Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PRKAR1A

Summary for PRKAR1A

Gene information	Gene symbol	PRKAR1A
	Ensembl ID	ENSG00000108946
	Entrez ID	5573
	Gene name	protein kinase cAMP-dependent type I regulatory subunit alpha
	Synonyms	CNC1\|PRKAR1\|TSE1
	Gene type	protein_coding
	UniProtAcc	P10644

Top

Dataset with differentially expressed gene: PRKAR1A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.430592	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.261953	8.36e-06
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.498948	3.05e-07
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.341831	1.12e-11
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.334127	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.470366	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.630862	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.575498	0.00e+00

Top

Expression of PRKAR1A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to PRKAR1A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating PRKAR1A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PRKAR1A	hsa-miR-548x-3p	96.1345	NM_001276289
PRKAR1A	hsa-miR-548aj-3p	96.1345	NM_001276289
PRKAR1A	hsa-miR-494-3p	96.0645	NM_001276290
PRKAR1A	hsa-miR-4701-5p	95.4981	NM_001276289
PRKAR1A	hsa-miR-588	95.4981	NM_001276289
PRKAR1A	hsa-miR-4422	95.3497	NM_001276289
PRKAR1A	hsa-miR-548ah-3p	95.025	NM_001276289
PRKAR1A	hsa-miR-548ae-3p	95.025	NM_001276289
PRKAR1A	hsa-miR-548aq-3p	95.025	NM_001276289
PRKAR1A	hsa-miR-548am-3p	95.025	NM_001276289
PRKAR1A	hsa-miR-548j-3p	95.025	NM_001276289
PRKAR1A	hsa-miR-3658	94.6504	NM_001276289
PRKAR1A	hsa-miR-6830-3p	93.7485	NM_001276289
PRKAR1A	hsa-miR-96-5p	92.1006	NM_001276289
PRKAR1A	hsa-miR-5011-5p	91.223	NM_001276289
PRKAR1A	hsa-miR-3120-3p	91.1491	NM_001276289
PRKAR1A	hsa-miR-1271-5p	90.9221	NM_001276289
PRKAR1A	hsa-miR-12133	90.9221	NM_001276289
PRKAR1A	hsa-miR-6505-5p	90.7754	NM_001276289
PRKAR1A	hsa-miR-6508-5p	90.4865	NM_001276289
PRKAR1A	hsa-miR-190a-3p	89.9013	NM_001276289
PRKAR1A	hsa-miR-875-3p	89.6854	NM_001276289
PRKAR1A	hsa-miR-1468-3p	89.3392	NM_001276289
PRKAR1A	hsa-miR-519d-5p	89.1106	NM_001276289
PRKAR1A	hsa-miR-653-3p	88.3985	NM_001276289
PRKAR1A	hsa-miR-5688	87.8988	NM_001276289
PRKAR1A	hsa-miR-548e-5p	87.7646	NM_001276289
PRKAR1A	hsa-miR-5584-5p	87.7108	NM_001276289
PRKAR1A	hsa-miR-7-1-3p	87.6949	NM_001276289
PRKAR1A	hsa-miR-7-2-3p	87.6949	NM_001276289
PRKAR1A	hsa-miR-495-3p	87.6949	NM_001276289
PRKAR1A	hsa-miR-5696	87.6439	NM_001276289
PRKAR1A	hsa-miR-9-3p	87.2474	NM_001276289
PRKAR1A	hsa-miR-7844-5p	86.739	NM_001276289
PRKAR1A	hsa-miR-4482-3p	86.5582	NM_001276289
PRKAR1A	hsa-miR-6835-3p	86.4537	NM_001276289
PRKAR1A	hsa-miR-483-3p	86.3157	NM_001276289
PRKAR1A	hsa-miR-514a-5p	85.4887	NM_001276289
PRKAR1A	hsa-miR-3148	85.1074	NM_001276289
PRKAR1A	hsa-miR-4432	84.8567	NM_001276289
PRKAR1A	hsa-miR-499a-5p	84.7177	NM_001276289
PRKAR1A	hsa-miR-561-3p	84.4107	NM_001276289
PRKAR1A	hsa-miR-518c-5p	84.3892	NM_001276289
PRKAR1A	hsa-miR-150-5p	84.3508	NM_001276289
PRKAR1A	hsa-miR-548az-3p	83.2766	NM_001276289
PRKAR1A	hsa-miR-548p	83.1905	NM_001276289
PRKAR1A	hsa-miR-7159-3p	82.8012	NM_001276289
PRKAR1A	hsa-miR-1256	82.0548	NM_001276289
PRKAR1A	hsa-miR-585-5p	81.6503	NM_001276289
PRKAR1A	hsa-miR-1236-5p	81.1425	NM_001276290

