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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: PRDM1

Summary for PRDM1

Gene information	Gene symbol	PRDM1
	Ensembl ID	ENSG00000057657
	Entrez ID	639
	Gene name	PR/SET domain 1
	Synonyms	BLIMP1\|PRDI-BF1
	Gene type	protein_coding
	UniProtAcc	O75626

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Dataset with differentially expressed gene: PRDM1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.412279	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Plasma cells	0.43191	2.65e-23
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.386065	1.29e-20
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.527757	2.17e-41
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.665163	9.62e-36
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.726858	6.44e-36
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	NK cells	0.290128	3.31e-41
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.739389	6.36e-22
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.540044	5.22e-31
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.2568	3.50e-30
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.330202	0.00e+00

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Expression of PRDM1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PRDM1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PRDM1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PRDM1	hsa-miR-5011-5p	100	NM_001198
PRDM1	hsa-miR-190a-3p	99.9998	NM_001198
PRDM1	hsa-miR-5692a	99.535	NM_001198
PRDM1	hsa-miR-30e-5p	99.2136	NM_001198
PRDM1	hsa-miR-30d-5p	99.2136	NM_001198
PRDM1	hsa-miR-30a-5p	99.2136	NM_001198
PRDM1	hsa-miR-30b-5p	99.2136	NM_001198
PRDM1	hsa-miR-30c-5p	99.2136	NM_001198
PRDM1	hsa-miR-4328	98.4375	NM_001198
PRDM1	hsa-miR-9-5p	98.0543	NM_001198
PRDM1	hsa-miR-23c	97.4422	NM_001198
PRDM1	hsa-miR-23b-3p	97.4422	NM_001198
PRDM1	hsa-miR-23a-3p	97.4422	NM_001198
PRDM1	hsa-miR-133a-3p	97.3519	NM_001198
PRDM1	hsa-miR-133b	97.3519	NM_001198
PRDM1	hsa-miR-340-5p	97.0464	NM_001198
PRDM1	hsa-miR-5692b	96.7154	NM_001198
PRDM1	hsa-miR-5692c	96.7154	NM_001198
PRDM1	hsa-miR-140-5p	95.8271	NM_001198
PRDM1	hsa-miR-369-3p	95.1297	NM_001198
PRDM1	hsa-miR-874-3p	95.0163	NM_001198
PRDM1	hsa-miR-3671	94.6502	NM_001198
PRDM1	hsa-miR-944	94.5343	NM_001198
PRDM1	hsa-miR-4284	94.4779	NM_001198
PRDM1	hsa-miR-4729	94.1447	NM_001198
PRDM1	hsa-miR-1250-3p	93.6266	NM_001198
PRDM1	hsa-miR-4662a-3p	93.4514	NM_001198
PRDM1	hsa-miR-145-5p	93.416	NM_001198
PRDM1	hsa-miR-5195-3p	93.416	NM_001198
PRDM1	hsa-miR-7976	93.3493	NM_001198
PRDM1	hsa-miR-497-3p	93.1244	NM_001198
PRDM1	hsa-miR-4319	92.2464	NM_001198
PRDM1	hsa-miR-125b-5p	92.0745	NM_001198
PRDM1	hsa-miR-125a-5p	92.0745	NM_001198
PRDM1	hsa-miR-557	92.0452	NM_001198
PRDM1	hsa-miR-507	92.0452	NM_001198
PRDM1	hsa-miR-4659a-3p	91.9216	NM_001198
PRDM1	hsa-miR-4659b-3p	91.9216	NM_001198
PRDM1	hsa-miR-548ap-3p	91.7811	NM_001198
PRDM1	hsa-miR-548t-3p	91.7811	NM_001198
PRDM1	hsa-miR-548aa	91.7811	NM_001198
PRDM1	hsa-miR-1251-3p	91.4143	NM_001198
PRDM1	hsa-miR-5580-3p	91.0546	NM_001198
PRDM1	hsa-miR-374b-5p	90.8982	NM_001198
PRDM1	hsa-miR-374a-5p	90.8982	NM_001198
PRDM1	hsa-miR-6859-5p	90.691	NM_001198
PRDM1	hsa-miR-3916	90.691	NM_001198
PRDM1	hsa-miR-4719	90.6	NM_001198
PRDM1	hsa-miR-888-5p	90.5228	NM_001198
PRDM1	hsa-miR-3924	89.3497	NM_001198

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Motifs and transcription factors (TFs) regulating PRDM1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PRDM1	hdpi__ETS1	ETS1 (directAnnotation).
PRDM1	metacluster_97.2	GTF3A (inferredBy_Orthology).
PRDM1	jaspar__MA0100.3	MYB (directAnnotation).
PRDM1	transfac_pro__M05779	ZNF674 (directAnnotation).
PRDM1	transfac_pro__M05534	PRDM14 (directAnnotation).
PRDM1	metacluster_134.1	ZFP69 (directAnnotation).
PRDM1	transfac_pro__M06405	ZNF329 (directAnnotation).
PRDM1	metacluster_46.5	HLF; TEF (directAnnotation).
PRDM1	transfac_pro__M05690	ZNF20 (directAnnotation).
PRDM1	transfac_pro__M06646	ZNF607 (directAnnotation).
PRDM1	taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP	ETV2; SPDEF (directAnnotation).
PRDM1	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
PRDM1	metacluster_172.10	ZNF18; ZNF417; ZNF587 (directAnnotation).
PRDM1	kznf__YY1_Transfac.5_Transfac	YY1 (directAnnotation).
PRDM1	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
PRDM1	transfac_pro__M05410	ZSCAN1 (directAnnotation).
PRDM1	hdpi__MECP2	MECP2 (directAnnotation).
PRDM1	transfac_pro__M06314	ZNF239 (directAnnotation).
PRDM1	hdpi__SCMH1	SCMH1 (directAnnotation).
PRDM1	taipale_tf_pairs__PITX1_TBX21_AGGTGNGAARGGATTA_CAP_repr	PITX1; TBX21 (directAnnotation).
PRDM1	metacluster_187.3	SPDEF; SPDEF (directAnnotation).
PRDM1	taipale_tf_pairs__ELK1_SPDEF_NSMGGACGGAYNTCCKSN_CAP	ELK1; SPDEF (directAnnotation).
PRDM1	metacluster_84.12	RARB; RARG (directAnnotation).
PRDM1	hocomoco__NR4A1_MOUSE.H11MO.0.B	NR4A1 (inferredBy_Orthology).
PRDM1	transfac_pro__M06370	ZNF585A (directAnnotation).
PRDM1	metacluster_161.2	LHX8 (directAnnotation).
PRDM1	taipale_tf_pairs__ETV2_NHLH1_NGCAGCTGCCGGAWRYN_CAP_repr	ETV2; NHLH1 (directAnnotation).
PRDM1	transfac_pro__M05422	FOXD4L4 (directAnnotation).
PRDM1	tfdimers__MD00147	ELF5; TFAP2C (directAnnotation).
PRDM1	taipale_tf_pairs__ELK1_ETV7_NNSMGGACGGAYNTCCKSNN_CAP	ELK1; ETV7 (directAnnotation).
PRDM1	swissregulon__hs__SOX9	SOX9 (directAnnotation).
PRDM1	transfac_pro__M07448	ZBED1 (directAnnotation).
PRDM1	hdpi__RAB18	RAB18 (directAnnotation).
PRDM1	homer__VVRRAACAATGG_Sox7	SOX7 (inferredBy_Orthology).
PRDM1	taipale_cyt_meth__JUND_NRTGACGCATN_eDBD_repr	JUND (directAnnotation).
PRDM1	transfac_pro__M05393	ZBTB6 (inferredBy_Orthology).
PRDM1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
PRDM1	transfac_pro__M00655	ETV4 (directAnnotation).
PRDM1	transfac_pro__M03844	ELK4 (directAnnotation).
PRDM1	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
PRDM1	transfac_pro__M05939	ZNF471 (directAnnotation).
PRDM1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
PRDM1	swissregulon__hs__ELF2	ELF2 (directAnnotation).
PRDM1	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
PRDM1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
PRDM1	metacluster_187.2	PRDM1; PRDM1; ZNF184 (directAnnotation).
PRDM1	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
PRDM1	metacluster_2.7	up	Malignant cells	GSE161801_PI	post
PRDM1	metacluster_2.9	up	Malignant cells	GSE161801_PI	post
PRDM1	metacluster_2.9	up	Malignant cells	GSE161801_PI	pre
PRDM1	metacluster_2.9	up	CD8+ T cells	GSE207422_Sin	post
PRDM1	metacluster_187.2	up	CD4+ T cells	PMID34715028	post

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."