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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PSMC2

Summary for PSMC2

Gene information	Gene symbol	PSMC2
	Ensembl ID	ENSG00000161057
	Entrez ID	5701
	Gene name	proteasome 26S subunit, ATPase 2
	Synonyms	MSS1\|Nbla10058\|RPT1\|S7
	Gene type	protein_coding
	UniProtAcc	P35998

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Dataset with differentially expressed gene: PSMC2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.346397	1.76e-02
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.590584	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.302792	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.532589	3.25e-34
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.505073	3.21e-17
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.506207	5.57e-26
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.445888	9.93e-17
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.389261	2.86e-23

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Expression of PSMC2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PSMC2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PSMC2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PSMC2	hsa-miR-4786-3p	96.3625	NM_002803
PSMC2	hsa-miR-3613-3p	95.1013	NM_002803
PSMC2	hsa-miR-3135a	94.3708	NM_002803
PSMC2	hsa-miR-590-3p	94.247	NM_002803
PSMC2	hsa-miR-7843-3p	94.2192	NM_002803
PSMC2	hsa-miR-1290	93.3728	NM_002803
PSMC2	hsa-miR-891b	92.0765	NM_002803
PSMC2	hsa-miR-3177-5p	91.2841	NM_002803
PSMC2	hsa-miR-630	91.2471	NM_001204453
PSMC2	hsa-miR-95-5p	90.6581	NM_002803
PSMC2	hsa-miR-559	89.8911	NM_002803
PSMC2	hsa-miR-548j-5p	89.8249	NM_002803
PSMC2	hsa-miR-548ar-5p	89.8249	NM_002803
PSMC2	hsa-miR-548o-5p	89.8249	NM_002803
PSMC2	hsa-miR-548d-5p	89.8249	NM_002803
PSMC2	hsa-miR-548c-5p	89.8249	NM_002803
PSMC2	hsa-miR-548ak	89.8249	NM_002803
PSMC2	hsa-miR-548bb-5p	89.8249	NM_002803
PSMC2	hsa-miR-548ae-5p	89.8249	NM_002803
PSMC2	hsa-miR-548ad-5p	89.8249	NM_002803
PSMC2	hsa-miR-548ay-5p	89.8249	NM_002803
PSMC2	hsa-miR-548ab	89.8249	NM_002803
PSMC2	hsa-miR-548au-5p	89.8249	NM_002803
PSMC2	hsa-miR-548i	89.8249	NM_002803
PSMC2	hsa-miR-548as-5p	89.8249	NM_002803
PSMC2	hsa-miR-548y	89.8249	NM_002803
PSMC2	hsa-miR-548ap-5p	89.8249	NM_002803
PSMC2	hsa-miR-548a-5p	89.8249	NM_002803
PSMC2	hsa-miR-548b-5p	89.8249	NM_002803
PSMC2	hsa-miR-548am-5p	89.8249	NM_002803
PSMC2	hsa-miR-548h-5p	89.8249	NM_002803
PSMC2	hsa-miR-548w	89.8249	NM_002803
PSMC2	hsa-miR-548aq-5p	89.7677	NM_002803
PSMC2	hsa-miR-3662	89.701	NM_002803
PSMC2	hsa-miR-3201	88.0457	NM_001204453
PSMC2	hsa-miR-1250-3p	87.4581	NM_002803
PSMC2	hsa-miR-1305	86.6623	NM_001204453
PSMC2	hsa-miR-3606-5p	86.5492	NM_001204453
PSMC2	hsa-miR-664a-3p	86.3638	NM_002803
PSMC2	hsa-miR-5001-3p	85.4822	NM_002803
PSMC2	hsa-miR-670-3p	84.0715	NM_002803
PSMC2	hsa-miR-4791	82.4832	NM_001204453
PSMC2	hsa-miR-6738-3p	82.1712	NM_002803
PSMC2	hsa-miR-5197-3p	81.819	NM_002803
PSMC2	hsa-miR-298	80.9053	NM_001204453
PSMC2	hsa-miR-4714-5p	80.5492	NM_001204453

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Motifs and transcription factors (TFs) regulating PSMC2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PSMC2	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
PSMC2	taipale_tf_pairs__HOXB2_PAX9_NNMATTAGTCACGCWTSRNTG_CAP	HOXB2; PAX9 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."