Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PAG1

Summary for PAG1

Gene information	Gene symbol	PAG1
	Ensembl ID	ENSG00000076641
	Entrez ID	55824
	Gene name	phosphoprotein membrane anchor with glycosphingolipid microdomains 1
	Synonyms	CBP\|PAG
	Gene type	protein_coding
	UniProtAcc	Q9NWQ8

Top

Dataset with differentially expressed gene: PAG1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.419033	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.390692	1.25e-11
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.365478	2.00e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.377458	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.263282	2.28e-11
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.391723	0.00e+00

Top

Expression of PAG1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to PAG1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating PAG1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PAG1	hsa-miR-3148	99.2223	NM_018440
PAG1	hsa-miR-6867-5p	97.2446	NM_018440
PAG1	hsa-miR-548ar-3p	96.9731	NM_018440
PAG1	hsa-miR-1226-5p	96.4967	NM_018440
PAG1	hsa-miR-627-3p	95.5691	NM_018440
PAG1	hsa-miR-548a-3p	95.0222	NM_018440
PAG1	hsa-miR-548e-3p	94.9894	NM_018440
PAG1	hsa-miR-548az-3p	94.9894	NM_018440
PAG1	hsa-miR-548f-3p	94.9894	NM_018440
PAG1	hsa-miR-548bc	94.9894	NM_018440
PAG1	hsa-miR-6124	94.5277	NM_018440
PAG1	hsa-miR-590-3p	93.2019	NM_018440
PAG1	hsa-miR-3662	92.8367	NM_018440
PAG1	hsa-miR-4666a-5p	92.8102	NM_018440
PAG1	hsa-miR-4698	92.6847	NM_018440
PAG1	hsa-miR-924	92.586	NM_018440
PAG1	hsa-miR-107	91.9712	NM_018440
PAG1	hsa-miR-103a-3p	91.9712	NM_018440
PAG1	hsa-miR-6739-3p	91.4012	NM_018440
PAG1	hsa-miR-548aj-3p	90.1211	NM_018440
PAG1	hsa-miR-548x-3p	90.1211	NM_018440
PAG1	hsa-miR-548ae-3p	89.7134	NM_018440
PAG1	hsa-miR-548ah-3p	89.7134	NM_018440
PAG1	hsa-miR-548am-3p	89.7134	NM_018440
PAG1	hsa-miR-548aq-3p	89.7134	NM_018440
PAG1	hsa-miR-548j-3p	89.7134	NM_018440
PAG1	hsa-miR-493-5p	89.6841	NM_018440
PAG1	hsa-miR-548c-3p	89.1434	NM_018440
PAG1	hsa-miR-15b-5p	88.903	NM_018440
PAG1	hsa-miR-15a-5p	88.903	NM_018440
PAG1	hsa-miR-497-5p	88.903	NM_018440
PAG1	hsa-miR-200b-3p	88.7294	NM_018440
PAG1	hsa-miR-200c-3p	88.7294	NM_018440
PAG1	hsa-miR-429	88.7294	NM_018440
PAG1	hsa-miR-1297	87.9348	NM_018440
PAG1	hsa-miR-3680-3p	87.8325	NM_018440
PAG1	hsa-miR-16-5p	87.792	NM_018440
PAG1	hsa-miR-424-5p	87.792	NM_018440
PAG1	hsa-miR-195-5p	87.792	NM_018440
PAG1	hsa-miR-6838-5p	87.792	NM_018440
PAG1	hsa-miR-625-5p	87.6158	NM_018440
PAG1	hsa-miR-4738-3p	87.4475	NM_018440
PAG1	hsa-miR-6508-5p	87.291	NM_018440
PAG1	hsa-miR-218-5p	87.1641	NM_018440
PAG1	hsa-miR-6773-5p	87.0145	NM_018440
PAG1	hsa-miR-30e-3p	86.9731	NM_018440
PAG1	hsa-miR-30d-3p	86.9731	NM_018440
PAG1	hsa-miR-30a-3p	86.9731	NM_018440
PAG1	hsa-miR-670-3p	86.1328	NM_018440
PAG1	hsa-miR-510-3p	85.7557	NM_018440

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating PAG1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PAG1	hdpi__NRL	NRL (directAnnotation).
PAG1	transfac_pro__M07310	SP5 (directAnnotation).
PAG1	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
PAG1	cisbp__M00968	MTF2 (directAnnotation).
PAG1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
PAG1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
PAG1	tfdimers__MD00483	ZBTB14 (directAnnotation).
PAG1	transfac_pro__M02089	E2F3 (directAnnotation).
PAG1	transfac_pro__M07317	CTBP1 (directAnnotation).
PAG1	transfac_pro__M00716	ZBTB14 (directAnnotation).
PAG1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
PAG1	transfac_pro__M03806	ZBTB7C (directAnnotation).
PAG1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
PAG1	transfac_pro__M04893	TAF1 (directAnnotation).
PAG1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
PAG1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PAG1	transfac_pro__M04916	TAF1 (directAnnotation).
PAG1	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
PAG1	hdpi__RARA	RARA (directAnnotation).
PAG1	hdpi__HTATIP2	HTATIP2 (directAnnotation).
PAG1	jaspar__MA1650.1	ZBTB14 (directAnnotation).
PAG1	hdpi__HIP2	UBE2K (directAnnotation).
PAG1	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
PAG1	hdpi__ZNF304	ZNF304 (directAnnotation).
PAG1	cisbp__M08228	PAX5 (directAnnotation).
PAG1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
PAG1	transfac_pro__M00938	E2F1 (directAnnotation).
PAG1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
PAG1	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
PAG1	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PAG1	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
PAG1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
PAG1	cisbp__M00788	ZFY (inferredBy_Orthology).
PAG1	metacluster_24.3	DIDO1; HINFP; ILF3; ZBTB21; ZFX; ZFX; ZNF283; ZNF37A; ZNF501; ZNF614 (directAnnotation). ZFY; ZFY (inferredBy_Orthology).
PAG1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PAG1	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
PAG1	transfac_pro__M03846	SMAD5 (directAnnotation).
PAG1	metacluster_45.4	E2F2 (directAnnotation).
PAG1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PAG1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
PAG1	metacluster_175.1	ZNF283 (directAnnotation).
PAG1	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
PAG1	hdpi__FEZF2	FEZF2 (directAnnotation).
PAG1	cisbp__M00343	PAX6 (directAnnotation).
PAG1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PAG1	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
PAG1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PAG1	transfac_pro__M12694	ZFP14 (directAnnotation).
PAG1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
PAG1	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).

Page: 1 2 3

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."