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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RBM38

Summary for RBM38

Gene information	Gene symbol	RBM38
	Ensembl ID	ENSG00000132819
	Entrez ID	55544
	Gene name	RNA binding motif protein 38
	Synonyms	dJ800J21.2\|HSRNASEB\|RNPC1\|seb4B\|SEB4D
	Gene type	protein_coding
	UniProtAcc	Q9H0Z9

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Dataset with differentially expressed gene: RBM38

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	-0.260397	4.67e-21
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.625731	4.35e-34
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD4+ T cells	-0.309334	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	NK cells	-0.307839	3.97e-04
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	B cells	-0.404861	7.21e-17
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.402355	4.20e-45
GSE212217	patients	Peripheral blood mononuclear cells	Endometrial cancer	Epigenetic MMRd endometrial carcinoma	Immunotherapy	pembrolizumab	post	B cells	0.357757	1.32e-42
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	CD8+ T cells	0.318819	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	CD4+ T cells	0.315768	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD8+ T cells	-0.438858	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD8+ T cells	-0.423672	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	NK cells	-0.360718	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	CD8+ T cells	0.529323	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-1.15519	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.774743	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.463655	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.643012	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.12102	1.51e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.264889	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.442158	0.00e+00

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Expression of RBM38 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RBM38

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RBM38

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RBM38	hsa-miR-3649	91.717	NM_017495
RBM38	hsa-miR-6769b-5p	88.2633	NM_183425
RBM38	hsa-miR-6763-5p	88.2343	NM_017495
RBM38	hsa-miR-6769a-5p	85.2651	NM_183425
RBM38	hsa-miR-589-3p	85.0279	NM_017495
RBM38	hsa-miR-6829-5p	82.9875	NM_183425
RBM38	hsa-miR-3150a-3p	82.9451	NM_017495
RBM38	hsa-miR-576-5p	81.3931	NM_017495
RBM38	hsa-miR-3691-3p	80.1736	NM_017495

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Motifs and transcription factors (TFs) regulating RBM38

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RBM38	tfdimers__MD00269	CRX; PBX1 (directAnnotation).
RBM38	transfac_pro__M04810	USF2 (directAnnotation).
RBM38	hocomoco__FOXP1_HUMAN.H11MO.0.A	FOXP1 (directAnnotation).
RBM38	metacluster_187.5	MYNN (directAnnotation).
RBM38	metacluster_127.3	FOXO1; FOXO3; FOXO4 (directAnnotation).
RBM38	homer__ATTGCGCAAC_CEBP	CEBPB (inferredBy_Orthology).
RBM38	transfac_pro__M01968	FOXO1 (directAnnotation).
RBM38	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
RBM38	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
RBM38	metacluster_141.2	E2F2; E2F3 (directAnnotation).
RBM38	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
RBM38	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
RBM38	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
RBM38	transfac_pro__M06035	ZNF749 (directAnnotation).
RBM38	taipale_tf_pairs__TFAP2C_ONECUT2_NATCGATNNNNNNNGCCTNNGGSNN_CAP_repr	ONECUT2; TFAP2C (directAnnotation).
RBM38	hdpi__YEATS4	YEATS4 (directAnnotation).
RBM38	transfac_pro__M06388	ZNF677 (directAnnotation).
RBM38	metacluster_84.14	RARG (directAnnotation).
RBM38	taipale_tf_pairs__GCM1_FIGLA_CAGCTGNNNNNNNNNTGCGGG_CAP	FIGLA; GCM1 (directAnnotation).
RBM38	transfac_pro__M06951	TEF (directAnnotation).
RBM38	transfac_pro__M04890	BATF (directAnnotation).
RBM38	taipale_tf_pairs__TEAD4_GSC2_RGWATGTTAATCCS_CAP_repr	GSC2; TEAD4 (directAnnotation).
RBM38	transfac_pro__M04746	E2F1 (directAnnotation).
RBM38	transfac_pro__M05672	ZNF133 (directAnnotation).
RBM38	metacluster_130.15	ARID5B; ARID5B; BPTF (directAnnotation).
RBM38	metacluster_63.4	ZNF672 (directAnnotation).
RBM38	transfac_pro__M04933	STAT3 (directAnnotation).
RBM38	taipale_cyt_meth__LBX2_CTCGTTAN_eDBD	LBX2 (directAnnotation).
RBM38	transfac_pro__M06818	ZNF592 (inferredBy_Orthology).
RBM38	metacluster_102.2	ZBED1 (directAnnotation).
RBM38	taipale_tf_pairs__FOXO1_ELF1_NNGAAAACCGAANM_CAP	ELF1; FOXO1 (directAnnotation).
RBM38	tfdimers__MD00208	IRF1; LTF (directAnnotation).
RBM38	transfac_pro__M06375	ZNF629 (inferredBy_Orthology).
RBM38	transfac_pro__M06426	ZNF761 (directAnnotation).
RBM38	transfac_pro__M05976	ZNF223 (directAnnotation).
RBM38	transfac_pro__M06104	ZNF16 (directAnnotation).
RBM38	transfac_pro__M06259	ZNF91 (directAnnotation).
RBM38	cisbp__M01815	CEBPE (inferredBy_Orthology).
RBM38	metacluster_46.4	CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; DBP; DBP; EP300; GATAD2A; HES2 (directAnnotation). CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; HLF; HLF (inferredBy_Orthology).
RBM38	transfac_pro__M05473	SALL4 (directAnnotation).
RBM38	transfac_pro__M05993	ZNF711 (directAnnotation).
RBM38	tfdimers__MD00216	ARID3A; VDR (directAnnotation).
RBM38	kznf__ZNF382_Najafabadi2015_ChIP-seq	ZNF382 (directAnnotation).
RBM38	metacluster_147.4	SMAD2; SMAD3; SMAD4; SMAD4 (directAnnotation).
RBM38	metacluster_165.10	HOXA1; HOXA2; HOXB1; HOXB1; PBX1; PBX1; PBX2; PBX2 (directAnnotation). HOXA1 (inferredBy_Orthology).
RBM38	metacluster_168.4	ZNF652 (directAnnotation).
RBM38	taipale_tf_pairs__TEAD4_DLX3_RCATTCCNNNNTAATKR_CAP	DLX3; TEAD4 (directAnnotation).
RBM38	taipale_tf_pairs__TEAD4_HOXA3_RCATTCYNNNNNCATTA_CAP	HOXA3; TEAD4 (directAnnotation).
RBM38	transfac_public__M00208	NFKB1; RELA (directAnnotation).
RBM38	transfac_pro__M04886	ETS1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."