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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PNPLA8

Summary for PNPLA8

Gene information	Gene symbol	PNPLA8
	Ensembl ID	ENSG00000135241
	Entrez ID	50640
	Gene name	patatin like phospholipase domain containing 8
	Synonyms	IPLA2-2\|IPLA2G\|iPLA2gamma
	Gene type	protein_coding
	UniProtAcc	Q9NP80

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Dataset with differentially expressed gene: PNPLA8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.29669	5.99e-07
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.323026	1.14e-15
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.363776	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.445127	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.274426	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.324352	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.45863	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.462665	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.297873	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.284838	9.73e-10

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Expression of PNPLA8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PNPLA8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PNPLA8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PNPLA8	hsa-miR-3658	98.3011	NM_001256009
PNPLA8	hsa-miR-4495	95.307	NM_001256007
PNPLA8	hsa-miR-4504	94.1542	NM_001256009
PNPLA8	hsa-miR-6715b-3p	93.0766	NM_001256009
PNPLA8	hsa-miR-636	92.6863	NM_001256009
PNPLA8	hsa-miR-153-5p	92.1914	NM_001256009
PNPLA8	hsa-miR-875-3p	91.9051	NM_001256009
PNPLA8	hsa-miR-5696	89.7071	NM_001256007
PNPLA8	hsa-miR-561-3p	89.3352	NM_001256009
PNPLA8	hsa-miR-579-3p	86.599	NM_001256007
PNPLA8	hsa-miR-664b-3p	86.599	NM_001256007
PNPLA8	hsa-miR-6500-3p	86.1815	NM_001256009
PNPLA8	hsa-miR-5581-3p	85.9755	NM_001256009
PNPLA8	hsa-miR-218-5p	85.6974	NM_001256009
PNPLA8	hsa-miR-569	85.6954	NM_001256009
PNPLA8	hsa-miR-3686	84.6934	NM_001256007
PNPLA8	hsa-miR-302c-5p	80.9833	NM_001256007
PNPLA8	hsa-miR-4653-3p	80.6117	NM_001256009
PNPLA8	hsa-miR-4775	80.5567	NM_001256009

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Motifs and transcription factors (TFs) regulating PNPLA8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PNPLA8	hdpi__HIP2	UBE2K (directAnnotation).
PNPLA8	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
PNPLA8	hdpi__TIMELESS	TIMELESS (directAnnotation).
PNPLA8	metacluster_191.5	SPDEF (inferredBy_Orthology).
PNPLA8	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PNPLA8	transfac_pro__M00938	E2F1 (directAnnotation).
PNPLA8	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
PNPLA8	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
PNPLA8	hdpi__RARA	RARA (directAnnotation).
PNPLA8	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PNPLA8	hdpi__ELF2	ELF2 (directAnnotation).
PNPLA8	taipale_tf_pairs__TFAP2C_DLX3_NSCCNNNRGGCANNNNNNTAATKR_CAP_repr	DLX3; TFAP2C (directAnnotation).
PNPLA8	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PNPLA8	transfac_pro__M02898	SMAD3 (directAnnotation).
PNPLA8	hdpi__HTATIP2	HTATIP2 (directAnnotation).
PNPLA8	jaspar__MA1122.1	TFDP1 (directAnnotation).
PNPLA8	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
PNPLA8	transfac_pro__M07310	SP5 (directAnnotation).
PNPLA8	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PNPLA8	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
PNPLA8	cisbp__M00249	WT1 (directAnnotation).
PNPLA8	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
PNPLA8	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
PNPLA8	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
PNPLA8	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
PNPLA8	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
PNPLA8	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
PNPLA8	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
PNPLA8	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PNPLA8	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
PNPLA8	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
PNPLA8	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
PNPLA8	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
PNPLA8	transfac_pro__M12697	ZNF142 (directAnnotation).
PNPLA8	tfdimers__MD00364	WT1 (directAnnotation).
PNPLA8	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
PNPLA8	tfdimers__MD00483	ZBTB14 (directAnnotation).
PNPLA8	transfac_pro__M01303	SP1 (directAnnotation).
PNPLA8	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
PNPLA8	metacluster_143.13	ZBTB7A (directAnnotation).
PNPLA8	taipale_tf_pairs__ETV5_EOMES_RNGTGNNNNNNNNNNNNNRCRCCGGAWSN_CAP	EOMES; ETV5 (directAnnotation).
PNPLA8	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
PNPLA8	transfac_pro__M07387	ZBTB7A (directAnnotation).
PNPLA8	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
PNPLA8	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
PNPLA8	metacluster_144.13	HIC1; HIC1 (directAnnotation).
PNPLA8	transfac_pro__M00514	ATF4 (directAnnotation).
PNPLA8	transfac_pro__M00665	SP3 (directAnnotation).
PNPLA8	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
PNPLA8	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."