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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAP2B

Summary for RAP2B

Gene information	Gene symbol	RAP2B
	Ensembl ID	ENSG00000181467
	Entrez ID	5912
	Gene name	RAP2B, member of RAS oncogene family
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P61225

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Dataset with differentially expressed gene: RAP2B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.255934	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.376065	1.43e-12
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.398977	2.79e-20
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.914713	3.82e-20
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.45166	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.344971	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.69415	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.675565	0.00e+00

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Expression of RAP2B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAP2B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAP2B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAP2B	hsa-miR-499a-3p	95.3407	NM_002886
RAP2B	hsa-miR-499b-3p	95.3407	NM_002886
RAP2B	hsa-miR-3662	94.7004	NM_002886
RAP2B	hsa-miR-519d-5p	93.3534	NM_002886
RAP2B	hsa-miR-302b-5p	93.151	NM_002886
RAP2B	hsa-miR-302d-5p	93.151	NM_002886
RAP2B	hsa-miR-5582-3p	91.6898	NM_002886
RAP2B	hsa-miR-8485	91.2419	NM_002886
RAP2B	hsa-miR-4282	91.0481	NM_002886
RAP2B	hsa-miR-515-5p	90.6746	NM_002886
RAP2B	hsa-miR-7856-5p	90.038	NM_002886
RAP2B	hsa-miR-4642	89.7713	NM_002886
RAP2B	hsa-miR-519e-5p	89.4723	NM_002886
RAP2B	hsa-miR-3613-3p	87.9197	NM_002886
RAP2B	hsa-miR-3692-3p	87.6794	NM_002886
RAP2B	hsa-miR-5680	87.1104	NM_002886
RAP2B	hsa-miR-6791-3p	86.6163	NM_002886
RAP2B	hsa-miR-6829-3p	86.6163	NM_002886
RAP2B	hsa-miR-513a-5p	86.2463	NM_002886
RAP2B	hsa-miR-23b-3p	85.6653	NM_002886
RAP2B	hsa-miR-23a-3p	85.6653	NM_002886
RAP2B	hsa-miR-23c	85.6653	NM_002886
RAP2B	hsa-miR-330-3p	85.4201	NM_002886
RAP2B	hsa-miR-138-2-3p	83.2679	NM_002886
RAP2B	hsa-miR-3646	82.6914	NM_002886
RAP2B	hsa-miR-3910	82.097	NM_002886
RAP2B	hsa-miR-4760-3p	81.5974	NM_002886
RAP2B	hsa-miR-3121-3p	81.273	NM_002886
RAP2B	hsa-miR-7158-5p	80.8326	NM_002886
RAP2B	hsa-miR-1264	80.6288	NM_002886
RAP2B	hsa-miR-6881-3p	80.1994	NM_002886
RAP2B	hsa-miR-3658	80.0711	NM_002886
RAP2B	hsa-miR-205-5p	80.0094	NM_002886

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Motifs and transcription factors (TFs) regulating RAP2B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAP2B	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RAP2B	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RAP2B	transfac_pro__M03806	ZBTB7C (directAnnotation).
RAP2B	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RAP2B	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
RAP2B	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
RAP2B	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
RAP2B	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
RAP2B	jaspar__MA1721.1	ZNF93 (directAnnotation).
RAP2B	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
RAP2B	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
RAP2B	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
RAP2B	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
RAP2B	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
RAP2B	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
RAP2B	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
RAP2B	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
RAP2B	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
RAP2B	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RAP2B	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
RAP2B	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
RAP2B	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
RAP2B	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
RAP2B	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
RAP2B	transfac_pro__M07310	SP5 (directAnnotation).
RAP2B	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RAP2B	transfac_pro__M00938	E2F1 (directAnnotation).
RAP2B	transfac_pro__M04893	TAF1 (directAnnotation).
RAP2B	transfac_pro__M04817	ZBTB33 (directAnnotation).
RAP2B	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
RAP2B	transfac_pro__M12697	ZNF142 (directAnnotation).
RAP2B	tfdimers__MD00364	WT1 (directAnnotation).
RAP2B	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
RAP2B	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
RAP2B	tfdimers__MD00483	ZBTB14 (directAnnotation).
RAP2B	transfac_pro__M01303	SP1 (directAnnotation).
RAP2B	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
RAP2B	tfdimers__MD00552	USF2; ZBTB14 (directAnnotation).
RAP2B	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
RAP2B	transfac_pro__M07387	ZBTB7A (directAnnotation).
RAP2B	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
RAP2B	metacluster_144.13	HIC1; HIC1 (directAnnotation).
RAP2B	transfac_pro__M00665	SP3 (directAnnotation).
RAP2B	transfac_pro__M02898	SMAD3 (directAnnotation).
RAP2B	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
RAP2B	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
RAP2B	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
RAP2B	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
RAP2B	transfac_pro__M07329	SP7 (directAnnotation).
RAP2B	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."