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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PPP4R1

Summary for PPP4R1

Gene information	Gene symbol	PPP4R1
	Ensembl ID	ENSG00000154845
	Entrez ID	9989
	Gene name	protein phosphatase 4 regulatory subunit 1
	Synonyms	PP4R1
	Gene type	protein_coding
	UniProtAcc	Q8TF05

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Dataset with differentially expressed gene: PPP4R1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.358918	6.47e-21
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.33718	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.347319	1.06e-27
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.251385	0.00e+00

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Expression of PPP4R1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPP4R1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPP4R1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPP4R1	hsa-let-7g-3p	97.5196	NM_001042388
PPP4R1	hsa-let-7a-2-3p	97.5196	NM_001042388
PPP4R1	hsa-miR-7161-3p	96.1958	NM_005134
PPP4R1	hsa-miR-7-5p	95.7281	NM_001042388
PPP4R1	hsa-miR-3686	95.1166	NM_005134
PPP4R1	hsa-miR-500a-3p	94.5386	NM_005134
PPP4R1	hsa-miR-6804-3p	94.3076	NM_001042388
PPP4R1	hsa-miR-6508-5p	93.9572	NM_001042388
PPP4R1	hsa-miR-6780a-3p	93.8937	NM_001042388
PPP4R1	hsa-miR-8067	92.5461	NM_001042388
PPP4R1	hsa-miR-520e-5p	91.8815	NM_001042388
PPP4R1	hsa-miR-3921	91.4007	NM_001042388
PPP4R1	hsa-miR-4653-5p	91.4007	NM_001042388
PPP4R1	hsa-miR-26b-5p	91.006	NM_001042388
PPP4R1	hsa-miR-1297	91.006	NM_001042388
PPP4R1	hsa-miR-4446-3p	90.9722	NM_005134
PPP4R1	hsa-miR-500a-5p	90.9304	NM_001042388
PPP4R1	hsa-miR-570-3p	90.3432	NM_001042388
PPP4R1	hsa-miR-4286	90.1465	NM_005134
PPP4R1	hsa-miR-4520-2-3p	89.7417	NM_005134
PPP4R1	hsa-miR-634	89.6304	NM_001042388
PPP4R1	hsa-miR-26a-5p	89.2957	NM_001042388
PPP4R1	hsa-miR-7110-3p	87.9974	NM_005134
PPP4R1	hsa-miR-4251	87.4272	NM_001042388
PPP4R1	hsa-miR-6783-3p	87.1236	NM_005134
PPP4R1	hsa-miR-3194-3p	86.4451	NM_005134
PPP4R1	hsa-miR-8085	85.9457	NM_005134
PPP4R1	hsa-miR-6731-5p	85.9457	NM_005134
PPP4R1	hsa-miR-4465	85.9167	NM_001042388
PPP4R1	hsa-miR-4768-3p	85.7672	NM_001042388
PPP4R1	hsa-miR-1343-3p	85.6375	NM_005134
PPP4R1	hsa-miR-873-5p	85.4589	NM_001042388
PPP4R1	hsa-miR-548ap-3p	85.3988	NM_005134
PPP4R1	hsa-miR-548aa	85.3988	NM_005134
PPP4R1	hsa-miR-548t-3p	85.3988	NM_005134
PPP4R1	hsa-miR-338-3p	85.3773	NM_001042388
PPP4R1	hsa-miR-330-5p	85.0398	NM_001042388
PPP4R1	hsa-miR-9900	84.4362	NM_005134
PPP4R1	hsa-miR-379-5p	83.9032	NM_005134
PPP4R1	hsa-miR-3120-3p	83.1047	NM_001042388
PPP4R1	hsa-miR-3529-5p	82.8579	NM_005134
PPP4R1	hsa-miR-326	82.4271	NM_001042388
PPP4R1	hsa-miR-6886-5p	81.6224	NM_005134
PPP4R1	hsa-miR-6507-3p	81.125	NM_001042388
PPP4R1	hsa-miR-10397-3p	81.0484	NM_005134

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Motifs and transcription factors (TFs) regulating PPP4R1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPP4R1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
PPP4R1	hdpi__TP73	TP73 (directAnnotation).
PPP4R1	cisbp__M02645	ETS1 (directAnnotation).
PPP4R1	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
PPP4R1	metacluster_141.2	E2F2; E2F3 (directAnnotation).
PPP4R1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
PPP4R1	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
PPP4R1	transfac_pro__M04794	TAF1 (directAnnotation).
PPP4R1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
PPP4R1	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
PPP4R1	jaspar__MA0748.2	YY2 (directAnnotation).
PPP4R1	transfac_pro__M01298	MECP2 (directAnnotation).
PPP4R1	metacluster_182.10	ZFX (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."