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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PHACTR1

Summary for PHACTR1

Gene information	Gene symbol	PHACTR1
	Ensembl ID	ENSG00000112137
	Entrez ID	221692
	Gene name	phosphatase and actin regulator 1
	Synonyms	dJ257A7.2\|KIAA1733\|RPEL1
	Gene type	protein_coding
	UniProtAcc	Q9C0D0

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Dataset with differentially expressed gene: PHACTR1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.439299	1.55e-16
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.468428	4.07e-09
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	1.13734	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	cDCs	-0.57042	1.64e-37
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.73019	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Mono/Macro	-0.284852	4.44e-36
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.461658	0.00e+00

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Expression of PHACTR1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PHACTR1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PHACTR1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PHACTR1	hsa-miR-3714	95.4881	NM_001242648
PHACTR1	hsa-miR-218-2-3p	94.3388	NM_001322314
PHACTR1	hsa-miR-2052	94.3167	NM_001242648
PHACTR1	hsa-miR-4659b-3p	94.0216	NM_001322314
PHACTR1	hsa-miR-4659a-3p	94.0216	NM_001322314
PHACTR1	hsa-miR-634	91.8055	NM_001242648
PHACTR1	hsa-miR-4725-3p	91.3427	NM_001322314
PHACTR1	hsa-miR-6780b-5p	91.3427	NM_001322314
PHACTR1	hsa-miR-2682-5p	91.251	NM_001242648
PHACTR1	hsa-miR-34b-5p	91.251	NM_001242648
PHACTR1	hsa-miR-449c-5p	91.251	NM_001242648
PHACTR1	hsa-miR-4307	90.4323	NM_001242648
PHACTR1	hsa-miR-548an	90.296	NM_001242648
PHACTR1	hsa-miR-4271	89.5348	NM_001322314
PHACTR1	hsa-miR-758-5p	89.4556	NM_001242648
PHACTR1	hsa-miR-383-3p	88.6307	NM_001242648
PHACTR1	hsa-miR-584-5p	88.1825	NM_001242648
PHACTR1	hsa-miR-548au-3p	88.0092	NM_001242648
PHACTR1	hsa-miR-6756-3p	83.6397	NM_001322314
PHACTR1	hsa-miR-3127-3p	83.6397	NM_001322314
PHACTR1	hsa-miR-361-3p	81.1756	NM_001322314
PHACTR1	hsa-miR-182-3p	80.2237	NM_001322314
PHACTR1	hsa-miR-597-3p	80.2237	NM_001322314

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Motifs and transcription factors (TFs) regulating PHACTR1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PHACTR1	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
PHACTR1	taipale_tf_pairs__GCM1_MAX_CACGTGNNNGCGGGY_CAP	GCM1; MAX (directAnnotation).
PHACTR1	swissregulon__hs__DBP	DBP (directAnnotation).
PHACTR1	tfdimers__MD00411	ELF5; YY1 (directAnnotation).
PHACTR1	taipale_tf_pairs__GCM1_MAX_NNCACGTGNNNGCGGGYN_CAP_repr	GCM1; MAX (directAnnotation).
PHACTR1	transfac_pro__M06346	E4F1 (directAnnotation).
PHACTR1	transfac_pro__M06217	ZNF169 (directAnnotation).
PHACTR1	cisbp__M00809	PRDM11 (inferredBy_Orthology).
PHACTR1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PHACTR1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
PHACTR1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
PHACTR1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
PHACTR1	tfdimers__MD00299	ETS1; SRY (directAnnotation).
PHACTR1	tfdimers__MD00143	IKZF1; MZF1 (directAnnotation).
PHACTR1	metacluster_162.5	NR1D1; NR1D1; RORA; RORA; RORA; RORA; RORA; RORC; RORC (directAnnotation). NR1D1; PPARG; RORA; RORC (inferredBy_Orthology).
PHACTR1	taipale_tf_pairs__POU2F1_SOX15_WTGMATAACAATR_CAP_1	POU2F1; SOX15 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."