Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PHC2

Summary for PHC2

Gene information	Gene symbol	PHC2
	Ensembl ID	ENSG00000134686
	Entrez ID	1912
	Gene name	polyhomeotic homolog 2
	Synonyms	EDR2\|HPH2
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: PHC2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.691476	7.27e-24
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.546452	5.21e-19
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.354254	1.01e-17
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.31464	9.83e-10
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.520718	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.415438	3.65e-28
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.324387	0.00e+00

Top

Expression of PHC2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to PHC2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating PHC2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PHC2	hsa-miR-4254	89.8309	NM_004427
PHC2	hsa-miR-6778-5p	86.6661	NM_004427
PHC2	hsa-miR-6889-3p	83.5524	NM_004427
PHC2	hsa-miR-766-5p	82.3994	NM_004427
PHC2	hsa-miR-6870-5p	82.1643	NM_004427
PHC2	hsa-miR-4723-5p	82.1643	NM_004427
PHC2	hsa-miR-5698	82.1643	NM_004427
PHC2	hsa-miR-7111-5p	82.1643	NM_004427
PHC2	hsa-miR-365a-5p	81.7293	NM_004427
PHC2	hsa-miR-365b-5p	81.7293	NM_004427
PHC2	hsa-miR-4749-3p	80.1764	NM_004427

Page: 1

Top

Motifs and transcription factors (TFs) regulating PHC2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PHC2	metacluster_155.36	ZNF729 (directAnnotation).
PHC2	transfac_pro__M06484	ZNF683 (directAnnotation).
PHC2	transfac_pro__M06556	ZNF383 (directAnnotation).
PHC2	transfac_pro__M05991	ZFP64 (directAnnotation).
PHC2	homer__GGAAATTCCC_NFkB-p65-Rel	RELA (inferredBy_Orthology).
PHC2	transfac_pro__M06071	ZNF814 (directAnnotation).
PHC2	transfac_pro__M05995	ZNF180 (directAnnotation).
PHC2	transfac_pro__M05877	ZNF467 (inferredBy_Orthology).
PHC2	metacluster_52.11	ZNF184 (directAnnotation).
PHC2	taipale_tf_pairs__ETV7_TBX21_NSCGGAARNNNNNTCACACNN_CAP_repr	ETV7; TBX21 (directAnnotation).
PHC2	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
PHC2	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
PHC2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PHC2	transfac_public__M00240	NKX2-5 (directAnnotation).
PHC2	metacluster_100.2	ZNF440 (directAnnotation).
PHC2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."