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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: RDX

Summary for RDX

Gene information	Gene symbol	RDX
	Ensembl ID	ENSG00000137710
	Entrez ID	5962
	Gene name	radixin
	Synonyms	DFNB24
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RDX

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.584673	2.38e-06
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.29232	3.60e-16
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.322439	2.21e-15
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.341933	1.28e-22
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.36144	0.00e+00
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.666683	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.423053	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.429283	1.84e-32
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	-0.412786	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.788159	0.00e+00

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Expression of RDX in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RDX

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RDX

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RDX	hsa-miR-8485	99.9298	NM_002906
RDX	hsa-miR-3613-3p	99.0559	NM_002906
RDX	hsa-miR-545-3p	98.5918	NM_002906
RDX	hsa-miR-501-5p	96.7297	NM_002906
RDX	hsa-miR-500a-5p	95.3453	NM_002906
RDX	hsa-miR-3529-3p	94.9081	NM_002906
RDX	hsa-miR-1283	94.6656	NM_002906
RDX	hsa-miR-6809-5p	93.7879	NM_002906
RDX	hsa-miR-6748-3p	93.6149	NM_001260492
RDX	hsa-miR-1275	93.4861	NM_001260492
RDX	hsa-miR-2682-5p	93.4426	NM_002906
RDX	hsa-miR-449c-5p	93.4426	NM_002906
RDX	hsa-miR-34b-5p	93.4426	NM_002906
RDX	hsa-miR-3614-5p	93.3556	NM_001260493
RDX	hsa-miR-5197-5p	92.3297	NM_002906
RDX	hsa-miR-7843-3p	91.556	NM_001260492
RDX	hsa-miR-551b-5p	90.8688	NM_002906
RDX	hsa-miR-6873-3p	90.5034	NM_002906
RDX	hsa-miR-346	90.4849	NM_002906
RDX	hsa-miR-4306	89.7884	NM_001260492
RDX	hsa-miR-577	89.714	NM_002906
RDX	hsa-miR-4665-5p	89.6731	NM_001260492
RDX	hsa-miR-676-5p	89.6297	NM_002906
RDX	hsa-miR-548au-3p	89.5418	NM_002906
RDX	hsa-let-7c-5p	89.2261	NM_002906
RDX	hsa-let-7e-5p	89.2261	NM_002906
RDX	hsa-miR-4500	89.2261	NM_002906
RDX	hsa-let-7a-5p	89.2261	NM_002906
RDX	hsa-miR-98-5p	89.2261	NM_002906
RDX	hsa-let-7b-5p	89.2261	NM_002906
RDX	hsa-miR-676-3p	89.0058	NM_002906
RDX	hsa-miR-4694-3p	88.922	NM_002906
RDX	hsa-miR-122b-3p	88.7089	NM_002906
RDX	hsa-miR-21-3p	88.7089	NM_002906
RDX	hsa-miR-4525	88.5044	NM_001260492
RDX	hsa-miR-5010-5p	88.5044	NM_001260492
RDX	hsa-miR-196a-5p	88.1829	NM_002906
RDX	hsa-miR-196b-5p	88.1829	NM_002906
RDX	hsa-miR-1277-5p	87.8157	NM_002906
RDX	hsa-miR-7110-3p	87.7102	NM_002906
RDX	hsa-miR-302e	87.5936	NM_002906
RDX	hsa-miR-1236-3p	87.4921	NM_002906
RDX	hsa-let-7i-5p	87.4508	NM_002906
RDX	hsa-let-7f-5p	87.4508	NM_002906
RDX	hsa-let-7g-5p	87.4508	NM_002906
RDX	hsa-let-7c-3p	86.4029	NM_002906
RDX	hsa-miR-103b	86.3575	NM_002906
RDX	hsa-miR-4666a-3p	86.3084	NM_001260492
RDX	hsa-miR-2355-3p	86.2741	NM_002906
RDX	hsa-miR-876-3p	85.6345	NM_002906

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Motifs and transcription factors (TFs) regulating RDX

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RDX	jaspar__MA1548.1	PLAGL2 (directAnnotation).
RDX	metacluster_22.36	BACH2 (directAnnotation).
RDX	metacluster_22.17	NFE2 (directAnnotation).
RDX	metacluster_22.19	NFE2 (directAnnotation).
RDX	transfac_public__M00491	PATZ1 (directAnnotation).
RDX	metacluster_135.11	NR2C2 (directAnnotation).
RDX	tfdimers__MD00038	TFAP2C (directAnnotation).
RDX	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RDX	cisbp__M00968	MTF2 (directAnnotation).
RDX	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RDX	cisbp__M00341	PAX6 (directAnnotation).
RDX	metacluster_198.3	ZFP64 (directAnnotation).
RDX	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RDX	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RDX	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RDX	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RDX	cisbp__M00788	ZFY (inferredBy_Orthology).
RDX	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RDX	metacluster_175.1	ZNF283 (directAnnotation).
RDX	hdpi__ZNF304	ZNF304 (directAnnotation).
RDX	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RDX	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RDX	transfac_pro__M01199	TRIM28 (directAnnotation).
RDX	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RDX	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RDX	transfac_pro__M03806	ZBTB7C (directAnnotation).
RDX	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RDX	hdpi__TP73	TP73 (directAnnotation).
RDX	swissregulon__hs__ETV6	ETV6 (directAnnotation).
RDX	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
RDX	transfac_pro__M04826	EP300 (directAnnotation).
RDX	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
RDX	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
RDX	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
RDX	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
RDX	transfac_pro__M01298	MECP2 (directAnnotation).
RDX	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
RDX	taipale_tf_pairs__MYBL1_EOMES_RSGTGNNNAACGK_CAP_repr	EOMES; MYBL1 (directAnnotation).
RDX	transfac_pro__M00492	STAT1 (directAnnotation).
RDX	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
RDX	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
RDX	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
RDX	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
RDX	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
RDX	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
RDX	metacluster_101.3	MYB (directAnnotation).
RDX	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
RDX	transfac_public__M00024	E2F1 (directAnnotation).
RDX	transfac_pro__M02913	SP140 (inferredBy_Orthology).
RDX	transfac_pro__M07483	CXXC1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
RDX	"1D-myo-inositol 1,4,5-trisphosphate"	DB03401	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."