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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PHIP

Summary for PHIP

Gene information	Gene symbol	PHIP
	Ensembl ID	ENSG00000146247
	Entrez ID	55023
	Gene name	pleckstrin homology domain interacting protein
	Synonyms	BRWD2\|DCAF14\|FLJ20705\|ndrp\|WDR11
	Gene type	protein_coding
	UniProtAcc	Q8WWQ0

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Dataset with differentially expressed gene: PHIP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.416874	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.260414	2.74e-08
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.288377	5.39e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.251377	1.06e-16
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.356582	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.250536	0.00e+00

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Expression of PHIP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PHIP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PHIP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PHIP	hsa-miR-5011-5p	100	NM_017934
PHIP	hsa-miR-190a-3p	100	NM_017934
PHIP	hsa-miR-4775	99.9752	NM_017934
PHIP	hsa-miR-3163	99.9432	NM_017934
PHIP	hsa-miR-5680	99.885	NM_017934
PHIP	hsa-miR-590-3p	99.8818	NM_017934
PHIP	hsa-miR-4789-3p	99.7137	NM_017934
PHIP	hsa-miR-95-5p	99.6988	NM_017934
PHIP	hsa-miR-203a-3p	99.4708	NM_017934
PHIP	hsa-let-7c-3p	99.4583	NM_017934
PHIP	hsa-miR-1277-5p	99.4376	NM_017934
PHIP	hsa-miR-5692a	99.4133	NM_017934
PHIP	hsa-miR-4282	99.2024	NM_017934
PHIP	hsa-miR-568	99.0608	NM_017934
PHIP	hsa-miR-3924	98.928	NM_017934
PHIP	hsa-miR-4694-3p	98.8661	NM_017934
PHIP	hsa-miR-513c-3p	98.8605	NM_017934
PHIP	hsa-miR-513a-3p	98.8605	NM_017934
PHIP	hsa-miR-12136	98.7225	NM_017934
PHIP	hsa-miR-20a-3p	98.6529	NM_017934
PHIP	hsa-miR-4482-3p	98.6492	NM_017934
PHIP	hsa-miR-548c-3p	98.5281	NM_017934
PHIP	hsa-miR-548az-5p	98.5228	NM_017934
PHIP	hsa-miR-548t-5p	98.5228	NM_017934
PHIP	hsa-miR-548ar-3p	98.4413	NM_017934
PHIP	hsa-miR-3606-3p	98.291	NM_017934
PHIP	hsa-miR-96-5p	97.8536	NM_017934
PHIP	hsa-miR-548e-3p	97.8122	NM_017934
PHIP	hsa-miR-548a-3p	97.8122	NM_017934
PHIP	hsa-miR-548f-3p	97.8122	NM_017934
PHIP	hsa-miR-548bc	97.8122	NM_017934
PHIP	hsa-miR-579-3p	97.7969	NM_017934
PHIP	hsa-miR-664b-3p	97.7969	NM_017934
PHIP	hsa-miR-5696	97.6764	NM_017934
PHIP	hsa-miR-12133	97.6507	NM_017934
PHIP	hsa-miR-1271-5p	97.6507	NM_017934
PHIP	hsa-miR-6509-3p	97.5947	NM_017934
PHIP	hsa-miR-548az-3p	97.5569	NM_017934
PHIP	hsa-miR-7152-5p	97.4036	NM_017934
PHIP	hsa-miR-664a-3p	97.3336	NM_017934
PHIP	hsa-miR-607	97.123	NM_017934
PHIP	hsa-miR-335-3p	97.115	NM_017934
PHIP	hsa-miR-4703-5p	96.9778	NM_017934
PHIP	hsa-miR-186-5p	96.8328	NM_017934
PHIP	hsa-miR-520d-5p	96.8294	NM_017934
PHIP	hsa-miR-524-5p	96.8294	NM_017934
PHIP	hsa-miR-5582-3p	96.6002	NM_017934
PHIP	hsa-miR-3646	95.974	NM_017934
PHIP	hsa-miR-3686	95.9414	NM_017934
PHIP	hsa-miR-3614-5p	95.8755	NM_017934

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Motifs and transcription factors (TFs) regulating PHIP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PHIP	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
PHIP	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PHIP	jaspar__MA0748.2	YY2 (directAnnotation).
PHIP	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
PHIP	transfac_pro__M00652	NRF1 (directAnnotation).
PHIP	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PHIP	hdpi__EBF1	EBF1 (directAnnotation).
PHIP	metacluster_101.3	MYB (directAnnotation).
PHIP	hdpi__TP73	TP73 (directAnnotation).
PHIP	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
PHIP	transfac_pro__M04950	EGR1 (directAnnotation).
PHIP	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
PHIP	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
PHIP	taipale_tf_pairs__E2F3_EOMES_NNGYGNNNNGGCGCSNNNNCRCNN_CAP_repr	E2F3; EOMES (directAnnotation).
PHIP	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PHIP	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PHIP	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
PHIP	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
PHIP	hdpi__TIMELESS	TIMELESS (directAnnotation).
PHIP	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_repr	ZNF385D (directAnnotation).
PHIP	transfac_pro__M05893	ZNF676 (directAnnotation).
PHIP	taipale_tf_pairs__E2F1_EOMES_RGGTGTNNNGGCGSNNTNNCRSNN_CAP	E2F1; EOMES (directAnnotation).
PHIP	transfac_pro__M06340	ZNF790 (directAnnotation).
PHIP	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
PHIP	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
PHIP	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
PHIP	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
PHIP	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
PHIP	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
PHIP	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PHIP	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
PHIP	transfac_pro__M12686	ZBTB10 (directAnnotation).
PHIP	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PHIP	metacluster_143.14	ZNF320 (directAnnotation).
PHIP	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
PHIP	dbtfbs__ZBTB10_HEK293_ENCSR004PLU_merged_N1	ZBTB10 (directAnnotation).
PHIP	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
PHIP	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
PHIP	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
PHIP	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PHIP	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
PHIP	kznf__ZNF141_Imbeault2017_RP_RCADE	ZNF141 (directAnnotation).
PHIP	transfac_pro__M04617	ZBTB7A (directAnnotation).
PHIP	transfac_pro__M01973	PLAG1 (directAnnotation).
PHIP	metacluster_151.2	ZNF23 (directAnnotation).
PHIP	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PHIP	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
PHIP	metacluster_66.1	MTF1; ZNF320; ZNF320; ZNF320; ZNF782 (directAnnotation).
PHIP	cisbp__M01864	EGR1 (inferredBy_Orthology).
PHIP	tfdimers__MD00391	KLF4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."