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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PUM1

Summary for PUM1

Gene information	Gene symbol	PUM1
	Ensembl ID	ENSG00000134644
	Entrez ID	9698
	Gene name	pumilio RNA binding family member 1
	Synonyms	KIAA0099\|PUMH1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PUM1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.495719	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.329962	1.22e-41
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.414509	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.269251	0.00e+00

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Expression of PUM1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PUM1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PUM1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PUM1	hsa-miR-5011-5p	100	NM_001020658
PUM1	hsa-miR-190a-3p	100	NM_001020658
PUM1	hsa-miR-4789-5p	99.9645	NM_001020658
PUM1	hsa-let-7c-3p	99.4222	NM_001020658
PUM1	hsa-miR-323a-3p	99.3958	NM_001020658
PUM1	hsa-miR-548aw	99.008	NM_001020658
PUM1	hsa-miR-4801	97.8948	NM_001020658
PUM1	hsa-miR-1468-3p	96.9121	NM_001020658
PUM1	hsa-miR-4731-3p	96.9006	NM_001020658
PUM1	hsa-miR-2053	96.1276	NM_001020658
PUM1	hsa-miR-511-3p	95.6322	NM_001020658
PUM1	hsa-miR-4704-5p	94.8554	NM_001020658
PUM1	hsa-miR-548x-5p	94.8428	NM_001020658
PUM1	hsa-miR-548aj-5p	94.8428	NM_001020658
PUM1	hsa-miR-548g-5p	94.8428	NM_001020658
PUM1	hsa-miR-548f-5p	94.8428	NM_001020658
PUM1	hsa-miR-7849-3p	94.8353	NM_001020658
PUM1	hsa-miR-3182	94.178	NM_001020658
PUM1	hsa-miR-6768-5p	94.0175	NM_001020658
PUM1	hsa-let-7b-3p	93.5081	NM_001020658
PUM1	hsa-let-7a-3p	93.5081	NM_001020658
PUM1	hsa-let-7f-1-3p	93.5081	NM_001020658
PUM1	hsa-miR-98-3p	93.5081	NM_001020658
PUM1	hsa-miR-3529-3p	93.5043	NM_001020658
PUM1	hsa-miR-6132	93.402	NM_001020658
PUM1	hsa-miR-6836-5p	93.402	NM_001020658
PUM1	hsa-miR-3133	93.1189	NM_001020658
PUM1	hsa-miR-519d-5p	92.546	NM_001020658
PUM1	hsa-miR-4742-3p	92.296	NM_001020658
PUM1	hsa-miR-524-5p	92.2567	NM_001020658
PUM1	hsa-miR-520d-5p	92.2567	NM_001020658
PUM1	hsa-miR-3613-3p	91.9749	NM_001020658
PUM1	hsa-miR-4327	91.8269	NM_001020658
PUM1	hsa-miR-5093	91.6786	NM_001020658
PUM1	hsa-miR-340-5p	91.2642	NM_001020658
PUM1	hsa-miR-651-5p	91.0423	NM_001020658
PUM1	hsa-miR-10397-3p	90.7507	NM_001020658
PUM1	hsa-miR-6841-5p	90.5277	NM_001020658
PUM1	hsa-miR-4645-3p	90.2691	NM_001020658
PUM1	hsa-miR-345-3p	89.2395	NM_001020658
PUM1	hsa-miR-3159	88.1174	NM_001020658
PUM1	hsa-miR-186-5p	87.6971	NM_001020658
PUM1	hsa-miR-2054	86.9345	NM_001020658
PUM1	hsa-miR-3692-3p	86.6668	NM_001020658
PUM1	hsa-miR-8068	86.09	NM_001020658
PUM1	hsa-miR-29b-1-5p	85.633	NM_001020658
PUM1	hsa-miR-34b-5p	84.6317	NM_001020658
PUM1	hsa-miR-449c-5p	84.6317	NM_001020658
PUM1	hsa-miR-145-3p	84.5258	NM_001020658
PUM1	hsa-miR-4666a-5p	84.3817	NM_001020658

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Motifs and transcription factors (TFs) regulating PUM1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PUM1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PUM1	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
PUM1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
PUM1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
PUM1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PUM1	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
PUM1	transfac_pro__M07310	SP5 (directAnnotation).
PUM1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
PUM1	transfac_pro__M00938	E2F1 (directAnnotation).
PUM1	transfac_pro__M04893	TAF1 (directAnnotation).
PUM1	transfac_pro__M04817	ZBTB33 (directAnnotation).
PUM1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
PUM1	transfac_pro__M12697	ZNF142 (directAnnotation).
PUM1	metacluster_175.1	ZNF283 (directAnnotation).
PUM1	cisbp__M00788	ZFY (inferredBy_Orthology).
PUM1	tfdimers__MD00364	WT1 (directAnnotation).
PUM1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
PUM1	hdpi__ZNF304	ZNF304 (directAnnotation).
PUM1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
PUM1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PUM1	transfac_pro__M04916	TAF1 (directAnnotation).
PUM1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
PUM1	tfdimers__MD00483	ZBTB14 (directAnnotation).
PUM1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PUM1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
PUM1	transfac_pro__M07387	ZBTB7A (directAnnotation).
PUM1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
PUM1	metacluster_144.13	HIC1; HIC1 (directAnnotation).
PUM1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PUM1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PUM1	transfac_pro__M02898	SMAD3 (directAnnotation).
PUM1	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
PUM1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PUM1	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
PUM1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
PUM1	transfac_pro__M07329	SP7 (directAnnotation).
PUM1	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
PUM1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PUM1	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
PUM1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
PUM1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PUM1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
PUM1	jaspar__MA1122.1	TFDP1 (directAnnotation).
PUM1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
PUM1	tfdimers__MD00151	CHURC1 (directAnnotation).
PUM1	tfdimers__MD00391	KLF4 (directAnnotation).
PUM1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
PUM1	metacluster_3.14	WT1; WT1 (directAnnotation).
PUM1	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."