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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PRKAG2

Summary for PRKAG2

Gene information	Gene symbol	PRKAG2
	Ensembl ID	ENSG00000106617
	Entrez ID	51422
	Gene name	protein kinase AMP-activated non-catalytic subunit gamma 2
	Synonyms	AAKG\|AAKG2\|CMH6\|H91620p\|WPWS
	Gene type	protein_coding
	UniProtAcc	Q9UGJ0

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Dataset with differentially expressed gene: PRKAG2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.364862	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.546206	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.334543	3.66e-24
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.378051	1.00e-24
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.377624	0.00e+00

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Expression of PRKAG2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PRKAG2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PRKAG2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PRKAG2	hsa-miR-653-3p	96.2295	NM_001040633
PRKAG2	hsa-miR-3646	96.086	NM_001040633
PRKAG2	hsa-miR-506-3p	93.295	NM_001040633
PRKAG2	hsa-miR-203a-3p	93.0412	NM_001040633
PRKAG2	hsa-miR-5011-5p	92.3801	NM_001304531
PRKAG2	hsa-miR-124-3p	92.1741	NM_001040633
PRKAG2	hsa-miR-4801	90.4528	NM_001304531
PRKAG2	hsa-miR-4731-3p	89.9839	NM_001304531
PRKAG2	hsa-miR-4279	88.3399	NM_001040633
PRKAG2	hsa-miR-6501-3p	88.2432	NM_001040633
PRKAG2	hsa-miR-5688	87.9943	NM_001304531
PRKAG2	hsa-miR-6515-3p	87.9235	NM_001304531
PRKAG2	hsa-miR-3120-3p	87.8387	NM_001040633
PRKAG2	hsa-miR-7156-3p	87.2044	NM_001304531
PRKAG2	hsa-miR-5002-5p	86.6226	NM_001040633
PRKAG2	hsa-miR-559	85.9386	NM_001304531
PRKAG2	hsa-miR-4262	84.955	NM_001040633
PRKAG2	hsa-miR-4293	84.8037	NM_001040633
PRKAG2	hsa-miR-190a-3p	84.7918	NM_001304531
PRKAG2	hsa-miR-495-3p	84.5002	NM_001304531
PRKAG2	hsa-miR-148a-3p	84.1776	NM_001040633
PRKAG2	hsa-miR-148b-3p	84.1776	NM_001040633
PRKAG2	hsa-miR-152-3p	84.1776	NM_001040633
PRKAG2	hsa-miR-548o-5p	83.666	NM_001304531
PRKAG2	hsa-miR-548c-5p	83.666	NM_001304531
PRKAG2	hsa-miR-548d-5p	83.666	NM_001304531
PRKAG2	hsa-miR-548j-5p	83.666	NM_001304531
PRKAG2	hsa-miR-548bb-5p	83.666	NM_001304531
PRKAG2	hsa-miR-548i	83.666	NM_001304531
PRKAG2	hsa-miR-548ad-5p	83.666	NM_001304531
PRKAG2	hsa-miR-548ay-5p	83.666	NM_001304531
PRKAG2	hsa-miR-548ak	83.666	NM_001304531
PRKAG2	hsa-miR-548w	83.666	NM_001304531
PRKAG2	hsa-miR-548b-5p	83.666	NM_001304531
PRKAG2	hsa-miR-548a-5p	83.666	NM_001304531
PRKAG2	hsa-miR-548ar-5p	83.666	NM_001304531
PRKAG2	hsa-miR-548ab	83.666	NM_001304531
PRKAG2	hsa-miR-548am-5p	83.666	NM_001304531
PRKAG2	hsa-miR-548h-5p	83.666	NM_001304531
PRKAG2	hsa-miR-548as-5p	83.666	NM_001304531
PRKAG2	hsa-miR-548au-5p	83.666	NM_001304531
PRKAG2	hsa-miR-548ae-5p	83.666	NM_001304531
PRKAG2	hsa-miR-548y	83.666	NM_001304531
PRKAG2	hsa-miR-548ap-5p	83.666	NM_001304531
PRKAG2	hsa-miR-1206	83.4548	NM_001304531
PRKAG2	hsa-miR-505-3p	83.4394	NM_001304531
PRKAG2	hsa-miR-4762-5p	83.2552	NM_001304531
PRKAG2	hsa-miR-1827	83.2114	NM_001040633
PRKAG2	hsa-miR-181c-5p	81.2759	NM_001040633
PRKAG2	hsa-miR-498-5p	81.2082	NM_001040633

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Motifs and transcription factors (TFs) regulating PRKAG2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PRKAG2	transfac_pro__M01973	PLAG1 (directAnnotation).
PRKAG2	tfdimers__MD00483	ZBTB14 (directAnnotation).
PRKAG2	metacluster_198.3	ZFP64 (directAnnotation).
PRKAG2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PRKAG2	transfac_pro__M01303	SP1 (directAnnotation).
PRKAG2	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
PRKAG2	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
PRKAG2	transfac_pro__M07387	ZBTB7A (directAnnotation).
PRKAG2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PRKAG2	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
PRKAG2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PRKAG2	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
PRKAG2	transfac_pro__M07329	SP7 (directAnnotation).
PRKAG2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PRKAG2	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
PRKAG2	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
PRKAG2	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
PRKAG2	hdpi__FLI1	FLI1 (directAnnotation).
PRKAG2	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
PRKAG2	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
PRKAG2	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
PRKAG2	cisbp__M08198	ELF1 (directAnnotation).
PRKAG2	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
PRKAG2	metacluster_81.7	CREB1 (directAnnotation).
PRKAG2	transfac_pro__M00492	STAT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."