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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PDCD4

Summary for PDCD4

Gene information	Gene symbol	PDCD4
	Ensembl ID	ENSG00000150593
	Entrez ID	27250
	Gene name	programmed cell death 4
	Synonyms	H731
	Gene type	protein_coding
	UniProtAcc	Q53EL6

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Dataset with differentially expressed gene: PDCD4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.16182	1.39e-10
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	0.259079	1.43e-39
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.252316	8.07e-28
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.358787	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.259038	3.02e-18
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.279904	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD8+ T cells	-0.342941	1.09e-31
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.30261	5.21e-23
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.442322	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.580583	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	0.618181	4.50e-28
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.362561	1.11e-26
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.443311	4.72e-34
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	0.258347	0.00e+00

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Expression of PDCD4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PDCD4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
PDCD4	Epigenetic Alteration of DNA, RNA or Protein
PDCD4	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating PDCD4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PDCD4	hsa-miR-3674	96.4605	NM_001199492
PDCD4	hsa-miR-1-3p	96.076	NM_001199492
PDCD4	hsa-miR-206	96.076	NM_001199492
PDCD4	hsa-miR-670-5p	95.5359	NM_001199492
PDCD4	hsa-miR-613	95.1855	NM_001199492
PDCD4	hsa-miR-580-5p	94.3151	NM_001199492
PDCD4	hsa-miR-5579-3p	93.9176	NM_001199492
PDCD4	hsa-miR-890	93.8231	NM_001199492
PDCD4	hsa-miR-4308	93.474	NM_001199492
PDCD4	hsa-miR-499a-5p	93.1282	NM_001199492
PDCD4	hsa-miR-21-5p	92.4263	NM_001199492
PDCD4	hsa-miR-6826-3p	91.9756	NM_001199492
PDCD4	hsa-miR-4436b-5p	91.9653	NM_001199492
PDCD4	hsa-miR-183-5p	91.9212	NM_001199492
PDCD4	hsa-miR-186-3p	91.7157	NM_001199492
PDCD4	hsa-miR-135b-3p	91.7152	NM_001199492
PDCD4	hsa-miR-4282	90.8172	NM_001199492
PDCD4	hsa-miR-590-5p	90.7203	NM_001199492
PDCD4	hsa-miR-6505-5p	90.626	NM_001199492
PDCD4	hsa-miR-4666a-5p	90.3468	NM_001199492
PDCD4	hsa-miR-520f-3p	90.2098	NM_001199492
PDCD4	hsa-miR-5584-5p	89.9933	NM_001199492
PDCD4	hsa-miR-153-5p	89.6565	NM_001199492
PDCD4	hsa-miR-3613-3p	89.5127	NM_001199492
PDCD4	hsa-miR-6760-3p	88.8201	NM_001199492
PDCD4	hsa-miR-942-3p	87.8123	NM_001199492
PDCD4	hsa-miR-9-3p	87.4682	NM_001199492
PDCD4	hsa-miR-135a-2-3p	87.4396	NM_001199492
PDCD4	hsa-miR-145-5p	87.3663	NM_001199492
PDCD4	hsa-miR-5195-3p	87.3663	NM_001199492
PDCD4	hsa-miR-4262	86.2669	NM_001199492
PDCD4	hsa-miR-208b-3p	86.1526	NM_001199492
PDCD4	hsa-miR-208a-3p	86.1526	NM_001199492
PDCD4	hsa-miR-4640-3p	85.7005	NM_001199492
PDCD4	hsa-miR-4312	84.1182	NM_001199492
PDCD4	hsa-miR-6720-5p	84.0521	NM_001199492
PDCD4	hsa-miR-6512-3p	84.0521	NM_001199492
PDCD4	hsa-miR-3163	83.8808	NM_001199492
PDCD4	hsa-miR-769-5p	83.7774	NM_001199492
PDCD4	hsa-miR-3658	83.7658	NM_001199492
PDCD4	hsa-miR-323a-3p	83.7233	NM_001199492
PDCD4	hsa-miR-4292	83.1469	NM_001199492
PDCD4	hsa-miR-6791-5p	83.1469	NM_001199492
PDCD4	hsa-miR-4680-3p	82.787	NM_001199492
PDCD4	hsa-miR-3617-5p	81.9401	NM_001199492
PDCD4	hsa-miR-641	81.9401	NM_001199492
PDCD4	hsa-miR-6831-3p	81.9192	NM_001199492
PDCD4	hsa-miR-3180-5p	81.7974	NM_001199492
PDCD4	hsa-miR-6798-3p	81.0568	NM_001199492
PDCD4	hsa-miR-186-5p	80.6851	NM_001199492

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Motifs and transcription factors (TFs) regulating PDCD4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PDCD4	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
PDCD4	metacluster_191.5	SPDEF (inferredBy_Orthology).
PDCD4	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PDCD4	transfac_pro__M00938	E2F1 (directAnnotation).
PDCD4	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
PDCD4	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
PDCD4	hdpi__RARA	RARA (directAnnotation).
PDCD4	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PDCD4	hdpi__ELF2	ELF2 (directAnnotation).
PDCD4	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PDCD4	cisbp__M00968	MTF2 (directAnnotation).
PDCD4	transfac_pro__M02898	SMAD3 (directAnnotation).
PDCD4	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PDCD4	hdpi__HTATIP2	HTATIP2 (directAnnotation).
PDCD4	jaspar__MA1721.1	ZNF93 (directAnnotation).
PDCD4	transfac_pro__M04916	TAF1 (directAnnotation).
PDCD4	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PDCD4	jaspar__MA1122.1	TFDP1 (directAnnotation).
PDCD4	transfac_pro__M07310	SP5 (directAnnotation).
PDCD4	cisbp__M01863	ZNF711 (inferredBy_Orthology).
PDCD4	metacluster_182.10	ZFX (directAnnotation).
PDCD4	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
PDCD4	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PDCD4	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
PDCD4	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
PDCD4	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
PDCD4	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PDCD4	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PDCD4	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
PDCD4	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
PDCD4	transfac_pro__M06448	ZNF808 (directAnnotation).
PDCD4	transfac_pro__M06181	ZNF165 (directAnnotation).
PDCD4	transfac_pro__M08187	ABL1 (directAnnotation).
PDCD4	tfdimers__MD00453	ATF3; CRX (directAnnotation).
PDCD4	jaspar__MA0079.5	SP1 (directAnnotation).
PDCD4	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
PDCD4	transfac_pro__M01253	CNOT3 (directAnnotation).
PDCD4	transfac_pro__M04817	ZBTB33 (directAnnotation).
PDCD4	cisbp__M07938	E2F1 (directAnnotation).
PDCD4	cisbp__M00161	FOXJ1 (inferredBy_Orthology).
PDCD4	transfac_pro__M07260	IKZF1 (directAnnotation).
PDCD4	transfac_pro__M01835	KLF4 (directAnnotation).
PDCD4	hocomoco__PATZ1_HUMAN.H11MO.1.C	PATZ1 (directAnnotation).
PDCD4	swissregulon__hs__MTA3	MTA3 (directAnnotation).
PDCD4	transfac_pro__M07270	TEAD4 (directAnnotation).
PDCD4	tfdimers__MD00351	IRF8; RFX1; RFX2; RFX3; RFX4; RFX5; RFXANK; RFXAP (directAnnotation).
PDCD4	transfac_pro__M06715	ZNF331 (directAnnotation).
PDCD4	metacluster_167.5	EHF; ELF5; NFATC3; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIC; SPIC; STAT5A (directAnnotation). ETS1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPIB; SPIC (inferredBy_Orthology).
PDCD4	jaspar__MA1125.1	ZNF384 (directAnnotation).
PDCD4	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_repr	ZNF385D (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."