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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PRDM2

Summary for PRDM2

Gene information	Gene symbol	PRDM2
	Ensembl ID	ENSG00000116731
	Entrez ID	7799
	Gene name	PR/SET domain 2
	Synonyms	HUMHOXY1\|KMT8\|KMT8A\|MTB-ZF\|RIZ\|RIZ1\|RIZ2
	Gene type	protein_coding
	UniProtAcc	Q13029

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Dataset with differentially expressed gene: PRDM2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.615384	4.32e-27
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.548358	5.37e-29
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.329775	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.319053	1.05e-37
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.318632	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.354236	4.11e-41
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.286585	0.00e+00

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Expression of PRDM2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PRDM2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PRDM2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PRDM2	hsa-miR-3529-3p	95.3627	NM_001007257
PRDM2	hsa-miR-7976	95.3011	NM_012231
PRDM2	hsa-miR-5582-3p	95.2718	NM_012231
PRDM2	hsa-miR-204-5p	94.4239	NM_012231
PRDM2	hsa-miR-211-5p	94.4239	NM_012231
PRDM2	hsa-miR-6716-5p	93.9907	NM_001007257
PRDM2	hsa-miR-196a-1-3p	93.6429	NM_001007257
PRDM2	hsa-miR-7110-3p	93.2897	NM_001007257
PRDM2	hsa-miR-153-3p	92.892	NM_012231
PRDM2	hsa-miR-6779-3p	92.4666	NM_012231
PRDM2	hsa-miR-3065-5p	92.0658	NM_001007257
PRDM2	hsa-miR-4796-5p	90.4096	NM_001007257
PRDM2	hsa-miR-548aw	90.401	NM_012231
PRDM2	hsa-miR-216b-5p	90.387	NM_001007257
PRDM2	hsa-miR-5195-3p	89.9384	NM_012231
PRDM2	hsa-miR-145-5p	89.9384	NM_012231
PRDM2	hsa-miR-211-3p	89.416	NM_012231
PRDM2	hsa-miR-1913	89.3519	NM_012231
PRDM2	hsa-miR-6854-5p	88.6713	NM_012231
PRDM2	hsa-miR-6738-3p	86.6682	NM_012231
PRDM2	hsa-miR-5692c	86.5266	NM_001007257
PRDM2	hsa-miR-5692b	86.5266	NM_001007257
PRDM2	hsa-miR-6873-3p	85.7032	NM_001007257
PRDM2	hsa-miR-448	85.5536	NM_012231
PRDM2	hsa-miR-519d-5p	85.2128	NM_001007257
PRDM2	hsa-miR-3613-3p	84.5223	NM_001007257
PRDM2	hsa-miR-590-3p	84.38	NM_001007257
PRDM2	hsa-miR-1251-3p	84.3155	NM_001007257
PRDM2	hsa-miR-4666a-3p	83.8568	NM_001007257
PRDM2	hsa-miR-345-3p	83.6607	NM_012231
PRDM2	hsa-miR-6766-5p	83.3805	NM_012231
PRDM2	hsa-miR-6756-5p	83.3805	NM_012231
PRDM2	hsa-miR-5589-3p	82.9488	NM_012231
PRDM2	hsa-miR-216b-3p	82.9035	NM_001135610
PRDM2	hsa-miR-5692a	82.0162	NM_001007257
PRDM2	hsa-miR-6817-3p	81.0383	NM_001007257
PRDM2	hsa-miR-374c-5p	80.9427	NM_001007257
PRDM2	hsa-miR-655-3p	80.9427	NM_001007257
PRDM2	hsa-let-7b-3p	80.8657	NM_001007257
PRDM2	hsa-let-7f-1-3p	80.8657	NM_001007257
PRDM2	hsa-let-7a-3p	80.8657	NM_001007257
PRDM2	hsa-miR-98-3p	80.8657	NM_001007257
PRDM2	hsa-miR-4533	80.5883	NM_001007257

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Motifs and transcription factors (TFs) regulating PRDM2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PRDM2	hdpi__RARA	RARA (directAnnotation).
PRDM2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PRDM2	hdpi__ELF2	ELF2 (directAnnotation).
PRDM2	taipale_tf_pairs__TFAP2C_DLX3_NSCCNNNRGGCANNNNNNTAATKR_CAP_repr	DLX3; TFAP2C (directAnnotation).
PRDM2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PRDM2	jaspar__MA1583.1	ZFP57 (directAnnotation).
PRDM2	transfac_pro__M02898	SMAD3 (directAnnotation).
PRDM2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PRDM2	hdpi__HTATIP2	HTATIP2 (directAnnotation).
PRDM2	jaspar__MA1721.1	ZNF93 (directAnnotation).
PRDM2	transfac_pro__M04916	TAF1 (directAnnotation).
PRDM2	jaspar__MA1122.1	TFDP1 (directAnnotation).
PRDM2	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
PRDM2	transfac_pro__M07310	SP5 (directAnnotation).
PRDM2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
PRDM2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PRDM2	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
PRDM2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PRDM2	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
PRDM2	cisbp__M00249	WT1 (directAnnotation).
PRDM2	metacluster_182.10	ZFX (directAnnotation).
PRDM2	hdpi__ZNF304	ZNF304 (directAnnotation).
PRDM2	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
PRDM2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
PRDM2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PRDM2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PRDM2	metacluster_151.2	ZNF23 (directAnnotation).
PRDM2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PRDM2	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
PRDM2	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
PRDM2	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
PRDM2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
PRDM2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
PRDM2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PRDM2	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
PRDM2	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
PRDM2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PRDM2	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
PRDM2	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
PRDM2	transfac_pro__M12697	ZNF142 (directAnnotation).
PRDM2	metacluster_175.1	ZNF283 (directAnnotation).
PRDM2	tfdimers__MD00364	WT1 (directAnnotation).
PRDM2	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
PRDM2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PRDM2	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
PRDM2	transfac_pro__M01973	PLAG1 (directAnnotation).
PRDM2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
PRDM2	tfdimers__MD00483	ZBTB14 (directAnnotation).
PRDM2	metacluster_198.3	ZFP64 (directAnnotation).
PRDM2	transfac_pro__M01303	SP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."