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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PITPNC1

Summary for PITPNC1

Gene information	Gene symbol	PITPNC1
	Ensembl ID	ENSG00000154217
	Entrez ID	26207
	Gene name	phosphatidylinositol transfer protein cytoplasmic 1
	Synonyms	RDGB-BETA\|RDGBB\|RDGBB1
	Gene type	protein_coding
	UniProtAcc	Q9UKF7

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Dataset with differentially expressed gene: PITPNC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.23621	5.96e-05
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.266127	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.5073	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.355926	0.00e+00

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Expression of PITPNC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PITPNC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PITPNC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PITPNC1	hsa-miR-5011-5p	100	NM_181671
PITPNC1	hsa-miR-190a-3p	99.988	NM_181671
PITPNC1	hsa-miR-26a-5p	98.954	NM_181671
PITPNC1	hsa-miR-26b-5p	98.954	NM_181671
PITPNC1	hsa-miR-1297	98.9497	NM_181671
PITPNC1	hsa-miR-4465	98.6052	NM_181671
PITPNC1	hsa-miR-1200	97.61	NM_181671
PITPNC1	hsa-miR-3529-3p	96.8815	NM_181671
PITPNC1	hsa-miR-196a-1-3p	96.2668	NM_012417
PITPNC1	hsa-miR-449a	96.2144	NM_181671
PITPNC1	hsa-miR-34a-5p	96.2144	NM_181671
PITPNC1	hsa-miR-34c-5p	95.7335	NM_181671
PITPNC1	hsa-miR-449b-5p	95.7335	NM_181671
PITPNC1	hsa-miR-5702	94.5897	NM_012417
PITPNC1	hsa-miR-4282	94.3656	NM_181671
PITPNC1	hsa-miR-10527-5p	93.9037	NM_181671
PITPNC1	hsa-miR-7114-5p	93.0927	NM_181671
PITPNC1	hsa-miR-1251-3p	91.4952	NM_181671
PITPNC1	hsa-miR-4422	90.4605	NM_181671
PITPNC1	hsa-miR-12131	89.7726	NM_012417
PITPNC1	hsa-miR-4723-3p	89.7326	NM_012417
PITPNC1	hsa-miR-6769b-3p	89.7326	NM_012417
PITPNC1	hsa-miR-3183	89.7326	NM_012417
PITPNC1	hsa-miR-7153-3p	89.375	NM_181671
PITPNC1	hsa-miR-548p	89.3198	NM_181671
PITPNC1	hsa-miR-544b	88.569	NM_181671
PITPNC1	hsa-miR-4729	88.4377	NM_012417
PITPNC1	hsa-miR-4324	87.8622	NM_181671
PITPNC1	hsa-miR-3163	87.7542	NM_012417
PITPNC1	hsa-miR-3135b	87.6413	NM_181671
PITPNC1	hsa-miR-24-3p	86.4894	NM_012417
PITPNC1	hsa-miR-4291	86.3648	NM_181671
PITPNC1	hsa-miR-4633-5p	86.3414	NM_181671
PITPNC1	hsa-miR-607	85.6191	NM_181671
PITPNC1	hsa-miR-23b-3p	85.4027	NM_012417
PITPNC1	hsa-miR-23a-3p	85.4027	NM_012417
PITPNC1	hsa-miR-23c	85.4027	NM_012417
PITPNC1	hsa-miR-6771-3p	84.9507	NM_181671
PITPNC1	hsa-miR-4753-3p	84.5217	NM_012417
PITPNC1	hsa-miR-3123	84.509	NM_012417
PITPNC1	hsa-miR-9500	84.1183	NM_012417
PITPNC1	hsa-miR-550a-3p	83.2302	NM_012417
PITPNC1	hsa-miR-200c-5p	82.245	NM_012417
PITPNC1	hsa-miR-6765-3p	81.4061	NM_181671
PITPNC1	hsa-miR-3121-5p	81.2056	NM_181671
PITPNC1	hsa-miR-466	81.0119	NM_012417
PITPNC1	hsa-miR-2052	80.8635	NM_012417
PITPNC1	hsa-miR-6832-5p	80.1208	NM_012417

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Motifs and transcription factors (TFs) regulating PITPNC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PITPNC1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PITPNC1	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PITPNC1	cisbp__M00343	PAX6 (directAnnotation).
PITPNC1	transfac_pro__M12697	ZNF142 (directAnnotation).
PITPNC1	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
PITPNC1	transfac_pro__M00938	E2F1 (directAnnotation).
PITPNC1	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
PITPNC1	transfac_pro__M12694	ZFP14 (directAnnotation).
PITPNC1	transfac_pro__M01253	CNOT3 (directAnnotation).
PITPNC1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
PITPNC1	transfac_pro__M02090	E2F4 (directAnnotation).
PITPNC1	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
PITPNC1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
PITPNC1	transfac_pro__M07437	ZBTB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."