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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PSIP1

Summary for PSIP1

Gene information	Gene symbol	PSIP1
	Ensembl ID	ENSG00000164985
	Entrez ID	11168
	Gene name	PC4 and SFRS1 interacting protein 1
	Synonyms	DFS70\|LEDGF\|p52\|p75\|PSIP2
	Gene type	protein_coding
	UniProtAcc	O75475

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Dataset with differentially expressed gene: PSIP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.487809	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.438476	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.32958	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.459502	0.00e+00
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	-0.269556	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.436786	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.34129	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.553367	3.92e-02
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD4+ T cells	-0.344676	9.92e-04
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.332298	3.29e-12
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.296888	2.69e-42
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.574585	0.00e+00

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Expression of PSIP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PSIP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PSIP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PSIP1	hsa-miR-607	98.2685	NM_001128217
PSIP1	hsa-miR-1323	96.3523	NM_001128217
PSIP1	hsa-miR-3143	96.2613	NM_001128217
PSIP1	hsa-miR-2117	94.9814	NM_001128217
PSIP1	hsa-miR-4288	94.6291	NM_001128217
PSIP1	hsa-miR-548o-3p	94.4793	NM_001128217
PSIP1	hsa-miR-12123	94.3968	NM_001128217
PSIP1	hsa-miR-4328	94.2746	NM_001128217
PSIP1	hsa-miR-4518	94.0915	NM_021144
PSIP1	hsa-miR-543	93.7254	NM_001128217
PSIP1	hsa-miR-4744	93.5344	NM_021144
PSIP1	hsa-miR-6508-5p	93.5077	NM_001128217
PSIP1	hsa-miR-1266-5p	93.0518	NM_021144
PSIP1	hsa-miR-548c-3p	92.9727	NM_001128217
PSIP1	hsa-miR-708-3p	92.8389	NM_001128217
PSIP1	hsa-miR-570-3p	92.7057	NM_001128217
PSIP1	hsa-miR-585-5p	92.6374	NM_001128217
PSIP1	hsa-miR-8067	92.5636	NM_001128217
PSIP1	hsa-miR-509-3-5p	92.2604	NM_001128217
PSIP1	hsa-miR-217-5p	92.2604	NM_001128217
PSIP1	hsa-miR-509-5p	92.2604	NM_001128217
PSIP1	hsa-miR-632	92.1438	NM_001128217
PSIP1	hsa-miR-4275	91.3349	NM_001128217
PSIP1	hsa-miR-4753-3p	91.2678	NM_021144
PSIP1	hsa-miR-3941	91.1503	NM_001128217
PSIP1	hsa-miR-548e-5p	90.8907	NM_001128217
PSIP1	hsa-miR-12132	90.4187	NM_001317898
PSIP1	hsa-miR-466	90.2985	NM_001128217
PSIP1	hsa-miR-548x-3p	89.7423	NM_001128217
PSIP1	hsa-miR-548aj-3p	89.7423	NM_001128217
PSIP1	hsa-miR-670-3p	89.6061	NM_001128217
PSIP1	hsa-miR-3664-3p	89.5603	NM_021144
PSIP1	hsa-miR-138-2-3p	89.1261	NM_001128217
PSIP1	hsa-miR-200b-3p	88.9027	NM_001128217
PSIP1	hsa-miR-429	88.9027	NM_001128217
PSIP1	hsa-miR-200c-3p	88.9027	NM_001128217
PSIP1	hsa-miR-6807-3p	88.6463	NM_001128217
PSIP1	hsa-miR-4418	88.6463	NM_001128217
PSIP1	hsa-miR-5582-3p	88.5326	NM_001128217
PSIP1	hsa-let-7b-3p	88.4397	NM_001128217
PSIP1	hsa-let-7f-1-3p	88.4397	NM_001128217
PSIP1	hsa-miR-98-3p	88.4397	NM_001128217
PSIP1	hsa-let-7a-3p	88.4397	NM_001128217
PSIP1	hsa-miR-1183	87.9738	NM_001317898
PSIP1	hsa-miR-548am-3p	87.6528	NM_001128217
PSIP1	hsa-miR-548j-3p	87.6528	NM_001128217
PSIP1	hsa-miR-548aq-3p	87.6528	NM_001128217
PSIP1	hsa-miR-548ae-3p	87.6528	NM_001128217
PSIP1	hsa-miR-548ah-3p	87.6528	NM_001128217
PSIP1	hsa-miR-450a-1-3p	87.5343	NM_001128217

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Motifs and transcription factors (TFs) regulating PSIP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PSIP1	metacluster_101.3	MYB (directAnnotation).
PSIP1	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
PSIP1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
PSIP1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
PSIP1	transfac_pro__M05706	ZNF20 (directAnnotation).
PSIP1	taipale_tf_pairs__HOXD12_ELK3_NTTTAYNNCCGGAARNN_CAP_repr	ELK3; HOXD12 (directAnnotation).
PSIP1	metacluster_72.1	ZNF423; ZNF423 (directAnnotation).
PSIP1	metacluster_155.33	ZNF16; ZNF816 (directAnnotation).
PSIP1	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
PSIP1	taipale_tf_pairs__FOXO1_ETV4_RWMAACAGGAARNN_CAP	ETV4; FOXO1 (directAnnotation).
PSIP1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PSIP1	transfac_pro__M04862	NRF1 (directAnnotation).
PSIP1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PSIP1	hdpi__ELF2	ELF2 (directAnnotation).
PSIP1	metacluster_81.7	CREB1 (directAnnotation).
PSIP1	transfac_pro__M06415	ZNF429 (directAnnotation).
PSIP1	hocomoco__E2F8_HUMAN.H11MO.0.D	E2F8 (directAnnotation).
PSIP1	transfac_pro__M06096	ZNF682 (directAnnotation).
PSIP1	homer__TACGTGCV_HIF-1a	HIF1A (directAnnotation).
PSIP1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
PSIP1	hdpi__NRL	NRL (directAnnotation).
PSIP1	transfac_pro__M07310	SP5 (directAnnotation).
PSIP1	cisbp__M00968	MTF2 (directAnnotation).
PSIP1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PSIP1	transfac_pro__M04817	ZBTB33 (directAnnotation).
PSIP1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
PSIP1	tfdimers__MD00483	ZBTB14 (directAnnotation).
PSIP1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PSIP1	transfac_pro__M07317	CTBP1 (directAnnotation).
PSIP1	transfac_pro__M12697	ZNF142 (directAnnotation).
PSIP1	transfac_pro__M00716	ZBTB14 (directAnnotation).
PSIP1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
PSIP1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
PSIP1	transfac_pro__M04893	TAF1 (directAnnotation).
PSIP1	transfac_pro__M01253	CNOT3 (directAnnotation).
PSIP1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
PSIP1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PSIP1	transfac_pro__M04916	TAF1 (directAnnotation).
PSIP1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
PSIP1	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
PSIP1	hdpi__RARA	RARA (directAnnotation).
PSIP1	hdpi__HTATIP2	HTATIP2 (directAnnotation).
PSIP1	jaspar__MA1650.1	ZBTB14 (directAnnotation).
PSIP1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PSIP1	hdpi__HIP2	UBE2K (directAnnotation).
PSIP1	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
PSIP1	hdpi__ZNF304	ZNF304 (directAnnotation).
PSIP1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
PSIP1	cisbp__M08228	PAX5 (directAnnotation).
PSIP1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."