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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RBPJ

Summary for RBPJ

Gene information	Gene symbol	RBPJ
	Ensembl ID	ENSG00000168214
	Entrez ID	3516
	Gene name	recombination signal binding protein for immunoglobulin kappa J region
	Synonyms	CBF1\|IGKJRB\|IGKJRB1\|KBF2\|RBP-J\|RBPJK\|RBPSUH\|SUH
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RBPJ

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	-0.252709	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.268898	2.00e-35
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.273817	2.26e-15
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.315559	2.52e-04
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.473101	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.497735	2.85e-13
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.975613	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	-0.506213	2.54e-24
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.497898	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.941226	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.449313	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.461785	0.00e+00

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Expression of RBPJ in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RBPJ

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
RBPJ	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating RBPJ

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RBPJ	hsa-miR-548x-3p	99.7353	NM_005349
RBPJ	hsa-miR-548aj-3p	99.7353	NM_005349
RBPJ	hsa-miR-548am-3p	99.7091	NM_005349
RBPJ	hsa-miR-548ah-3p	99.7091	NM_005349
RBPJ	hsa-miR-6720-5p	99.6457	NM_005349
RBPJ	hsa-miR-6512-3p	99.6457	NM_005349
RBPJ	hsa-miR-548j-3p	99.6223	NM_005349
RBPJ	hsa-miR-548ae-3p	99.6223	NM_005349
RBPJ	hsa-miR-548aq-3p	99.6223	NM_005349
RBPJ	hsa-miR-570-3p	98.8359	NM_203283
RBPJ	hsa-miR-9-3p	98.8254	NM_005349
RBPJ	hsa-miR-1283	98.6084	NM_005349
RBPJ	hsa-miR-4468	98.0084	NM_005349
RBPJ	hsa-miR-3941	97.8896	NM_203283
RBPJ	hsa-miR-3140-3p	97.3496	NM_005349
RBPJ	hsa-miR-6835-3p	97.2429	NM_005349
RBPJ	hsa-miR-21-5p	97.1701	NM_005349
RBPJ	hsa-miR-4666b	96.715	NM_203283
RBPJ	hsa-miR-590-5p	96.6698	NM_005349
RBPJ	hsa-miR-6739-3p	96.1116	NM_005349
RBPJ	hsa-miR-466	95.9635	NM_203283
RBPJ	hsa-miR-6849-3p	95.7955	NM_005349
RBPJ	hsa-miR-4672	95.1729	NM_203283
RBPJ	hsa-miR-6853-3p	94.8897	NM_005349
RBPJ	hsa-miR-8068	94.7618	NM_005349
RBPJ	hsa-miR-5688	94.6661	NM_203283
RBPJ	hsa-miR-495-3p	94.2849	NM_203283
RBPJ	hsa-miR-12136	94.2608	NM_203283
RBPJ	hsa-miR-4668-5p	93.9962	NM_203283
RBPJ	hsa-miR-8087	93.9388	NM_005349
RBPJ	hsa-miR-6740-3p	93.6561	NM_005349
RBPJ	hsa-miR-4318	93.5882	NM_005349
RBPJ	hsa-miR-548h-3p	93.5813	NM_203283
RBPJ	hsa-miR-548d-3p	93.5813	NM_203283
RBPJ	hsa-miR-548z	93.5813	NM_203283
RBPJ	hsa-miR-548ac	93.5813	NM_203283
RBPJ	hsa-miR-548bb-3p	93.5813	NM_203283
RBPJ	hsa-miR-6722-5p	93.3905	NM_005349
RBPJ	hsa-miR-15a-5p	93.3052	NM_005349
RBPJ	hsa-miR-15b-5p	93.3052	NM_005349
RBPJ	hsa-miR-424-5p	93.3052	NM_005349
RBPJ	hsa-miR-16-5p	93.3052	NM_005349
RBPJ	hsa-miR-497-5p	93.3052	NM_005349
RBPJ	hsa-miR-6838-5p	93.3052	NM_005349
RBPJ	hsa-miR-195-5p	93.3052	NM_005349
RBPJ	hsa-miR-375-3p	93.0837	NM_005349
RBPJ	hsa-miR-6811-5p	93.0578	NM_005349
RBPJ	hsa-miR-6511b-5p	93.0578	NM_005349
RBPJ	hsa-miR-636	92.9462	NM_005349
RBPJ	hsa-miR-3926	92.5749	NM_005349

