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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PKIB

Summary for PKIB

Gene information	Gene symbol	PKIB
	Ensembl ID	ENSG00000135549
	Entrez ID	5570
	Gene name	cAMP-dependent protein kinase inhibitor beta
	Synonyms	PRKACN2
	Gene type	protein_coding
	UniProtAcc	Q9C010

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Dataset with differentially expressed gene: PKIB

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.722042	1.99e-18
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.839535	5.44e-04
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	cDCs	-0.389083	1.10e-02
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	-0.399355	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	cDCs	0.294745	4.88e-10
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.732269	3.63e-33
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.819958	9.81e-27
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.972465	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.545475	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	2.60092	0.00e+00

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Expression of PKIB in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PKIB

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PKIB

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PKIB	hsa-miR-9500	95.9407	NM_001270395
PKIB	hsa-miR-4753-3p	94.3983	NM_001270393
PKIB	hsa-miR-5696	93.4088	NM_001270393
PKIB	hsa-miR-4760-3p	93.3843	NM_001270395
PKIB	hsa-miR-6511b-3p	92.9527	NM_001270395
PKIB	hsa-miR-6511a-3p	92.9527	NM_001270395
PKIB	hsa-miR-4448	89.8747	NM_001270395
PKIB	hsa-miR-383-3p	89.0856	NM_001270393
PKIB	hsa-miR-8485	88.628	NM_001270395
PKIB	hsa-miR-548c-3p	86.8417	NM_001270395
PKIB	hsa-miR-5003-5p	86.1193	NM_001270395
PKIB	hsa-miR-633	85.6119	NM_001270395
PKIB	hsa-miR-1229-3p	84.96	NM_001270395
PKIB	hsa-miR-888-3p	84.7912	NM_001270395
PKIB	hsa-miR-450a-1-3p	82.8562	NM_001270395
PKIB	hsa-miR-6772-3p	82.6598	NM_001270395
PKIB	hsa-miR-10527-5p	81.821	NM_001270393
PKIB	hsa-miR-183-3p	81.808	NM_001270395

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Motifs and transcription factors (TFs) regulating PKIB

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PKIB	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
PKIB	metacluster_113.3	MYBL1; MYBL1; MYBL2; MYBL2; OVOL1; OVOL2 (directAnnotation). MYB; MYBL1; MYBL1; MYBL1; MYBL1; MYBL2; OVOL1 (inferredBy_Orthology).
PKIB	hdpi__MLX	MLX (directAnnotation).
PKIB	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
PKIB	taipale_tf_pairs__GCM1_HOXB13_NCCCGCANNMATAAA_CAP_repr	GCM1; HOXB13 (directAnnotation).
PKIB	metacluster_160.2	FEZF1; FEZF2 (directAnnotation).
PKIB	hocomoco__E2F8_HUMAN.H11MO.0.D	E2F8 (directAnnotation).
PKIB	transfac_pro__M06096	ZNF682 (directAnnotation).
PKIB	homer__TACGTGCV_HIF-1a	HIF1A (directAnnotation).
PKIB	transfac_pro__M05919	ZIM3 (directAnnotation).
PKIB	transfac_pro__M06678	ZNF287 (inferredBy_Orthology).
PKIB	kznf__ZNF354B_Imbeault2017_RP_RCADE	ZNF354B (directAnnotation).
PKIB	transfac_pro__M06062	ZNF623 (directAnnotation).
PKIB	tfdimers__MD00581	ATF5; NKX3-2 (directAnnotation).
PKIB	metacluster_79.34	GATA2; GATA5 (directAnnotation).
PKIB	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
PKIB	metacluster_82.6	ZNF211 (directAnnotation).
PKIB	metacluster_141.4	GLIS2 (directAnnotation).
PKIB	taipale_tf_pairs__CEBPG_ELF1_TTGCGYAANNSCGGAAGN_CAP_repr	CEBPG; ELF1 (directAnnotation).
PKIB	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
PKIB	transfac_pro__M06486	ZNF610 (directAnnotation).
PKIB	metacluster_178.20	ZKSCAN1 (directAnnotation). ZKSCAN1 (inferredBy_Orthology).
PKIB	taipale_tf_pairs__MYCL2_SCACGTGS_HT	MYCLP1 (directAnnotation).
PKIB	metacluster_141.2	E2F2; E2F3 (directAnnotation).
PKIB	transfac_pro__M05972	ZNF701 (directAnnotation).
PKIB	transfac_pro__M06064	ZNF729 (directAnnotation).
PKIB	transfac_pro__M06603	ZNF560 (directAnnotation).
PKIB	kznf__ZIM2_Imbeault2017_OM_MEME	ZIM2 (directAnnotation).
PKIB	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
PKIB	metacluster_31.3	ZSCAN20; ZSCAN29 (directAnnotation).
PKIB	jaspar__MA1532.2	NR1D2 (directAnnotation).
PKIB	hdpi__CREB1	CREB1 (directAnnotation).
PKIB	transfac_pro__M06161	ZNF117 (directAnnotation).
PKIB	taipale_cyt_meth__NKX2-3_NTCGTTGAN_eDBD_meth	NKX2-3 (directAnnotation).
PKIB	transfac_public__M00077	GATA3 (directAnnotation).
PKIB	transfac_pro__M06936	MAFF (inferredBy_Orthology).
PKIB	tfdimers__MD00158	DBP; ZNF354C (directAnnotation).
PKIB	transfac_pro__M05737	ZNF699 (directAnnotation).
PKIB	transfac_pro__M06458	ZNF441 (directAnnotation).
PKIB	metacluster_168.3	NR4A1 (directAnnotation).
PKIB	transfac_pro__M04955	ZBTB33 (directAnnotation).
PKIB	metacluster_75.4	SCRT1 (directAnnotation).
PKIB	taipale_tf_pairs__CLOCK_FIGLA_NCASSTGKNNNNNNNNNCACGTGN_CAP_repr	CLOCK; FIGLA (directAnnotation).
PKIB	transfac_pro__M06048	ZNF208 (directAnnotation).
PKIB	transfac_pro__M07362	NANOG (directAnnotation). NANOGP8 (inferredBy_Orthology).
PKIB	taipale_tf_pairs__TEAD4_HOXB13_RRAATGCARTAAA_CAP_repr	HOXB13; TEAD4 (directAnnotation).
PKIB	transfac_pro__M06349	ZNF629 (inferredBy_Orthology).
PKIB	transfac_pro__M06322	ZNF181 (directAnnotation).
PKIB	transfac_pro__M06267	ZNF805 (directAnnotation).
PKIB	metacluster_179.2	ZNF418 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."