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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PPP1R14B

Summary for PPP1R14B

Gene information	Gene symbol	PPP1R14B
	Ensembl ID	ENSG00000173457
	Entrez ID	26472
	Gene name	protein phosphatase 1 regulatory inhibitor subunit 14B
	Synonyms	PHI-1\|PLCB3N\|PNG\|SOM172
	Gene type	protein_coding
	UniProtAcc	Q96C90

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Dataset with differentially expressed gene: PPP1R14B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	1.55599	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	-0.497037	3.85e-02
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	cDCs	-0.316292	1.97e-03
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	pDCs	1.17337	5.89e-04
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.336431	2.69e-02
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD4+ T cells	0.2799	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	pDCs	-0.854601	1.94e-02
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	B cells	-0.558861	7.89e-03
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.52175	0.00e+00
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	-0.364009	4.95e-36
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	pDCs	-0.982938	2.85e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.802016	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.724436	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-1.02479	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.66223	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.610765	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.587973	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.613216	0.00e+00

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Expression of PPP1R14B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPP1R14B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPP1R14B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPP1R14B	hsa-miR-6771-3p	93.8549	NM_138689
PPP1R14B	hsa-miR-6885-5p	86.9679	NM_138689
PPP1R14B	hsa-miR-328-5p	86.9679	NM_138689
PPP1R14B	hsa-miR-548ac	81.8387	NM_138689
PPP1R14B	hsa-miR-548bb-3p	81.8387	NM_138689
PPP1R14B	hsa-miR-548z	81.8387	NM_138689
PPP1R14B	hsa-miR-548h-3p	81.8387	NM_138689
PPP1R14B	hsa-miR-548d-3p	81.8387	NM_138689
PPP1R14B	hsa-miR-548as-3p	81.4737	NM_138689

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Motifs and transcription factors (TFs) regulating PPP1R14B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPP1R14B	metacluster_155.31	ZNF131 (directAnnotation). ZNF131 (inferredBy_Orthology).
PPP1R14B	metacluster_31.8	RBPJ; RBPJ; RBPJ; RBPJ (directAnnotation). RBPJ; RBPJ; RBPJ; RBPJ; RBPJ (inferredBy_Orthology).
PPP1R14B	transfac_pro__M06469	ZNF441 (directAnnotation).
PPP1R14B	transfac_pro__M05525	ZBTB41 (directAnnotation).
PPP1R14B	taipale_tf_pairs__TEAD4_GSC2_RGWATGTTAATCCS_CAP_repr	GSC2; TEAD4 (directAnnotation).
PPP1R14B	transfac_pro__M06660	ZNF670 (directAnnotation).
PPP1R14B	transfac_pro__M05731	ZNF660 (directAnnotation).
PPP1R14B	taipale_tf_pairs__E2F3_DRGX_SGCGCTAATTKN_CAP_repr	DRGX; E2F3 (directAnnotation).
PPP1R14B	taipale_tf_pairs__PITX1_EOMES_GGATTANNARGTGTKN_CAP_repr	EOMES; PITX1 (directAnnotation).
PPP1R14B	jaspar__MA1608.1	ISL1 (inferredBy_Orthology).
PPP1R14B	tfdimers__MD00570	NEUROD1; NR3C1 (directAnnotation).
PPP1R14B	metacluster_55.5	ZNF541 (directAnnotation).
PPP1R14B	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
PPP1R14B	transfac_pro__M06852	ZNF549 (directAnnotation).
PPP1R14B	transfac_pro__M06969	EBF4 (inferredBy_Orthology).
PPP1R14B	homer__GKTAATGR_Nkx6.1	NKX6-1 (inferredBy_Orthology).
PPP1R14B	transfac_pro__M06995	NFE2L3 (directAnnotation).
PPP1R14B	taipale_tf_pairs__HOXA4_RTMATTAN_HT	HOXA4 (directAnnotation).
PPP1R14B	metacluster_51.29	HOXD8 (directAnnotation).
PPP1R14B	hdpi__JDP2	JDP2 (directAnnotation).
PPP1R14B	transfac_pro__M04906	SIN3A (directAnnotation).
PPP1R14B	taipale_tf_pairs__GCM2_TBX21_NNNCGGGNNNGGTGTNN_CAP_repr	GCM2; TBX21 (directAnnotation).
PPP1R14B	transfac_pro__M05722	ZNF8 (directAnnotation).
PPP1R14B	tfdimers__MD00599	NR1I2; RXRA; STAT1 (directAnnotation).
PPP1R14B	metacluster_70.17	POU1F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."