Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PALLD

Summary for PALLD

Gene information	Gene symbol	PALLD
	Ensembl ID	ENSG00000129116
	Entrez ID	23022
	Gene name	palladin, cytoskeletal associated protein
	Synonyms	CGI-151\|KIAA0992\|SIH002
	Gene type	protein_coding
	UniProtAcc	Q8WX93

Top

Dataset with differentially expressed gene: PALLD

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.422515	2.50e-22
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.3313	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.274589	0.00e+00
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.354413	2.15e-26
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.278759	2.68e-16
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.455195	1.07e-33
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.853866	0.00e+00

Top

Expression of PALLD in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to PALLD

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating PALLD

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PALLD	hsa-miR-182-5p	98.9494	NM_001166108
PALLD	hsa-miR-124-3p	98.5124	NM_001166108
PALLD	hsa-miR-506-3p	98.5124	NM_001166108
PALLD	hsa-miR-96-5p	97.1138	NM_001166108
PALLD	hsa-miR-340-5p	96.7653	NM_001166108
PALLD	hsa-miR-4718	96.3233	NM_001166108
PALLD	hsa-miR-545-3p	96.1183	NM_001166108
PALLD	hsa-miR-338-5p	95.7302	NM_001166110
PALLD	hsa-miR-1271-5p	95.5792	NM_001166108
PALLD	hsa-miR-12133	95.5792	NM_001166108
PALLD	hsa-miR-19b-1-5p	94.9214	NM_001166110
PALLD	hsa-miR-19a-5p	94.9214	NM_001166110
PALLD	hsa-miR-19b-2-5p	94.9214	NM_001166110
PALLD	hsa-miR-3680-3p	93.4609	NM_001166110
PALLD	hsa-miR-5692a	93.0217	NM_001166108
PALLD	hsa-miR-4672	92.9971	NM_001166108
PALLD	hsa-miR-548an	92.4384	NM_001166108
PALLD	hsa-miR-32-5p	92.1976	NM_001166108
PALLD	hsa-miR-92b-3p	92.1976	NM_001166108
PALLD	hsa-miR-92a-3p	92.1976	NM_001166108
PALLD	hsa-miR-6815-5p	92.121	NM_001166110
PALLD	hsa-miR-6865-5p	92.121	NM_001166110
PALLD	hsa-miR-6738-3p	91.813	NM_001166108
PALLD	hsa-miR-3163	91.8027	NM_001166108
PALLD	hsa-miR-5008-3p	91.7999	NM_001166110
PALLD	hsa-miR-7157-3p	91.6729	NM_001166110
PALLD	hsa-miR-6737-3p	91.6729	NM_001166110
PALLD	hsa-miR-5001-3p	91.4676	NM_001166108
PALLD	hsa-miR-5583-3p	91.331	NM_001166110
PALLD	hsa-miR-600	91.0979	NM_001166108
PALLD	hsa-miR-6529-3p	90.88	NM_001166110
PALLD	hsa-miR-6889-3p	90.5122	NM_001166110
PALLD	hsa-miR-363-3p	90.4881	NM_001166108
PALLD	hsa-miR-25-3p	90.4881	NM_001166108
PALLD	hsa-miR-367-3p	90.4881	NM_001166108
PALLD	hsa-miR-3973	90.0747	NM_001166108
PALLD	hsa-miR-2116-5p	89.8607	NM_001166108
PALLD	hsa-miR-3667-3p	89.8566	NM_001166110
PALLD	hsa-miR-4666a-3p	88.9799	NM_001166108
PALLD	hsa-miR-320c	88.9706	NM_001166108
PALLD	hsa-miR-320a-3p	88.9706	NM_001166108
PALLD	hsa-miR-4429	88.9706	NM_001166108
PALLD	hsa-miR-320b	88.9706	NM_001166108
PALLD	hsa-miR-320d	88.9706	NM_001166108
PALLD	hsa-miR-8066	88.6306	NM_001166110
PALLD	hsa-miR-511-3p	88.3486	NM_001166110
PALLD	hsa-miR-4483	88.1134	NM_001166110
PALLD	hsa-miR-3617-3p	87.6225	NM_001166110
PALLD	hsa-miR-518a-5p	87.4661	NM_001166108
PALLD	hsa-miR-527	87.4661	NM_001166108

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating PALLD

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PALLD	transfac_pro__M01199	TRIM28 (directAnnotation).
PALLD	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
PALLD	metacluster_151.2	ZNF23 (directAnnotation).
PALLD	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PALLD	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PALLD	transfac_pro__M03806	ZBTB7C (directAnnotation).
PALLD	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PALLD	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
PALLD	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
PALLD	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
PALLD	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
PALLD	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
PALLD	cisbp__M02645	ETS1 (directAnnotation).
PALLD	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
PALLD	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
PALLD	jaspar__MA1708.1	ETV7 (directAnnotation).
PALLD	swissregulon__hs__ELK1	ELK1 (directAnnotation).
PALLD	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
PALLD	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PALLD	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
PALLD	transfac_pro__M00492	STAT1 (directAnnotation).
PALLD	metacluster_22.29	NFE2 (directAnnotation).
PALLD	metacluster_22.25	NFE2L2 (directAnnotation).
PALLD	jaspar__MA0502.2	NFYB (directAnnotation).
PALLD	metacluster_22.18	BACH2 (inferredBy_Orthology).
PALLD	metacluster_22.32	NFE2L2 (directAnnotation).
PALLD	transfac_pro__M05683	ZNF280A (directAnnotation).
PALLD	metacluster_178.3	NKX1-1; NKX1-2 (directAnnotation). GSX1; HOXB2; HOXB3 (inferredBy_Orthology).
PALLD	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
PALLD	metacluster_22.34	BACH2 (directAnnotation).
PALLD	taipale_tf_pairs__TEAD4_PITX1_RCATWCNNNNNGGATTA_CAP_repr	PITX1; TEAD4 (directAnnotation).
PALLD	metacluster_22.28	BACH1 (directAnnotation).
PALLD	jaspar__MA1562.1	SOX14 (directAnnotation).
PALLD	transfac_pro__M06601	ZNF501 (directAnnotation).
PALLD	transfac_pro__M06111	ZNF254 (directAnnotation).
PALLD	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PALLD	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
PALLD	transfac_pro__M02089	E2F3 (directAnnotation).
PALLD	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PALLD	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PALLD	transfac_pro__M04817	ZBTB33 (directAnnotation).
PALLD	tfdimers__MD00483	ZBTB14 (directAnnotation).
PALLD	cisbp__M07938	E2F1 (directAnnotation).
PALLD	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
PALLD	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
PALLD	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PALLD	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."