Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: RAB7A

Summary for RAB7A

Gene information	Gene symbol	RAB7A
	Ensembl ID	ENSG00000075785
	Entrez ID	7879
	Gene name	RAB7A, member RAS oncogene family
	Synonyms	CMT2B\|RAB7
	Gene type	protein_coding
	UniProtAcc	P51149

Top

Dataset with differentially expressed gene: RAB7A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.355683	5.72e-19
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.453034	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.329648	3.48e-06
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.290921	1.13e-21
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	cDCs	0.299125	4.50e-05
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.284564	3.32e-02
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.328804	2.00e-07
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.261142	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.468473	1.86e-36
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.417101	5.01e-18
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.370534	9.40e-19
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.418635	3.22e-18
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.494106	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.330791	4.33e-21

Top

Expression of RAB7A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to RAB7A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating RAB7A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB7A	hsa-miR-6867-5p	100	NM_004637
RAB7A	hsa-miR-3148	96.2107	NM_004637
RAB7A	hsa-miR-6766-5p	95.9446	NM_004637
RAB7A	hsa-miR-3614-3p	95.5785	NM_004637
RAB7A	hsa-miR-6756-5p	94.6777	NM_004637
RAB7A	hsa-miR-4753-3p	93.9565	NM_004637
RAB7A	hsa-miR-4677-5p	92.5037	NM_004637
RAB7A	hsa-miR-8057	90.9225	NM_004637
RAB7A	hsa-miR-448	90.5894	NM_004637
RAB7A	hsa-miR-4493	90.31	NM_004637
RAB7A	hsa-miR-6795-5p	89.9079	NM_004637
RAB7A	hsa-miR-6887-5p	89.9079	NM_004637
RAB7A	hsa-miR-4764-5p	89.5772	NM_004637
RAB7A	hsa-miR-1207-3p	86.9158	NM_004637
RAB7A	hsa-miR-6763-5p	86.7886	NM_004637
RAB7A	hsa-miR-548n	86.3673	NM_004637
RAB7A	hsa-miR-1183	85.6858	NM_004637
RAB7A	hsa-miR-581	85.3588	NM_004637
RAB7A	hsa-miR-655-5p	85.2133	NM_004637
RAB7A	hsa-miR-3135b	85.0128	NM_004637
RAB7A	hsa-miR-6734-3p	84.8991	NM_004637
RAB7A	hsa-miR-3920	84.7081	NM_004637
RAB7A	hsa-miR-4483	84.564	NM_004637
RAB7A	hsa-miR-583	84.4933	NM_004637
RAB7A	hsa-miR-548c-3p	83.0775	NM_004637
RAB7A	hsa-miR-4492	82.9658	NM_004637
RAB7A	hsa-miR-3150a-3p	82.2209	NM_004637
RAB7A	hsa-miR-6783-5p	81.5918	NM_004637
RAB7A	hsa-miR-4735-5p	81.3819	NM_004637
RAB7A	hsa-miR-590-3p	81.0751	NM_004637
RAB7A	hsa-miR-199a-5p	80.7342	NM_004637
RAB7A	hsa-miR-199b-5p	80.7342	NM_004637
RAB7A	hsa-miR-627-3p	80.5343	NM_004637
RAB7A	hsa-miR-1825	80.3039	NM_004637

Page: 1

Top

Motifs and transcription factors (TFs) regulating RAB7A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB7A	transfac_pro__M01199	TRIM28 (directAnnotation).
RAB7A	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RAB7A	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RAB7A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RAB7A	transfac_pro__M03806	ZBTB7C (directAnnotation).
RAB7A	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RAB7A	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
RAB7A	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
RAB7A	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
RAB7A	jaspar__MA0748.2	YY2 (directAnnotation).
RAB7A	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
RAB7A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RAB7A	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
RAB7A	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
RAB7A	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
RAB7A	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
RAB7A	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
RAB7A	swissregulon__hs__GLIS2	GLIS2 (directAnnotation).
RAB7A	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
RAB7A	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
RAB7A	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
RAB7A	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
RAB7A	transfac_pro__M01253	CNOT3 (directAnnotation).
RAB7A	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
RAB7A	metacluster_3.10	KLF2; KLF4 (directAnnotation).
RAB7A	jaspar__MA1721.1	ZNF93 (directAnnotation).
RAB7A	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RAB7A	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RAB7A	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
RAB7A	jaspar__MA1122.1	TFDP1 (directAnnotation).
RAB7A	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
RAB7A	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWGNNNNNTCCGGNN_CAP	GCM1; SPDEF (directAnnotation).
RAB7A	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
RAB7A	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
RAB7A	tfdimers__MD00151	CHURC1 (directAnnotation).
RAB7A	tfdimers__MD00391	KLF4 (directAnnotation).
RAB7A	tfdimers__MD00441	OVOL2; RELA (directAnnotation).
RAB7A	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
RAB7A	transfac_pro__M01973	PLAG1 (directAnnotation).
RAB7A	transfac_pro__M12697	ZNF142 (directAnnotation).
RAB7A	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
RAB7A	transfac_pro__M01303	SP1 (directAnnotation).
RAB7A	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
RAB7A	metacluster_3.14	WT1; WT1 (directAnnotation).
RAB7A	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
RAB7A	hdpi__TP73	TP73 (directAnnotation).
RAB7A	hdpi__ELF2	ELF2 (directAnnotation).
RAB7A	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
RAB7A	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
RAB7A	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).

Page: 1 2 3

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
RAB7A	"Guanosine-5'-Diphosphate"	DB04315	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."