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating PRKAR1A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PRKAR1A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PRKAR1A	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
PRKAR1A	transfac_pro__M02898	SMAD3 (directAnnotation).
PRKAR1A	transfac_public__M00491	PATZ1 (directAnnotation).
PRKAR1A	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
PRKAR1A	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
PRKAR1A	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
PRKAR1A	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
PRKAR1A	metacluster_135.11	NR2C2 (directAnnotation).
PRKAR1A	cisbp__M00968	MTF2 (directAnnotation).
PRKAR1A	cisbp__M00341	PAX6 (directAnnotation).
PRKAR1A	metacluster_198.3	ZFP64 (directAnnotation).
PRKAR1A	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PRKAR1A	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PRKAR1A	cisbp__M00788	ZFY (inferredBy_Orthology).
PRKAR1A	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
PRKAR1A	metacluster_175.1	ZNF283 (directAnnotation).
PRKAR1A	hdpi__ZNF304	ZNF304 (directAnnotation).
PRKAR1A	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
PRKAR1A	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PRKAR1A	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PRKAR1A	transfac_pro__M01199	TRIM28 (directAnnotation).
PRKAR1A	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
PRKAR1A	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PRKAR1A	transfac_pro__M03806	ZBTB7C (directAnnotation).
PRKAR1A	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PRKAR1A	transfac_pro__M06404	ZNF497 (directAnnotation).
PRKAR1A	tfdimers__MD00047	NR3C1; PGR; ZFP42 (directAnnotation).
PRKAR1A	jaspar__MA1105.2	GRHL2 (directAnnotation).
PRKAR1A	tfdimers__MD00032	GFI1; GFI1B; NKX3-2 (directAnnotation).
PRKAR1A	hocomoco__KAISO_HUMAN.H11MO.2.A	ZBTB33 (directAnnotation).
PRKAR1A	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
PRKAR1A	metacluster_155.28	ZFP64 (directAnnotation). ZFP64 (inferredBy_Orthology).
PRKAR1A	tfdimers__MD00557	MZF1 (directAnnotation).
PRKAR1A	tfdimers__MD00376	HOXA13; KLF4 (directAnnotation).
PRKAR1A	metacluster_130.16	ZNF705A (directAnnotation).
PRKAR1A	metacluster_136.3	MAX; MXI1; MXI1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX4; RFX4; RFX4; RFX4; RFX5; RFX5; RFX5; SREBF1; ZBTB7B (directAnnotation). RFX1; RFX1; RFX1; RFX1; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX3; RFX3; RFX3; RFX3; RFX3; RFX4; RFX4; RFX4; RFX6; RFX6; RFX6; RFX7; RFX8; RFX8 (inferredBy_Orthology).
PRKAR1A	taipale_tf_pairs__ETV2_NHLH1_NCCGGAANNNNNNCAGCTGNN_CAP_repr	ETV2; NHLH1 (directAnnotation).
PRKAR1A	taipale_tf_pairs__GCM1_FOXI1_NTGTTGATRNGGGN_CAP_repr	FOXI1; GCM1 (directAnnotation).
PRKAR1A	jaspar__MA1946.1	FOXI1 (directAnnotation).
PRKAR1A	tfdimers__MD00221	FOXG1; FOXO1; GABPA (directAnnotation).
PRKAR1A	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
PRKAR1A	jaspar__MA1955.1	FOXO1 (directAnnotation).
PRKAR1A	transfac_pro__M05785	ZNF48 (inferredBy_Orthology).
PRKAR1A	transfac_pro__M12697	ZNF142 (directAnnotation).
PRKAR1A	transfac_pro__M06173	ZNF85 (directAnnotation).
PRKAR1A	jaspar__MA1650.1	ZBTB14 (directAnnotation).
PRKAR1A	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PRKAR1A	tfdimers__MD00483	ZBTB14 (directAnnotation).
PRKAR1A	tfdimers__MD00364	WT1 (directAnnotation).

Page: 1 2 3

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PRKAR1A	"(Rp)-cAMPS"	DB01790	small molecule
PRKAR1A	"Cyclic adenosine monophosphate"	DB02527	small molecule
PRKAR1A	"Cyclic GMP"	DB02315	small molecule
PRKAR1A	"GEM-231"	DB05798	biotech

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."