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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ODF2L

Summary for ODF2L

Gene information	Gene symbol	ODF2L
	Ensembl ID	ENSG00000122417
	Entrez ID	57489
	Gene name	outer dense fiber of sperm tails 2 like
	Synonyms	KIAA1229
	Gene type	protein_coding
	UniProtAcc	Q9ULJ1

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Dataset with differentially expressed gene: ODF2L

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.30607	2.15e-11
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.276178	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.465332	1.56e-05
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.423459	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.312984	7.46e-42

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Expression of ODF2L in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ODF2L

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ODF2L

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ODF2L	hsa-miR-6729-3p	96.9105	NM_001184766
ODF2L	hsa-miR-4424	96.4188	NM_001007022
ODF2L	hsa-miR-190a-3p	96.4028	NM_001184766
ODF2L	hsa-miR-548ad-3p	94.3851	NM_001184766
ODF2L	hsa-miR-1252-3p	93.8957	NM_001184766
ODF2L	hsa-miR-218-1-3p	93.8278	NM_001007022
ODF2L	hsa-miR-340-5p	93.121	NM_001184766
ODF2L	hsa-miR-577	92.7328	NM_001184766
ODF2L	hsa-miR-656-3p	91.7635	NM_001184766
ODF2L	hsa-miR-3163	89.6288	NM_001184766
ODF2L	hsa-miR-1227-3p	89.35	NM_001007022
ODF2L	hsa-miR-576-5p	89.2338	NM_001007022
ODF2L	hsa-miR-590-3p	89.2048	NM_001184766
ODF2L	hsa-miR-578	88.5295	NM_001007022
ODF2L	hsa-miR-5011-5p	88.4227	NM_001184766
ODF2L	hsa-miR-619-5p	87.3089	NM_001007022
ODF2L	hsa-miR-6506-5p	87.3089	NM_001007022
ODF2L	hsa-miR-3658	86.8922	NM_001184766
ODF2L	hsa-miR-4275	85.9423	NM_001007022
ODF2L	hsa-miR-1257	85.5632	NM_001184766
ODF2L	hsa-miR-26a-2-3p	85.4151	NM_001184766
ODF2L	hsa-miR-26a-1-3p	85.4151	NM_001184766
ODF2L	hsa-miR-335-3p	85.3325	NM_001184766
ODF2L	hsa-miR-2115-3p	85.1657	NM_001007022
ODF2L	hsa-miR-4775	85.0229	NM_001184766
ODF2L	hsa-miR-561-3p	82.8758	NM_001184766
ODF2L	hsa-miR-499b-3p	82.57	NM_001184766
ODF2L	hsa-miR-499a-3p	82.57	NM_001184766
ODF2L	hsa-miR-5699-3p	81.8149	NM_001007022
ODF2L	hsa-miR-4677-5p	81.7124	NM_001007022
ODF2L	hsa-miR-4753-3p	80.0642	NM_001007022

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Motifs and transcription factors (TFs) regulating ODF2L

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ODF2L	tfdimers__MD00557	MZF1 (directAnnotation).
ODF2L	metacluster_136.3	MAX; MXI1; MXI1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX4; RFX4; RFX4; RFX4; RFX5; RFX5; RFX5; SREBF1; ZBTB7B (directAnnotation). RFX1; RFX1; RFX1; RFX1; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX3; RFX3; RFX3; RFX3; RFX3; RFX4; RFX4; RFX4; RFX6; RFX6; RFX6; RFX7; RFX8; RFX8 (inferredBy_Orthology).
ODF2L	transfac_pro__M05540	ZBTB34 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."