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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PPP1CC

Summary for PPP1CC

Gene information	Gene symbol	PPP1CC
	Ensembl ID	ENSG00000186298
	Entrez ID	5501
	Gene name	protein phosphatase 1 catalytic subunit gamma
	Synonyms	PP1C\|PP1gamma
	Gene type	protein_coding
	UniProtAcc	P36873

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Dataset with differentially expressed gene: PPP1CC

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.950852	3.10e-06
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.376214	3.38e-28
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.250804	1.06e-38
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.250438	1.75e-40
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.299431	1.36e-11
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.323964	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.500732	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.358438	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.380595	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.256759	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.459561	6.66e-43
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.275584	8.01e-13
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.365911	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.412252	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.376583	0.00e+00

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Expression of PPP1CC in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPP1CC

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPP1CC

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPP1CC	hsa-miR-493-5p	96.1508	NM_002710
PPP1CC	hsa-miR-568	96.1197	NM_002710
PPP1CC	hsa-let-7a-2-3p	95.2059	NM_002710
PPP1CC	hsa-miR-12136	94.4096	NM_002710
PPP1CC	hsa-miR-5696	94.3454	NM_002710
PPP1CC	hsa-let-7g-3p	93.9954	NM_002710
PPP1CC	hsa-miR-548aj-3p	93.7864	NM_002710
PPP1CC	hsa-miR-548x-3p	93.7864	NM_002710
PPP1CC	hsa-miR-218-5p	93.081	NM_002710
PPP1CC	hsa-miR-4719	92.7431	NM_002710
PPP1CC	hsa-miR-548ae-3p	91.8404	NM_002710
PPP1CC	hsa-miR-548am-3p	91.8404	NM_002710
PPP1CC	hsa-miR-548j-3p	91.8404	NM_002710
PPP1CC	hsa-miR-548ah-3p	91.8404	NM_002710
PPP1CC	hsa-miR-548aq-3p	91.8404	NM_002710
PPP1CC	hsa-miR-186-5p	91.8216	NM_002710
PPP1CC	hsa-miR-510-3p	91.0029	NM_002710
PPP1CC	hsa-miR-551b-5p	90.982	NM_002710
PPP1CC	hsa-miR-4680-3p	90.6512	NM_002710
PPP1CC	hsa-miR-12120	90.6059	NM_002710
PPP1CC	hsa-miR-4709-5p	90.2765	NM_002710
PPP1CC	hsa-miR-506-5p	89.7396	NM_001244974
PPP1CC	hsa-let-7c-3p	88.6067	NM_002710
PPP1CC	hsa-miR-372-5p	87.922	NM_002710
PPP1CC	hsa-miR-9851-5p	87.629	NM_002710
PPP1CC	hsa-miR-302c-5p	87.3911	NM_002710
PPP1CC	hsa-miR-8071	85.3021	NM_001244974
PPP1CC	hsa-miR-7109-3p	84.6281	NM_002710
PPP1CC	hsa-miR-586	84.2232	NM_002710
PPP1CC	hsa-miR-122b-3p	83.3686	NM_002710
PPP1CC	hsa-miR-21-3p	83.3686	NM_002710
PPP1CC	hsa-miR-579-3p	83.2407	NM_002710
PPP1CC	hsa-miR-3688-3p	83.0804	NM_002710
PPP1CC	hsa-miR-3662	82.5792	NM_002710
PPP1CC	hsa-miR-525-5p	81.7711	NM_002710
PPP1CC	hsa-miR-520a-5p	81.7711	NM_002710
PPP1CC	hsa-miR-421	81.6337	NM_002710
PPP1CC	hsa-miR-1253	81.3356	NM_001244974
PPP1CC	hsa-miR-664b-3p	80.96	NM_002710
PPP1CC	hsa-miR-128-3p	80.597	NM_002710
PPP1CC	hsa-miR-216a-3p	80.597	NM_002710
PPP1CC	hsa-miR-9985	80.174	NM_002710
PPP1CC	hsa-miR-27a-3p	80.174	NM_002710
PPP1CC	hsa-miR-27b-3p	80.174	NM_002710
PPP1CC	hsa-miR-8076	80.0694	NM_002710

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Motifs and transcription factors (TFs) regulating PPP1CC

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPP1CC	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PPP1CC	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
PPP1CC	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
PPP1CC	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
PPP1CC	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PPP1CC	swissregulon__hs__GLIS2	GLIS2 (directAnnotation).
PPP1CC	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
PPP1CC	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
PPP1CC	taipale_tf_pairs__GCM1_ERG_RTRYGGGCGGAARKN_CAP	ERG; GCM1 (directAnnotation).
PPP1CC	metacluster_84.2	RARA (directAnnotation).
PPP1CC	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
PPP1CC	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
PPP1CC	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PPP1CC	homer__AAGGKGRCGCAGGCA_ZNF165	ZNF165 (directAnnotation).
PPP1CC	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
PPP1CC	cisbp__M00341	PAX6 (directAnnotation).
PPP1CC	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
PPP1CC	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWGNNNNNTCCGGNN_CAP	GCM1; SPDEF (directAnnotation).
PPP1CC	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
PPP1CC	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
PPP1CC	tfdimers__MD00151	CHURC1 (directAnnotation).
PPP1CC	tfdimers__MD00391	KLF4 (directAnnotation).
PPP1CC	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
PPP1CC	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
PPP1CC	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PPP1CC	cisbp__M00968	MTF2 (directAnnotation).
PPP1CC	transfac_pro__M01973	PLAG1 (directAnnotation).
PPP1CC	transfac_pro__M12697	ZNF142 (directAnnotation).
PPP1CC	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
PPP1CC	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PPP1CC	transfac_pro__M01303	SP1 (directAnnotation).
PPP1CC	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
PPP1CC	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
PPP1CC	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
PPP1CC	transfac_public__M00491	PATZ1 (directAnnotation).
PPP1CC	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
PPP1CC	transfac_pro__M07397	ZNF148 (directAnnotation).
PPP1CC	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
PPP1CC	transfac_pro__M00492	STAT1 (directAnnotation).
PPP1CC	swissregulon__hs__ELK1	ELK1 (directAnnotation).
PPP1CC	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
PPP1CC	metacluster_183.4	ETS1 (inferredBy_Orthology).
PPP1CC	hocomoco__KAISO_HUMAN.H11MO.2.A	ZBTB33 (directAnnotation).
PPP1CC	jaspar__MA0502.2	NFYB (directAnnotation).
PPP1CC	taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAP	ETV2; TEF (directAnnotation).
PPP1CC	hdpi__NRL	NRL (directAnnotation).
PPP1CC	transfac_pro__M07310	SP5 (directAnnotation).
PPP1CC	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PPP1CC	metacluster_155.11	SPZ1 (directAnnotation).
PPP1CC	hdpi__HTATIP2	HTATIP2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PPP1CC	"9,10-Deepithio-9,10-Didehydroacanthifolicin"	DB02169	small molecule
PPP1CC	"Calyculin A"	DB02860	small molecule
PPP1CC	"Motuporin"	DB04738	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."