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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAB14

Summary for RAB14

Gene information	Gene symbol	RAB14
	Ensembl ID	ENSG00000119396
	Entrez ID	51552
	Gene name	RAB14, member RAS oncogene family
	Synonyms	FBP\|RAB-14
	Gene type	protein_coding
	UniProtAcc	P61106

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Dataset with differentially expressed gene: RAB14

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.321093	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.33809	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.282221	5.49e-38
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.404807	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.318247	0.00e+00

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Expression of RAB14 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAB14

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
RAB14	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating RAB14

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB14	hsa-miR-4789-5p	99.1196	NM_016322
RAB14	hsa-miR-338-3p	95.553	NM_016322
RAB14	hsa-miR-12136	95.4415	NM_016322
RAB14	hsa-miR-4311	95.2635	NM_016322
RAB14	hsa-miR-4722-5p	95.2451	NM_016322
RAB14	hsa-miR-4699-3p	94.9722	NM_016322
RAB14	hsa-miR-4426	94.8877	NM_016322
RAB14	hsa-miR-4274	94.5524	NM_016322
RAB14	hsa-miR-4672	94.4743	NM_016322
RAB14	hsa-miR-548c-3p	94.4001	NM_016322
RAB14	hsa-miR-5587-5p	94.0506	NM_016322
RAB14	hsa-miR-7854-3p	93.9903	NM_016322
RAB14	hsa-miR-4777-5p	92.2899	NM_016322
RAB14	hsa-miR-4662b	92.0176	NM_016322
RAB14	hsa-miR-4647	92.0176	NM_016322
RAB14	hsa-miR-3619-5p	91.8898	NM_016322
RAB14	hsa-miR-3120-3p	91.4746	NM_016322
RAB14	hsa-miR-4429	91.1811	NM_016322
RAB14	hsa-miR-320d	91.1811	NM_016322
RAB14	hsa-miR-320b	91.1811	NM_016322
RAB14	hsa-miR-320c	91.1811	NM_016322
RAB14	hsa-miR-320a-3p	91.1811	NM_016322
RAB14	hsa-miR-3119	90.9378	NM_016322
RAB14	hsa-miR-5195-3p	90.9196	NM_016322
RAB14	hsa-miR-374b-3p	90.3708	NM_016322
RAB14	hsa-miR-1286	90.2698	NM_016322
RAB14	hsa-miR-6730-5p	89.4216	NM_016322
RAB14	hsa-miR-214-3p	89.3193	NM_016322
RAB14	hsa-miR-761	89.3193	NM_016322
RAB14	hsa-miR-6768-5p	89.2425	NM_016322
RAB14	hsa-miR-145-5p	89.0927	NM_016322
RAB14	hsa-miR-548g-3p	88.8806	NM_016322
RAB14	hsa-miR-524-5p	88.7849	NM_016322
RAB14	hsa-miR-520d-5p	88.7849	NM_016322
RAB14	hsa-miR-98-3p	88.5924	NM_016322
RAB14	hsa-miR-3974	88.4908	NM_016322
RAB14	hsa-miR-9-3p	88.4796	NM_016322
RAB14	hsa-miR-1915-5p	88.4149	NM_016322
RAB14	hsa-miR-10523-5p	88.2865	NM_016322
RAB14	hsa-miR-4446-5p	88.2393	NM_016322
RAB14	hsa-miR-627-3p	88.022	NM_016322
RAB14	hsa-miR-92a-3p	87.8799	NM_016322
RAB14	hsa-miR-32-5p	87.8799	NM_016322
RAB14	hsa-miR-92b-3p	87.8799	NM_016322
RAB14	hsa-miR-500a-3p	87.6259	NM_016322
RAB14	hsa-miR-1537-3p	87.5231	NM_016322
RAB14	hsa-miR-25-3p	86.8196	NM_016322
RAB14	hsa-miR-367-3p	86.8196	NM_016322
RAB14	hsa-miR-363-3p	86.8196	NM_016322
RAB14	hsa-miR-4503	86.8003	NM_016322

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Motifs and transcription factors (TFs) regulating RAB14

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB14	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RAB14	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
RAB14	cisbp__M00249	WT1 (directAnnotation).
RAB14	metacluster_182.10	ZFX (directAnnotation).
RAB14	hdpi__ZNF304	ZNF304 (directAnnotation).
RAB14	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
RAB14	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
RAB14	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
RAB14	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RAB14	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RAB14	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
RAB14	metacluster_151.2	ZNF23 (directAnnotation).
RAB14	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
RAB14	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
RAB14	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RAB14	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
RAB14	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
RAB14	transfac_pro__M01253	CNOT3 (directAnnotation).
RAB14	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
RAB14	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RAB14	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
RAB14	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RAB14	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
RAB14	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
RAB14	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RAB14	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
RAB14	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
RAB14	transfac_pro__M04817	ZBTB33 (directAnnotation).
RAB14	transfac_pro__M12697	ZNF142 (directAnnotation).
RAB14	metacluster_175.1	ZNF283 (directAnnotation).
RAB14	tfdimers__MD00364	WT1 (directAnnotation).
RAB14	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
RAB14	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RAB14	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
RAB14	transfac_pro__M01973	PLAG1 (directAnnotation).
RAB14	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
RAB14	tfdimers__MD00483	ZBTB14 (directAnnotation).
RAB14	metacluster_198.3	ZFP64 (directAnnotation).
RAB14	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
RAB14	transfac_pro__M01303	SP1 (directAnnotation).
RAB14	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
RAB14	metacluster_143.13	ZBTB7A (directAnnotation).
RAB14	tfdimers__MD00552	USF2; ZBTB14 (directAnnotation).
RAB14	taipale_tf_pairs__ETV5_EOMES_RNGTGNNNNNNNNNNNNNRCRCCGGAWSN_CAP	EOMES; ETV5 (directAnnotation).
RAB14	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
RAB14	transfac_pro__M07387	ZBTB7A (directAnnotation).
RAB14	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
RAB14	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
RAB14	metacluster_144.13	HIC1; HIC1 (directAnnotation).
RAB14	transfac_pro__M00514	ATF4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."