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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PRKG1

Summary for PRKG1

Gene information	Gene symbol	PRKG1
	Ensembl ID	ENSG00000185532
	Entrez ID	5592
	Gene name	protein kinase cGMP-dependent 1
	Synonyms	PGK\|PKG\|PKG1\|PRKG1B\|PRKGR1B
	Gene type	protein_coding
	UniProtAcc	Q13976

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Dataset with differentially expressed gene: PRKG1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	3.1438	5.15e-06
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.412555	0.00e+00

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Expression of PRKG1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PRKG1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PRKG1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PRKG1	hsa-miR-195-3p	99.1796	NM_006258
PRKG1	hsa-miR-16-2-3p	99.1796	NM_006258
PRKG1	hsa-miR-6501-3p	98.7051	NM_001098512
PRKG1	hsa-miR-656-3p	98.2869	NM_006258
PRKG1	hsa-miR-3163	97.0021	NM_001098512
PRKG1	hsa-miR-6830-3p	96.9771	NM_001098512
PRKG1	hsa-miR-1305	96.6507	NM_006258
PRKG1	hsa-miR-543	96.0846	NM_001098512
PRKG1	hsa-miR-6507-5p	95.1178	NM_006258
PRKG1	hsa-miR-5680	95.1092	NM_001098512
PRKG1	hsa-miR-4294	94.959	NM_006258
PRKG1	hsa-miR-142-5p	94.7535	NM_006258
PRKG1	hsa-miR-5590-3p	94.7535	NM_006258
PRKG1	hsa-miR-3646	94.6804	NM_001098512
PRKG1	hsa-miR-29b-2-5p	94.6076	NM_001098512
PRKG1	hsa-miR-3662	94.3575	NM_006258
PRKG1	hsa-miR-570-3p	94.0621	NM_001098512
PRKG1	hsa-miR-203a-3p	93.1426	NM_001098512
PRKG1	hsa-miR-429	93.1036	NM_001098512
PRKG1	hsa-miR-200b-3p	93.1036	NM_001098512
PRKG1	hsa-miR-200c-3p	93.1036	NM_001098512
PRKG1	hsa-miR-3910	93.0178	NM_001098512
PRKG1	hsa-miR-448	92.7307	NM_001098512
PRKG1	hsa-miR-3686	92.6441	NM_001098512
PRKG1	hsa-miR-4652-3p	92.6378	NM_001098512
PRKG1	hsa-miR-103a-3p	92.4858	NM_001098512
PRKG1	hsa-miR-107	92.4858	NM_001098512
PRKG1	hsa-miR-548p	92.386	NM_006258
PRKG1	hsa-miR-888-3p	92.2042	NM_001098512
PRKG1	hsa-miR-4793-3p	91.9744	NM_001098512
PRKG1	hsa-miR-1252-3p	91.9259	NM_006258
PRKG1	hsa-miR-513c-3p	91.9229	NM_006258
PRKG1	hsa-miR-513a-3p	91.9229	NM_006258
PRKG1	hsa-miR-4494	91.3956	NM_006258
PRKG1	hsa-miR-218-5p	91.3234	NM_001098512
PRKG1	hsa-miR-5682	91.085	NM_001098512
PRKG1	hsa-miR-4775	90.5954	NM_006258
PRKG1	hsa-miR-513a-5p	90.4683	NM_001098512
PRKG1	hsa-miR-4680-5p	89.9689	NM_006258
PRKG1	hsa-miR-7109-3p	89.8995	NM_001098512
PRKG1	hsa-miR-12136	89.8108	NM_006258
PRKG1	hsa-miR-6831-3p	89.7226	NM_001098512
PRKG1	hsa-miR-3606-3p	89.6623	NM_006258
PRKG1	hsa-miR-7-2-3p	89.6235	NM_006258
PRKG1	hsa-miR-7-1-3p	89.6235	NM_006258
PRKG1	hsa-miR-9985	89.281	NM_001098512
PRKG1	hsa-miR-27b-3p	89.281	NM_001098512
PRKG1	hsa-miR-27a-3p	89.281	NM_001098512
PRKG1	hsa-miR-6509-5p	89.194	NM_006258
PRKG1	hsa-miR-335-3p	88.4633	NM_006258

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Motifs and transcription factors (TFs) regulating PRKG1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PRKG1	transfac_pro__M01175	ZBTB7B (directAnnotation).
PRKG1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
PRKG1	jaspar__MA1122.1	TFDP1 (directAnnotation).
PRKG1	transfac_pro__M07297	MAZ (directAnnotation).
PRKG1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
PRKG1	cisbp__M00968	MTF2 (directAnnotation).
PRKG1	metacluster_163.2	ZNF682 (directAnnotation).
PRKG1	transfac_pro__M04916	TAF1 (directAnnotation).
PRKG1	metacluster_170.1	ZNF460; ZNF460; ZNF468; ZNF468 (directAnnotation).
PRKG1	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
PRKG1	transfac_pro__M00938	E2F1 (directAnnotation).
PRKG1	transfac_pro__M02090	E2F4 (directAnnotation).
PRKG1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
PRKG1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
PRKG1	transfac_pro__M01303	SP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."