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Motifs and transcription factors (TFs) regulating RBPJ

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RBPJ	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
RBPJ	transfac_pro__M01253	CNOT3 (directAnnotation).
RBPJ	metacluster_159.5	ZIC1; ZIC4; ZNF423 (directAnnotation). SP1 (inferredBy_Orthology).
RBPJ	cisbp__M00968	MTF2 (directAnnotation).
RBPJ	tfdimers__MD00038	TFAP2C (directAnnotation).
RBPJ	taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNGGCGCSN_CAP_repr	E2F3; TBX21 (directAnnotation).
RBPJ	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
RBPJ	transfac_pro__M01199	TRIM28 (directAnnotation).
RBPJ	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
RBPJ	metacluster_3.14	WT1; WT1 (directAnnotation).
RBPJ	transfac_pro__M12697	ZNF142 (directAnnotation).
RBPJ	metacluster_84.2	RARA (directAnnotation).
RBPJ	transfac_pro__M01122	ZNF219 (directAnnotation).
RBPJ	transfac_pro__M07387	ZBTB7A (directAnnotation).
RBPJ	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RBPJ	transfac_pro__M04893	TAF1 (directAnnotation).
RBPJ	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
RBPJ	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
RBPJ	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
RBPJ	kznf__EGR2_Barrera2016.3_PBM	EGR2 (directAnnotation).
RBPJ	metacluster_23.8	GLIS1; GLIS1; GLIS1; GLIS2; GLIS2; GLIS2; GLIS2 (directAnnotation). GLIS2; GLIS3; ZXDA; ZXDB; ZXDC (inferredBy_Orthology).
RBPJ	transfac_pro__M00986	CHURC1 (directAnnotation).
RBPJ	metacluster_182.2	GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (directAnnotation). GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (inferredBy_Orthology).
RBPJ	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RBPJ	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
RBPJ	taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNGGCGCSNNNNCRMN_CAP	E2F3; TBX21 (directAnnotation).
RBPJ	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
RBPJ	cisbp__M00249	WT1 (directAnnotation).
RBPJ	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
RBPJ	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
RBPJ	transfac_public__M00373	PAX4 (directAnnotation).
RBPJ	transfac_pro__M01714	KLF15 (directAnnotation).
RBPJ	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
RBPJ	cisbp__M00135	ZBTB7B (inferredBy_Orthology).
RBPJ	tfdimers__MD00366	MTF1; OVOL2 (directAnnotation).
RBPJ	transfac_pro__M00938	E2F1 (directAnnotation).
RBPJ	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RBPJ	transfac_pro__M12667	GPBP1L1 (directAnnotation).
RBPJ	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
RBPJ	transfac_pro__M07310	SP5 (directAnnotation).
RBPJ	cisbp__M00341	PAX6 (directAnnotation).
RBPJ	swissregulon__hs__PATZ1	PATZ1 (directAnnotation).
RBPJ	metacluster_159.3	ARID3A; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCFL; CTCFL; CTCFL; CTCFL; CTCFL; CTCFL; CTCFL; CTCFL; HMGXB4; KLF16; MBD1; RAD21; RAD21; RAD21; RXRA; SMC3; SMC3; ZNF576; ZNF654; ZNF764 (directAnnotation). CTCF; CTCF; CTCF; CTCF; CTCFL (inferredBy_Orthology).
RBPJ	transfac_pro__M08818	KLF8 (directAnnotation).
RBPJ	kznf__ZNF311_Imbeault2017_RP_ChIP-seq	ZNF311 (directAnnotation).
RBPJ	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
RBPJ	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RBPJ	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
RBPJ	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
RBPJ	jaspar__MA1721.1	ZNF93 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."