Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PHLDA1

Summary for PHLDA1

Gene information	Gene symbol	PHLDA1
	Ensembl ID	ENSG00000139289
	Entrez ID	22822
	Gene name	pleckstrin homology like domain family A member 1
	Synonyms	DT1P1B11\|PHRIP\|TDAG51
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: PHLDA1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.26963	1.93e-36
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.29111	1.02e-06
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD4+ T cells	0.290896	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	NK cells	-0.38591	7.07e-04
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.516775	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.276348	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.450386	1.83e-23
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.744067	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.57926	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.451234	2.97e-18
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.866452	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.49009	1.89e-22
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	2.22835	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-1.38379	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.7648	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.739905	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.39197	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.640111	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.468612	0.00e+00

Top

Expression of PHLDA1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to PHLDA1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating PHLDA1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PHLDA1	hsa-miR-5692a	95.2017	NM_007350
PHLDA1	hsa-miR-4422	92.5813	NM_007350
PHLDA1	hsa-miR-203a-3p	92.5803	NM_007350
PHLDA1	hsa-miR-30a-3p	92.4023	NM_007350
PHLDA1	hsa-miR-30d-3p	92.4023	NM_007350
PHLDA1	hsa-miR-30e-3p	92.4023	NM_007350
PHLDA1	hsa-miR-875-3p	92.2604	NM_007350
PHLDA1	hsa-miR-4503	91.9839	NM_007350
PHLDA1	hsa-miR-3613-3p	90.8863	NM_007350
PHLDA1	hsa-miR-1250-3p	90.5734	NM_007350
PHLDA1	hsa-miR-640	89.336	NM_007350
PHLDA1	hsa-miR-5695	89.0591	NM_007350
PHLDA1	hsa-miR-155-3p	88.8675	NM_007350
PHLDA1	hsa-miR-4262	88.5662	NM_007350
PHLDA1	hsa-miR-6809-3p	88.3085	NM_007350
PHLDA1	hsa-miR-570-3p	87.8986	NM_007350
PHLDA1	hsa-miR-3941	87.0656	NM_007350
PHLDA1	hsa-miR-3148	86.9618	NM_007350
PHLDA1	hsa-miR-3685	86.6234	NM_007350
PHLDA1	hsa-miR-7156-5p	86.57	NM_007350
PHLDA1	hsa-miR-371b-5p	86.2447	NM_007350
PHLDA1	hsa-miR-616-5p	86.2447	NM_007350
PHLDA1	hsa-miR-373-5p	86.2447	NM_007350
PHLDA1	hsa-miR-194-5p	86.2131	NM_007350
PHLDA1	hsa-miR-3915	85.7598	NM_007350
PHLDA1	hsa-miR-340-5p	85.4546	NM_007350
PHLDA1	hsa-miR-12123	84.8601	NM_007350
PHLDA1	hsa-miR-892c-5p	84.7089	NM_007350
PHLDA1	hsa-miR-181a-5p	84.6504	NM_007350
PHLDA1	hsa-miR-181d-5p	84.6504	NM_007350
PHLDA1	hsa-miR-181c-5p	84.6504	NM_007350
PHLDA1	hsa-miR-181b-5p	84.6504	NM_007350
PHLDA1	hsa-miR-2681-5p	84.4886	NM_007350
PHLDA1	hsa-miR-5579-3p	84.48	NM_007350
PHLDA1	hsa-miR-203a-5p	83.8133	NM_007350
PHLDA1	hsa-miR-3658	83.1897	NM_007350
PHLDA1	hsa-miR-548p	82.8345	NM_007350
PHLDA1	hsa-miR-4801	82.6197	NM_007350
PHLDA1	hsa-miR-4273	82.4976	NM_007350
PHLDA1	hsa-miR-3680-3p	82.1284	NM_007350
PHLDA1	hsa-miR-4712-3p	81.0876	NM_007350
PHLDA1	hsa-miR-5680	80.8934	NM_007350
PHLDA1	hsa-miR-5583-5p	80.2826	NM_007350
PHLDA1	hsa-miR-3129-3p	80.2826	NM_007350
PHLDA1	hsa-miR-3659	80.2701	NM_007350
PHLDA1	hsa-miR-10527-5p	80.0191	NM_007350

Page: 1

Top

Motifs and transcription factors (TFs) regulating PHLDA1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PHLDA1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
PHLDA1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
PHLDA1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
PHLDA1	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
PHLDA1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
PHLDA1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PHLDA1	transfac_pro__M00938	E2F1 (directAnnotation).
PHLDA1	transfac_pro__M04893	TAF1 (directAnnotation).
PHLDA1	transfac_pro__M04817	ZBTB33 (directAnnotation).
PHLDA1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
PHLDA1	transfac_pro__M12697	ZNF142 (directAnnotation).
PHLDA1	tfdimers__MD00364	WT1 (directAnnotation).
PHLDA1	transfac_pro__M04916	TAF1 (directAnnotation).
PHLDA1	transfac_pro__M01973	PLAG1 (directAnnotation).
PHLDA1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
PHLDA1	tfdimers__MD00483	ZBTB14 (directAnnotation).
PHLDA1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
PHLDA1	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
PHLDA1	transfac_pro__M07387	ZBTB7A (directAnnotation).
PHLDA1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
PHLDA1	metacluster_144.13	HIC1; HIC1 (directAnnotation).
PHLDA1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PHLDA1	transfac_pro__M02898	SMAD3 (directAnnotation).
PHLDA1	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
PHLDA1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
PHLDA1	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
PHLDA1	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
PHLDA1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
PHLDA1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
PHLDA1	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
PHLDA1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PHLDA1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PHLDA1	transfac_public__M00041	ATF2; JUN (directAnnotation).
PHLDA1	taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAP	ETV2; TEF (directAnnotation).
PHLDA1	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
PHLDA1	cisbp__M02645	ETS1 (directAnnotation).
PHLDA1	transfac_pro__M06825	ZSCAN12 (directAnnotation).
PHLDA1	tfdimers__MD00208	IRF1; LTF (directAnnotation).
PHLDA1	transfac_pro__M06375	ZNF629 (inferredBy_Orthology).
PHLDA1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PHLDA1	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
PHLDA1	hdpi__LARP1	LARP1 (directAnnotation).
PHLDA1	transfac_pro__M04887	TCF12 (directAnnotation).
PHLDA1	taipale_tf_pairs__FLI1_FOXI1_GAAAACCGAAAN_CAP_repr	FLI1; FOXI1 (directAnnotation).
PHLDA1	hdpi__SSBP3	SSBP3 (directAnnotation).
PHLDA1	metacluster_175.6	GRHL1; GRHL1; GRHL1; GRHL1; TFCP2 (directAnnotation).
PHLDA1	kznf__ZNF45_Imbeault2017_OM_RCADE	ZNF45 (directAnnotation).
PHLDA1	dbtfbs__ZNF610_HEK293_ENCSR691TXI_merged_N1	ZNF610 (directAnnotation).
PHLDA1	metacluster_5.1	HIVEP1; HIVEP1; NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; NFKB2; NFKB2; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELB; RELB (directAnnotation). NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; REL; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELB; RELB; RELB (inferredBy_Orthology).
PHLDA1	transfac_pro__M05352	ZNF692 (inferredBy_Orthology).

Page: 1 2 3

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."