RNF19A	cisbp__M01863	ZNF711 (inferredBy_Orthology).
RNF19A	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
RNF19A	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
RNF19A	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
RNF19A	transfac_pro__M05432	ZSCAN18 (directAnnotation).
RNF19A	transfac_pro__M02913	SP140 (inferredBy_Orthology).
RNF19A	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
RNF19A	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
RNF19A	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
RNF19A	transfac_pro__M00430	E2F1 (directAnnotation).
RNF19A	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
RNF19A	transfac_pro__M04893	TAF1 (directAnnotation).
RNF19A	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
RNF19A	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
RNF19A	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
RNF19A	hdpi__HIP2	UBE2K (directAnnotation).
RNF19A	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
RNF19A	hdpi__TIMELESS	TIMELESS (directAnnotation).
RNF19A	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
RNF19A	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
RNF19A	metacluster_191.5	SPDEF (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."