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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NGLY1

Summary for NGLY1

Gene information	Gene symbol	NGLY1
	Ensembl ID	ENSG00000151092
	Entrez ID	55768
	Gene name	N-glycanase 1
	Synonyms	FLJ11005\|PNG-1\|PNG1
	Gene type	protein_coding
	UniProtAcc	Q96IV0

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Dataset with differentially expressed gene: NGLY1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.298399	6.29e-13
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.432042	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.356859	4.37e-33

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Expression of NGLY1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NGLY1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NGLY1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NGLY1	hsa-miR-374a-5p	96.3531	NM_001145295
NGLY1	hsa-miR-374b-5p	95.6982	NM_001145295
NGLY1	hsa-miR-23b-3p	95.3913	NM_001145295
NGLY1	hsa-miR-23c	95.3913	NM_001145295
NGLY1	hsa-miR-23a-3p	95.3913	NM_001145295
NGLY1	hsa-miR-621	95.171	NM_018297
NGLY1	hsa-miR-195-3p	90.6565	NM_018297
NGLY1	hsa-miR-16-2-3p	90.6565	NM_018297
NGLY1	hsa-miR-519d-5p	89.8328	NM_001145295
NGLY1	hsa-miR-4760-5p	89.4909	NM_001145295
NGLY1	hsa-miR-7154-5p	89.0296	NM_001145295
NGLY1	hsa-miR-3145-5p	87.7826	NM_018297
NGLY1	hsa-miR-8061	87.2522	NM_001145295
NGLY1	hsa-miR-383-5p	86.9642	NM_018297
NGLY1	hsa-miR-582-5p	84.5006	NM_018297
NGLY1	hsa-miR-3688-3p	81.2736	NM_018297
NGLY1	hsa-miR-548x-5p	80.4593	NM_018297
NGLY1	hsa-miR-548aj-5p	80.4593	NM_018297
NGLY1	hsa-miR-548f-5p	80.4593	NM_018297
NGLY1	hsa-miR-548g-5p	80.4593	NM_018297
NGLY1	hsa-miR-3974	80.0127	NM_001145295

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Motifs and transcription factors (TFs) regulating NGLY1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NGLY1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."