Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE140440 | DU145 and PCÂ cell lines | Cell line | Prostate cancer | Prostate cancer | Chemotherapy | docetaxel | NA | Malignant cells | -1.07991 | 4.06e-04 |
GSE138267 | CDX | Tumor tissue | Lung cancer | Small cell lung cancer (SCLC) | Chemotherapy | NA | NA | Malignant cells | 1.21124 | 0.00e+00 |
GSE169246_PacTissue | patients | Tumor tissue | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | post | Mono/Macro | 0.590892 | 4.35e-23 |
GSE169246_PacTissue | patients | Tumor tissue | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | Mono/Macro | 0.494834 | 4.77e-14 |
GSE164551 | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Immunotherapy | CAR-T | NA | Erythrocytes | -0.296631 | 5.18e-12 |
GSE164551 | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Immunotherapy | CAR-T | NA | Mono/Macro | 0.539543 | 2.60e-08 |
PMID34715028 | patients | Tumor tissue | Kidney cancer | Clear cell renal cell carcinoma (ccRCC) | Immunotherapy | nivolumab | post | CD8+ T cells | -0.395894 | 0.00e+00 |
PMID34715028 | patients | Tumor tissue | Kidney cancer | Clear cell renal cell carcinoma (ccRCC) | Immunotherapy | nivolumab | post | CD4+ T cells | -0.626563 | 0.00e+00 |
GSE207422_Sin | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | Mast cells | 1.44264 | 2.15e-02 |
GSE207422_Sin | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | Mono/Macro | 1.13642 | 9.34e-16 |
GSE207422_Tor | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | Mono/Macro | 0.505219 | 2.51e-06 |
GSE189460 | patients | Bone marrow aspirate | Multiple myeloma | Multiple myeloma (MM) | Targeted therapy | bortezomib + melphalan + prednisolone | pre | Mono/Macro | 0.326071 | 2.39e-41 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | Malignant cells | -0.584632 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | pre | Erythrocytes | -0.405112 | 4.45e-17 |
GSE175716 | PDX | Tumor tissue | Liver cancer | Advanced hepatocellular carcinoma | Targeted therapy | sorafenib | NA | Malignant cells | 3.31118 | 0.00e+00 |
GSE115251 | Kelly cell line | Cell line | Neuroblastoma | Neuroblastoma | Targeted therapy | TAE684 | NA | Malignant cells | -0.48885 | 0.00e+00 |
GSE164897_Vem | A375 cell line | Cell line | Melanoma | BRAFV600E-mutant melanoma | Targeted therapy | vemurafenib | NA | Malignant cells | 0.341912 | 0.00e+00 |
Gene symbol | motif | TF_highConf |
PLIN2 | hdpi__ZNF304 | ZNF304 (directAnnotation). |
PLIN2 | metacluster_125.2 | TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology). |
PLIN2 | transfac_pro__M04916 | TAF1 (directAnnotation). |
PLIN2 | tfdimers__MD00483 | ZBTB14 (directAnnotation). |
PLIN2 | metacluster_198.3 | ZFP64 (directAnnotation). |
PLIN2 | transfac_pro__M00803 | E2F1; E2F3; E2F4; TFDP1 (directAnnotation). |
PLIN2 | metacluster_143.13 | ZBTB7A (directAnnotation). |
PLIN2 | transfac_public__M00189 | TFAP2A; TFAP2B; TFAP2C (directAnnotation). |
PLIN2 | kznf__ZNF2_Imbeault2017_OM_RCADE | ZNF2 (directAnnotation). |
PLIN2 | kznf__ZNF213_Schmitges2016_RCADE | ZNF213 (directAnnotation). |
PLIN2 | taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth | E2F2 (directAnnotation). |
PLIN2 | transfac_pro__M06798 | PRDM15 (directAnnotation). |
PLIN2 | metacluster_22.34 | BACH2 (directAnnotation). |
PLIN2 | metacluster_50.1 | BATF; BATF; BATF; BATF; BNC2; FOS; FOSB; FOSL1; FOSL1; IRF4; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMAD2; SMAD3 (directAnnotation). BATF; BATF; BATF; FOS; FOSL1; FOSL2; JDP2; JUN; JUN; JUND (inferredBy_Orthology). |
PLIN2 | metacluster_22.32 | NFE2L2 (directAnnotation). |
PLIN2 | metacluster_22.13 | MAFK (inferredBy_Orthology). |
PLIN2 | transfac_pro__M05612 | ZNF189 (directAnnotation). |
PLIN2 | transfac_pro__M05884 | ZNF439 (directAnnotation). |
PLIN2 | transfac_pro__M06402 | ZNF493 (directAnnotation). |
PLIN2 | transfac_pro__M06504 | ZFP62 (directAnnotation). |
PLIN2 | transfac_pro__M06985 | BATF3 (directAnnotation). |
PLIN2 | tfdimers__MD00012 | ETS1; YY1 (directAnnotation). |
PLIN2 | tfdimers__MD00145 | ELF1; ELF2; ELK1; ELK4; ERF; ERG; ETS1; ETS2; ETV7; FLI1; TCF7L2 (directAnnotation). |
PLIN2 | transfac_pro__M06749 | ZNF222 (directAnnotation). |
PLIN2 | metacluster_198.1 | ZNF439 (directAnnotation). |
PLIN2 | taipale_tf_pairs__PITX1_TBX21_AGGTGNGAARGGATTA_CAP_repr | PITX1; TBX21 (directAnnotation). |
PLIN2 | jaspar__MA1963.1 | SATB1 (directAnnotation). |
PLIN2 | taipale_tf_pairs__TFAP2C_DRGX_SCCNNNGGCNNYAATTA_CAP_repr | DRGX; TFAP2C (directAnnotation). |
PLIN2 | tfdimers__MD00143 | IKZF1; MZF1 (directAnnotation). |
PLIN2 | transfac_pro__M05756 | ZNF470 (directAnnotation). |
PLIN2 | transfac_pro__M06733 | RBAK (directAnnotation). |
PLIN2 | transfac_pro__M06952 | BATF (directAnnotation). |
PLIN2 | transfac_pro__M05426 | ZFP91 (directAnnotation). |
PLIN2 | idmmpmm__fkh | FOXA2 (inferredBy_Orthology). |
PLIN2 | tfdimers__MD00051 | GABPA; STAT6 (directAnnotation). |
PLIN2 | transfac_pro__M05605 | GATA6 (inferredBy_Orthology). |
PLIN2 | metacluster_172.22 | E4F1 (inferredBy_Orthology). |
PLIN2 | metacluster_52.13 | LEF1; LEF1; LEF1; LEF1; TCF7; TCF7; TCF7L1; TCF7L1 (directAnnotation). |
PLIN2 | metacluster_103.2 | ZNF136; ZNF680 (directAnnotation). |
PLIN2 | tfdimers__MD00299 | ETS1; SRY (directAnnotation). |
PLIN2 | transfac_pro__M00716 | ZBTB14 (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |