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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PCM1

Summary for PCM1

Gene information	Gene symbol	PCM1
	Ensembl ID	ENSG00000078674
	Entrez ID	5108
	Gene name	pericentriolar material 1
	Synonyms	PTC4
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PCM1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.396233	2.82e-18
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.487696	2.61e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.341482	3.02e-28
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.400336	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.268987	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.321376	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.253629	2.53e-31
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.640341	0.00e+00

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Expression of PCM1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PCM1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PCM1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PCM1	hsa-miR-1185-1-3p	97.0421	NM_006197
PCM1	hsa-miR-1185-2-3p	97.0421	NM_006197
PCM1	hsa-let-7f-2-3p	97.0421	NM_006197
PCM1	hsa-miR-586	94.1736	NM_006197
PCM1	hsa-miR-5683	94.1591	NM_006197
PCM1	hsa-miR-495-3p	91.5344	NM_006197
PCM1	hsa-miR-5688	91.0581	NM_006197
PCM1	hsa-miR-2110	89.7521	NM_006197
PCM1	hsa-miR-625-5p	89.3145	NM_006197
PCM1	hsa-miR-499a-3p	89.0525	NM_001315507
PCM1	hsa-miR-499b-3p	89.0525	NM_001315507
PCM1	hsa-miR-548at-5p	88.2269	NM_006197
PCM1	hsa-miR-12115	87.0779	NM_006197
PCM1	hsa-miR-5696	86.899	NM_006197
PCM1	hsa-miR-548e-5p	86.3941	NM_006197
PCM1	hsa-miR-329-5p	85.0626	NM_006197
PCM1	hsa-miR-4796-3p	85.0273	NM_006197
PCM1	hsa-miR-32-3p	84.092	NM_001315507
PCM1	hsa-miR-335-3p	84.0256	NM_006197
PCM1	hsa-miR-4668-5p	83.5123	NM_006197
PCM1	hsa-miR-670-5p	82.6056	NM_006197
PCM1	hsa-miR-4302	82.5529	NM_001315507
PCM1	hsa-miR-3129-3p	82.3309	NM_006197
PCM1	hsa-miR-5583-5p	82.3309	NM_006197
PCM1	hsa-miR-7110-3p	82.181	NM_006197
PCM1	hsa-miR-6867-3p	82.0937	NM_006197
PCM1	hsa-miR-3935	81.5718	NM_006197
PCM1	hsa-miR-148a-5p	81.5602	NM_006197
PCM1	hsa-miR-6794-5p	81.139	NM_006197
PCM1	hsa-miR-4716-3p	81.139	NM_006197

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Motifs and transcription factors (TFs) regulating PCM1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PCM1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PCM1	cisbp__M00788	ZFY (inferredBy_Orthology).
PCM1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
PCM1	metacluster_175.1	ZNF283 (directAnnotation).
PCM1	hdpi__ZNF304	ZNF304 (directAnnotation).
PCM1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
PCM1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PCM1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PCM1	transfac_pro__M01199	TRIM28 (directAnnotation).
PCM1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
PCM1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PCM1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PCM1	transfac_pro__M03806	ZBTB7C (directAnnotation).
PCM1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PCM1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
PCM1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
PCM1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
PCM1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
PCM1	transfac_pro__M00430	E2F1 (directAnnotation).
PCM1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
PCM1	transfac_pro__M04893	TAF1 (directAnnotation).
PCM1	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
PCM1	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
PCM1	hdpi__HIP2	UBE2K (directAnnotation).
PCM1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
PCM1	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
PCM1	metacluster_191.5	SPDEF (inferredBy_Orthology).
PCM1	transfac_pro__M00938	E2F1 (directAnnotation).
PCM1	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
PCM1	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
PCM1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
PCM1	hdpi__RARA	RARA (directAnnotation).
PCM1	hdpi__ELF2	ELF2 (directAnnotation).
PCM1	taipale_tf_pairs__TFAP2C_DLX3_NSCCNNNRGGCANNNNNNTAATKR_CAP_repr	DLX3; TFAP2C (directAnnotation).
PCM1	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
PCM1	jaspar__MA1583.1	ZFP57 (directAnnotation).
PCM1	transfac_pro__M02898	SMAD3 (directAnnotation).
PCM1	hdpi__HTATIP2	HTATIP2 (directAnnotation).
PCM1	jaspar__MA1721.1	ZNF93 (directAnnotation).
PCM1	transfac_pro__M04916	TAF1 (directAnnotation).
PCM1	jaspar__MA1122.1	TFDP1 (directAnnotation).
PCM1	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
PCM1	transfac_pro__M07310	SP5 (directAnnotation).
PCM1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PCM1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
PCM1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
PCM1	cisbp__M00249	WT1 (directAnnotation).
PCM1	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
PCM1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
PCM1	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."