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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PPP2R5A

Summary for PPP2R5A

Gene information	Gene symbol	PPP2R5A
	Ensembl ID	ENSG00000066027
	Entrez ID	5525
	Gene name	protein phosphatase 2 regulatory subunit B'alpha
	Synonyms	B56A\|B56alpha\|PR61A
	Gene type	protein_coding
	UniProtAcc	Q15172

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Dataset with differentially expressed gene: PPP2R5A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.273582	7.02e-13
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.266234	1.40e-11
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.431533	1.79e-09
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.278697	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.320907	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.853229	0.00e+00

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Expression of PPP2R5A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPP2R5A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
PPP2R5A	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating PPP2R5A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPP2R5A	hsa-miR-6835-3p	96.9461	NM_001199756
PPP2R5A	hsa-miR-218-5p	94.9514	NM_001199756
PPP2R5A	hsa-miR-224-5p	93.1158	NM_001199756
PPP2R5A	hsa-miR-4755-3p	90.2755	NM_001199756
PPP2R5A	hsa-miR-2276-3p	86.9069	NM_006243
PPP2R5A	hsa-miR-656-3p	86.1247	NM_006243
PPP2R5A	hsa-miR-299-5p	85.9465	NM_001199756
PPP2R5A	hsa-miR-2467-3p	85.9279	NM_006243
PPP2R5A	hsa-miR-4528	85.3881	NM_006243
PPP2R5A	hsa-miR-4464	85.187	NM_001199756
PPP2R5A	hsa-miR-3692-3p	85.102	NM_006243
PPP2R5A	hsa-miR-5579-5p	84.6597	NM_001199756
PPP2R5A	hsa-miR-1304-3p	83.8541	NM_001199756
PPP2R5A	hsa-miR-4790-3p	83.6714	NM_001199756
PPP2R5A	hsa-miR-10522-5p	83.4451	NM_006243
PPP2R5A	hsa-miR-548e-5p	83.2938	NM_001199756
PPP2R5A	hsa-miR-2113	83.191	NM_006243
PPP2R5A	hsa-miR-338-5p	83.0604	NM_001199756
PPP2R5A	hsa-miR-4540	82.5646	NM_001199756
PPP2R5A	hsa-miR-4748	81.1919	NM_001199756
PPP2R5A	hsa-miR-4502	80.5741	NM_001199756

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Motifs and transcription factors (TFs) regulating PPP2R5A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPP2R5A	jaspar__MA1650.1	ZBTB14 (directAnnotation).
PPP2R5A	transfac_pro__M02089	E2F3 (directAnnotation).
PPP2R5A	transfac_pro__M03806	ZBTB7C (directAnnotation).
PPP2R5A	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PPP2R5A	tfdimers__MD00483	ZBTB14 (directAnnotation).
PPP2R5A	tfdimers__MD00364	WT1 (directAnnotation).
PPP2R5A	transfac_pro__M04817	ZBTB33 (directAnnotation).
PPP2R5A	transfac_public__M00114	CREB1 (directAnnotation).
PPP2R5A	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
PPP2R5A	transfac_pro__M01253	CNOT3 (directAnnotation).
PPP2R5A	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
PPP2R5A	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."